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Cat. No.: HY-172898

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TRPA1-IN-4

TRPA1-IN-4 (12) is a TRPA1 inhibitor, with an IC₅₀ of 45 nM. TRPA1-IN-4 (12) can be used in the pain research.

For research use only. We do not sell to patients.

Formula: C₂₂H₁₉F₄N₃O₄S
Molecular Weight:497.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

TRPA1-IN-4 Chemical Structure

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Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

TRPA1-IN-4 (12) is a TRPA1 inhibitor, with an IC₅₀ of 45 nM. TRPA1-IN-4 (12) can be used in the pain research^[1].

All TRP Channel Isoforms :

In Vivo

TRPA1-IN-4 (12, C57BL/6J mice, 50 nmoL/10 μL, i.pl. (intraplantar)) shows strong nanomolar activity and reduces pain in mouse models using AITC and Formalin^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 497.46
Formula C₂₂H₁₉F₄N₃O₄S
SMILES

O=C([C@H]1N(S(=O)(C2=CC=C(F)C=C2)=O)CCC1)NCC3=NOC(C4=CC=C(C(F)(F)F)C=C4)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Valentina Albanese, et al. Identification of isoxazole-based TRPA1 inhibitors with analgesic effects in vivo. Eur J Med Chem. 2025 May 9:294:117732. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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