2. Apoptosis
  3. TNF Receptor
  4. Tabalumab

Tabalumab  (Synonyms: LY2127399)

Cat. No.: HY-P99220 Purity: 98.11%
COA

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Tabalumab (LY2127399) is a human anti-BAFF (B-cell activating factor) monoclonal antibody (IgG4 type) with neutralising activity against membrane bound and soluble BAFF. Tabalumab can be used in studies of autoimmune diseases such as rheumatoid arthritis, renal failure and systemic lupus erythematosus.

For research use only. We do not sell to patients.

Tabalumab Chemical Structure

Tabalumab Chemical Structure

CAS No. : 1143503-67-6

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Based on 1 publication(s) in Google Scholar

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Description

Tabalumab (LY2127399) is a human anti-BAFF (B-cell activating factor) monoclonal antibody (IgG4 type) with neutralising activity against membrane bound and soluble BAFF. Tabalumab can be used in studies of autoimmune diseases such as rheumatoid arthritis, renal failure and systemic lupus erythematosus[1].

IC50 & Target

BAFF[1].
In Vitro

Tabalumab (1-100 ng/mL; 44 h) neutralizes soluble and membrane-bound BaFF both in T1165.17 cells and (1 µg/mL; 3 days) CD19+ B-cells[1].
Tabalumab (50 µg/mL; 15 min) inhibits BaFF binding to BR3, TacI, and BcMa in HEK293 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tabalumab Related Antibodies

Cell Viability Assay[1]

Cell Line: T1165.17 cells
Concentration: 1-100 ng/mL
Incubation Time: 44 h
Result: Neutralizeed tabalumab neutralization of soluble human, cynomolgus monkey, or rabbit BAFF with IC50 values of 104, 143, and 176 pM in T1165.17 cells, respectively.

Cell Viability Assay[1]

Cell Line: CD19+ B-cells
Concentration: 1 µg/mL
Incubation Time: 3 days
Result: Demonstrated the ability to neutralize the membrane-bound form of BAFF compared with the soluble form of BAFF.

Cell Viability Assay[1]

Cell Line: HEK293 cells (transfected with either BR3, TACI, or BCMA)
Concentration: 50 µg/mL
Incubation Time: 15 min (pre-treat)
Result: Prevented the binding of BAFF to BR3, TACI, or BCMA on the cell surface.
In Vivo

Tabalumab (500 µg/rat; s.c.; single) leads to decreased B-cells and a reduction in non-canonical nF-κB signaling[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Human BAFF Tg mice[1].
Dosage: 500 µg/rat
Administration: Subcutaneous injection, single.
Result: Significantly decreased the splenic B-cell count between day 4 and 8.
Decreased levels of p52, which returned to near the BAFF Tg level at Day 23.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Tabalumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 98.11%

COA (231 KB)

Handling Instructions (2659 KB)
References
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Tabalumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tabalumab1143503-67-6LY2127399LY 2127399LY-2127399TNF ReceptorTumor Necrosis Factor ReceptorTNFRrheumatoid arthritissystemic lupus erythematosusIgG4autoimmune diseasesT1165.17CD19+ B-cellsHEK293Inhibitorinhibitorinhibit

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