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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
101 Results for "
stem cell factor
" in MedChemExpress (MCE) Product Catalog:
Products (101)
101 Results for "stem cell factor" in MCE Product Catalog:
14
14 Publications Verification
Synonyms: Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
Target:
Liposome Endogenous Metabolite ACSL Family Amino acid Transporter Ferroptosis Glutathione Peroxidase
Domaines de recherche:
DOPE (Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine) is an orally active inhibitor of ferroptosis with anti-inflammatory and intestinal barrier maintenance activities. DOPE regulates the expression of ACSL4, SLC7A11 and GPX4 to restore the redox system balance, thereby reducing the levels of lipid peroxides, iron ions and intestinal inflammatory factors (IL-1β and IL-6). DOPE promotes the migration and proliferation of intestinal epithelial cells and increases the level of tight junction proteins; it also destabilizes endosomal membranes, mediates the conjugation of RVG peptides with mesenchymal stem cell-derived exosomes to enhance brain targeting. DOPE can be applied to research related to neonatal necrotizing enterocolitis and Alzheimer's disease .
12
12 Cited Publications
Synonyms: Quinomycin A; NSC-13502
Domaines de recherche:
Echinomycin (Quinomycin A) is potent small-molecule and cell-permeable inhibitor of hypoxia-inducible factor-1 (HIF-1) DNA-binding activity. Echinomycin selectively inhibits the cancer stem cells (CSCs) with an IC50 of 29.4 pM .
7
7 Cited Publications
Cat. No.: HY-18959
CAS No.: 1144044-02-9
CWP232228, a highly potent selective Wnt/β-catenin signaling inhibitor, antagonizes binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 suppresses tumor formation and metastasis without toxicity through the inhibition of the growth of breast and liver cancer stem cells (CSCs) .
6
6 Cited Publications
Cat. No.: HY-P70781
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: KITLG; SLF; Prev. MGF; Familial Progressive Hyperpigmentation 2; SCF; Steel factor; Mast cell Growth factor; C-Kit Ligand; stem cell factor; Kit Ligand; DFNA69; SHEP7; Kitl; DCUA; KL-1; FPHH; FPH2; WS2F; KIT Ligand; SF
Species:
Human
Source:
E. coli
4
4 Cited Publications
Domaines de recherche:
Ki20227 is an orally active and highly selective c-Fms tyrosine kinase (CSF1R) inhibitor with IC50s of 2 nM, 12 nM, 451 and 217 nM for CSF1R, VEGFR2 (vascular endothelial growth factor receptor-2), c-Kit (stem cell factor receptor) and PDGFRβ (platelet-derived growth factor receptor β). Ki20227 suppresses osteoclast differentiation and osteolytic bone destruction .
4
Domaines de recherche:
Tyrphostin AG1296 is a potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR), with an IC50 of 0.8 μM. Tyrphostin AG1296 inhibits signaling of human PDGF α- and β-receptors as well as of the related stem cell factor receptor (c-Kit). Tyrphostin AG1296 is also a potent inhibitor of FLT3, with an IC50 in the micromolar range .
3
3 Cited Publications
PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1 in ovarian cancer. PTC-028 selectively inhibits cancer cells whereas normal cells remain unaffected. PTC-028 downregulates BMI-1, inducing caspase-mediated apoptosis .
