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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
317 Results for "
quinoline-based hydrazone scaffold
" in MedChemExpress (MCE) Product Catalog:
Products (317)
317 Results for "quinoline-based hydrazone scaffold" in MCE Product Catalog:
67
67 Publications Verification
Synonyms: endo-IWR 1; IWR-1-endo
Research Areas:
IWR-1 (IWR-1-endo) is a tankyrase inhibitor targeting Wnt/β-catenin (IC50 = 180 nM). IWR-1 compromises critical steps of the canonical Wnt signaling, namely translocation of β-catenin to the nucleus and subsequent TCF/LEF activation and expression of Wnt/β-catenin downstream targets. IWR-1 promotes β-catenin phosphorylation by promoting stability of Axin-scaffolded destruction complexes. IWR-1 can be studied in research for anti-tumor purposes, and diseases such as osteosarcoma, colorectal cancer and psoriasis .
14
Research Areas:
Fluorescein (Uranine) sodium is widely used as a fluorescent tracer in medicinal and biological applications and tumor infected tissues tracer. Fluorescein (Uranine) sodium is a representative green fluorophore that has been widely used as a scaffold of practically useful green fluorescent probes .
14
7
7 Cited Publications
Synonyms: Tegavivint; BC2059
Tegatrabetan (BC2059) is a β-Catenin antagonist. Tegatrabetan disrupts the binding of β-catenin with the scaffold protein transducin β-like 1 (TBL1) .
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5
5 Cited Publications
Cat. No.: HY-16261B
CAS No.: 480998-12-7
Synonyms: (E/Z)-Aldoxorubicin hydrochloride; Doxorubicin(6-maleimidocaproyl)hydrazone hydrochloride
Target:
Research Areas:
MC-DOXHZN ((E/Z)-Aldoxorubicin; Doxorubicin(6-maleimidocaproyl)hydrazone) hydrochloride is an albumin-binding proagent of Doxorubicin (HY-15142A) (DNA topoisomerase II inhibitor), with acid-sensitive properties. MC-DOXHZN hydrochloride can be used to synthesize ADC .
5
5 Cited Publications
Cat. No.: HY-44076
CAS No.: 85073-19-4
Synonyms: Lithium phenyl-2,4,6-trimethylbenzoylphosphinate
4
Research Areas:
Pyridoxal isonicotinoyl hydrazone is an orally active and lipophilic iron-specific chelator that acts as a non-competitive inhibitor of ferrochelatase (FECH) by binding iron ions. Pyridoxal isonicotinoyl hydrazone disrupts heme biosynthesis, leading to reduced FECH stability and increased protoporphyrin IX (PPIX) accumulation. Pyridoxal isonicotinoyl hydrazone is promising for research of iron-overload diseases (e.g., β-thalassemia) .
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4 Cited Publications
Synonyms: CX05168; CX04328
Target:
Research Areas:
LEDGIN6 (CX05168) is a quinoline-based protein-protein interaction inhibitor of LEDGF/p75 and HIV integrase .
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FAPI-46 is a quinoline-based fibroblast activation protein (FAP)-targeted tracer. Use radioactivity FAPI-46 labeled with 68Ga or 177Lu can be used for tumor imaging in a variety of cancers and has higher tumor uptake rates and longer tumor accumulation .
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3 Cited Publications
Synonyms: TAS6417; CLN-081
Zipalertinib (TAS6417; CLN-081) is a highly effective, orally active and pan-mutation-selective EGFR tyrosine kinase inhibitor with a unique scaffold fitting into the ATP-binding site of the EGFR hinge region, with IC50 values ranging from 1.1-8.0 nM .
1
1 Cited Publications
Cat. No.: HY-W077680
CAS No.: 1126-58-5
Target:
Research Areas:
Girard's P reagent is a reagent used in organic chemistry. Girard's P reagent is used to react with vanillin to form a hydrazone derivative, which is then combined with an ion selective electrode (ISE) to develop a potentiometric method for the determination of vanillin. Girard's P reagent can be used in the development of ion selective electrodes and in the study of organic analysis .
1
Benzoyleneurea possesses anti-bacterial activity. Benzoyleneurea scaffold can be used in the synthesis of novel protein geranylgeranyltransferase-I (PGGTase-I) inhibitors .
1
Category:
Infection Natural Products Distemonanthus benthamianus Baill. Plants Compositae Extract Disease Research Fields
Target:
1
1 Cited Publications
Cat. No.: HY-P72066
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ISCU; Iron-Sulfur Cluster Assembly Enzyme ISCU, Mitochondrial; Prev. NIFUN; Iron-Sulfur Cluster scaffold Homolog (E. Coli); NifU-Like N-Terminal Domain-Containing Protein; IscU Iron-Sulfur Cluster scaffold Homolog; Iron-Sulfur Cluster Assembly Enzyme ISCU
Species:
Human
Source:
Sf9 insect cells
1
Target:
Research Areas:
2,2'-Bipyridine is the unique molecular scaffold of the bioactive natural products. 2,2'-Bipyridine is extensively used as the core structure of many chelating ligands by acting as a bridge in the arrangement of the catalytic center. 2,2'-Bipyridine shows robust redox stability and hyperglycemic activity .
1
1 Cited Publications
Cat. No.: HY-W250312
CAS No.: 24980-41-4
Research Areas:
Polycaprolactone is a biodegradable polyester commonly used in various biomedical and industrial applications. It is a white waxy polymer that can be molded into various shapes and forms. Polycaprolactone has various properties suitable for these applications, including low melting point, high flexibility and slow biodegradation rate. It can be used as a raw material for the production of tissue engineering scaffolds, drug delivery systems, and medical implants. In addition, it is used as a binder in the production of adhesives, coatings and paints.
1
1 Cited Publications
Cat. No.: HY-W089353
CAS No.: 194235-40-0
Cat. No.: HY-W110584
CAS No.: 24249-95-4
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
