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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
34 Results for "
p65 subunit
" in MedChemExpress (MCE) Product Catalog:
Products (34)
34 Results for "p65 subunit" in MCE Product Catalog:
37
37 Publications Verification
Target:
SC75741 is a broad and efficient NF-κB inhibitor with an IC50 of 200 nM for p65 . SC75741 blocks influenza viruses (IV) replication. SC75741 impairs DNA binding of the NF-κB subunit p65, resulting in reduced expression of cytokines, chemokines, and pro-apoptotic factors. SC75741 subsequently inhibits caspase activation and blocks caspase-mediated nuclear export of viral ribonucleoproteins .
17
17 Cited Publications
Synonyms: (-)-Epicatechol; Epicatechin; epi-Catechin
Category:
Anti-aging Plants Camellia sinensis (L.) O. Ktze. Endogenous metabolite Theaceae Extract Flavonoids Sunscreen Flavanols Phenols Polyphenols Cosmetic Research Disease Research Fields Inflammation/Immunology Cancer
Target:
16
Category:
Xanthones Phenols Polyphenols Anemarrhena asphodeloides Bunge Plants Liliaceae Extract Disease Research Fields Cancer
Target:
6
Category:
Terpenoids Sesquiterpenes Plants Other Families Extract Disease Research Fields Inflammation/Immunology
Target:
4
4 Cited Publications
Cat. No.: HY-P81238
Synonyms: Phospho-NF-KB p65 (Ser536) ;
NF-kB p65 (phospho S536); p-NF-κB p65(Phospho-Ser536); RELA(phospho S536); NF kB p65; NF-kB p65; NFKBp65; NF-κBp65; p65 NF kappaB; p65 NFkB; NFKBp65; RELA; Transcription Factor p65; v rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B cells 3 (p65)); V Rel Avian Reticuloendotheliosis Viral Oncogene Homolog A; v rel reticuloendotheliosis viral oncogene homolog A (avian); v-rel reticuloendotheliosis viral oncogene homolog A; p65NFKB; Avian reticuloendotheliosis viral (v rel) oncogene homolog A; MGC131774; NFKB 3; NFKB3; Nuclear Factor NF Kappa B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B cells 3; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B Cells; TF65_HUMAN. NFκB-p65; NFκB p65; NF κB-p65; NFκBp65;
3
3 Cited Publications
Cat. No.: HY-P1832A
Domaines de recherche:
2
Synonyms: (-)-Epicatechol(Standard); Epicatechin(Standard); epi-Catechin (Standard)
Domaines de recherche:
HD-TAC7 is a selective HDAC3 PROTAC degrader with an IC50 of 1.1 μM. By recruiting the CRBN E3 ligase, HD-TAC7 induces ubiquitin-proteasome degradation and selective downregulation of HDAC3, which in turn increases H3K27 acetylation levels and downregulates the NF-κB subunit p65, exerting anti-inflammatory activity. HD-TAC7 is used in research on COVID-19, SARS-CoV-2 infection, asthma, chronic obstructive pulmonary disease, and colon cancer .
Target:
Cat. No.: HY-P10030
CAS No.: 1801379-22-5
Target:
Domaines de recherche:
Cat. No.: HY-N0811
CAS No.: 139051-27-7
Category:
Anemarrhena asphodeloides Bunge Plants Liliaceae Extract Disease Research Fields Inflammation/Immunology Steroids
Target:
Target:
Domaines de recherche:
(S)-(-)-Anatabine is an NFκB/BACE-1 inhibitor with blood-brain barrier penetration. (S)-(-)-Anatabine inhibits NFκB activation via phosphorylation of its p65 subunit. (S)-(-)-Anatabine inhibits BACE-1 transcription and reduces BACE-1 protein levels. (S)-(-)-Anatabine lowers production of Aβ1-40 and Aβ1-42 by reducing β-cleavage of amyloid precursor protein without affecting α-cleavage. (S)-(-)-Anatabine can be used for the research of Alzheimer's disease .
Cat. No.: HY-P1832
Domaines de recherche:
Cat. No.: HY-N9149
CAS No.: 98570-81-1
Category:
Cardiacglycosides Plants Cryptolepis buchananii Roem. et Schult. Apocynaceae Extract Steroids
Target:
Cat. No.: HY-N0001S
CAS No.: 1217780-28-3
Cat. No.: HY-N0001S2
Synonyms: (-)-Epicatechol-13C3; Epicatechin-13C3; epi-Catechin-13C3
Cat. No.: HY-123461
CAS No.: 1541170-25-5
Target:
Domaines de recherche:
Sul-121 hydrochloride is a novel compound with anti-oxidative capacity that effectively inhibits airway inflammation and hyperresponsiveness (AHR) in experimental models of chronic obstructive pulmonary disease (COPD). Sul-121 hydrochloride prevents lipopolysaccharide-induced airway neutrophilia and AHR in a dose-dependent manner. Sul-121 hydrochloride also demonstrates the ability to reduce oxidative stress markers in human airway smooth muscle cells. Sul-121 hydrochloride inhibits nuclear translocation of the NF-κB subunit, p65, thereby diminishing pro-inflammatory cytokine release.
Cat. No.: HY-P86687
Synonyms: TF65_HUMAN; Transcription factor p65; RELA; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; NFKB3; RELA proto-oncogene, NF-kB subunit; p65; CMCU; NFKB3; AIF3BL3; NF-kB p65/RelA; NFκB-p65; NFκB p65; NF κB-p65; NFκBp65;
Cat. No.: HY-P86720
Synonyms: TF65_HUMAN; Transcription factor p65; RELA; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; NFKB3; RELA proto-oncogene, NF-kB subunit; p65; CMCU; NFKB3; AIF3BL3; NF-kB p65/RelA; NFκB-p65; NFκB p65; NF κB-p65; NFκBp65;
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