3
3 Cited Publications
Cat. No.: HY-P70528
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: KITLG; SLF; Prev. MGF; Familial Progressive Hyperpigmentation 2; SCF; Steel factor; Mast cell Growth factor; C-Kit Ligand; stem cell factor; Kit Ligand; DFNA69; SHEP7; Kitl; DCUA; KL-1; FPHH; FPH2; WS2F; KIT Ligand; SF
Species:
Mouse
Source:
E. coli
3
3 Cited Publications
Cat. No.: HY-P70555
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: KITLG; SLF; Prev. MGF; Familial Progressive Hyperpigmentation 2; SCF; Steel factor; Mast cell Growth factor; C-Kit Ligand; stem cell factor; Kit Ligand; DFNA69; SHEP7; Kitl; DCUA; KL-1; FPHH; FPH2; WS2F; KIT Ligand; SF
Species:
Mouse
Source:
HEK293
2
2 Cited Publications
Cat. No.: HY-P80619
Synonyms: KIT; SCFR; Mast/stem cell growth factor receptor Kit; SCFR; Piebald trait protein; PBT; Proto-oncogene c-Kit; Tyrosine-protein kinase Kit; p145 c-kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD antigen CD117
1
Target:
1
Category:
Alkaloids Lauraceae Extract Phenols Polyphenols Plants Isoquinoline Alkaloids Lindera aggregata (Sims) Kosterm.
Target:
1
Chetomin, an active component of Chaetomium globosum, is a heat shock protein 90/hypoxia-inducible factor 1 alpha (Hsp90/HIF1α) pathway inhibitor. Chetomin is a potent, nontoxic non-small cell lung cancer cancer stem cells (NSCLC CSC)-targeting molecule .
1
1 Cited Publications
Bragsin2 is a potent, selective and noncompetitive nucleotide exchange factor BRAG2 inhibitor, with an IC50 of 3 μM. Bragsin2 binds at the interface between the PH domain of BRAG2 and the lipid bilayer, leads BRAG2 unable to activate lipidated Arf GTPase. Bragsin2 affects breast cancer stem cells .
1
1 Cited Publications
Cat. No.: HY-P70757G
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: KITLG; SLF; Prev. MGF; Familial Progressive Hyperpigmentation 2; SCF; Steel factor; Mast cell Growth factor; C-Kit Ligand; stem cell factor; Kit Ligand; DFNA69; SHEP7; Kitl; DCUA; KL-1; FPHH; FPH2; WS2F; KIT Ligand; SF
Species:
Human
Source:
HEK293
1
Target:
Domaines de recherche:
3,5‑Diiodo‑4‑hydroxybenzoic acid (DIHB) is a plant growth regulator that alleviates the inhibition of plant root elongation under various stress conditions. 3,5-Diiodo-4-hydroxybenzoic acid promotes root elongation under conditions of adequate oxygen supply, absence of stress, and no mechanical impedance, increases the effective cell wall extensibility factor, and promotes root/stem growth in plants in compacted or loose soil; it exhibits lower activity under oxygen stress. 3,5-Diiodo-4-hydroxybenzoic acid can be used in research related to plant growth regulation .
Cat. No.: HY-P99488
CAS No.: 2574591-89-0
Synonyms: JSP-191; AMG-191
Target:
Domaines de recherche:
Cat. No.: HY-N6747
CAS No.: 154589-96-5
Stauprimide is a staurosporine analog that promotes embryonic stem cell (ESC) differentiation. Stauprimide is a non-broad spectrum inhibitor that binds to the MYC transcription factor NME2 and blocks its nuclear localization in ESCs, which results in down-regulation of MYC transcription .
Cat. No.: HY-N6588
CAS No.: 86632-03-3
Synonyms: 3,4,5-triCQA
Cat. No.: HY-P10953
CAS No.: 2868985-56-0
Synonyms: PSP 29-mer, anti-inflammatory peptide
Domaines de recherche:
Fulipiftide (PSP 29-mer) is a short peptide derived from pigment epithelium-derived factor (PEDF). Fulipiftide induces the phosphorylation of ERK2 and STAT3, enriches tendon stem/progenitor cell markers, maintains cell stemness, promotes colony formation and niche expansion, and drives cell infiltration into injured tendons. Fulipiftide promotes the oriented formation of collagen fibers, regulates collagen deposition, and reduces inflammatory cell infiltration and neovascularization. Fulipiftide can be used in studies related to acute tendon injury .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
