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DAPT

(Synonyms: GSI-IX)
169 Cited Publications
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Based on 169 publication(s) in Google Scholar

DAPT (GSI-IX) is a potent and orally active γ-secretase inhibitor with IC50s of 115 nM and 200 nM for total amyloid-β (Aβ) and Aβ42, respectively. DAPT inhibits the activation of Notch 1 signaling and induces cell differentiation. DAPT also induces autophagy and apoptosis. DAPT has neuroprotection activity and has the potential for autoimmune and lymphoproliferative diseases, degenerative disease and cancers treatment.

For research use only. We do not sell to patients.

  • Purity: 99.97%
  • CAS No.: 208255-80-5
  • Formula: C23H26F2N2O4
  • Molecular Weight:432.46
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • DAPT Chemical Structure
    DAPT Chemical Structure
  • Experimental Validation Results for DAPT
  • Experimental Validation Results for DAPT
  • Experimental Validation Results for DAPT
  • Experimental Validation Results for DAPT
  • Experimental Validation Results for DAPT
  • Experimental Validation Results for DAPT
  • Experimental Validation Results for DAPT
  • Experimental Validation Results for DAPT
  • Experimental Validation Results for DAPT
  • Experimental Validation Results for DAPT
  • Experimental Validation Results for DAPT
  • Experimental Validation Results for DAPT
  • Experimental Validation Results for DAPT
  • Experimental Validation Results for DAPT
CAS No.: 208255-80-5
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[email protected] [email protected]
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  • DAPT Chemical Structure
    DAPT Chemical Structure
    1/16
  • 1/16

    DAPT purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Oct 20;14(1):6669. [Abstract]

    Customer Validation
     Dose response curve assessed as percentage of cell viability of two ATRT cell lines, upon treatment with DAPT.

  • 1/16

    DAPT purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Oct 20;14(1):6669. [Abstract]

    Customer Validation
     Western blot analyses for Notch intracellular domain NICD in CHLA-02 and IC-032 cell lines treated with DAPT (10 µM; 7 days) NOTCH inhibitor or DMSO as a control.

  • 1/16

    DAPT purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2022 Nov:246:114183. [Abstract]

    Customer Validation
     DAPT treatment enhances the protein expression of Bax and decreases the expression of Bcl2. And the expression of cleaved-caspase3 is upregulated after DAPT treatment (10 μM; for 24 h).

  • 1/16

    DAPT purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2022 Nov:246:114183. [Abstract]

    Customer Validation
     Detection of cell viability after treatment with different concentrations of DAPT (5 μM, 10 μM, 15 μM, 20 μM; for 24 h).

  • 1/16

    DAPT purchased from MedChemExpress. Usage Cited in: Neural Regen Res. 2019 Mar;14(3):452-461. [Abstract]

    Customer Validation
     Western blot assay for Hes1 (left) and Hes5 (right) protein expression in the right prefrontal cortex of cerebral I/R mice following DAPT treatment.

  • 1/16

    DAPT purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2018 Nov:107:1370-1376. [Abstract]

    Customer Validation
     ECa109 and EC9706 cells are treated with concentrations of GSI-DAPT (0, 10 and 20 μM) for 48 h. The expressions of Notch3, DTX1 and Hes1 are investigated by Western blotting.

  • 1/16

    DAPT purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2018 Nov:107:1370-1376. [Abstract]

    Customer Validation
     ECa109 and EC9706 cells are treated with concentrations of GSI-DAPT (0, 10 and 20 μM) for 48 h. The expressions of LSD1 and H3K4me2 are investigated by Western blotting.

  • 1/16

    DAPT purchased from MedChemExpress. Usage Cited in: Drug Des Devel Ther. 2018 Nov 8:12:3847-3854. [Abstract]

    Customer Validation
     Western anslysis of protein analysis of NOX2, NICD, Hes1, Hes5 in the treatment of TBI, TBI+vehicle, TBI+DAPT and TBI+DPI, respectively.

  • 1/16

    DAPT purchased from MedChemExpress. Usage Cited in: Int J Cancer. 2018 Aug 1;143(3):645-656. [Abstract]

    Customer Validation
     Evaluation of expression change of Notch downstream under the androgen-deprived condition with or without the treatment of DAPT by western blot assay.

  • 1/16

    DAPT purchased from MedChemExpress. Usage Cited in: J Cell Physiol. 2018 Mar;233(3):2225-2237. [Abstract]

    Customer Validation
     DAPTprevents Nicd splitting from Notch1 and has been recognized as a Notch1 pathway inhibitor. Treatment with DAPT also inhibits the expression of Col IV and FN, resembling the effect of Notch1 siRNA.

  • 1/16

    DAPT purchased from MedChemExpress. Usage Cited in: J Cell Biochem. 2019 Feb;120(2):1903-1915. [Abstract]

    Customer Validation
     The distribution of aggrecan is increased in the DAPT group.

  • 1/16

    DAPT purchased from MedChemExpress. Usage Cited in: PLoS One. 2018 Feb 15;13(2):e0193037. [Abstract]

    Customer Validation
     After DAPT treatment, the protein levels of Notch, Hes1 and Hes5 are downregulated in severe injury group. After DAPT treatment, the protein levels of Bcl-2 are upregulated while those of Bax, caspase-3 and caspase-9 are downregulated.

  • 1/16

    DAPT purchased from MedChemExpress. Usage Cited in: World J Gastroenterol. 2017 Apr 7;23(13):2330-2336. [Abstract]

    Customer Validation
     Notch γ-secretase inhibitor attenuates notch and transforming growth factor-β signaling pathways in peripheral blood mononuclear cells of liver fibrosis rats. Western blot analysis of protein expression of Notch1, Hes1, Hes5, TGF-β and Smad3 and quantification in PBMCs (2 × 106) from rats treated with DAPT or DMSO for 24 h.

  • 1/16

    DAPT purchased from MedChemExpress. Usage Cited in: Yale University. 2016 Jan.

    Customer Validation
     Treatment with DAPT does not markedly alter expression of p27Kip1 in bulk or CD133- cells, but dramatically enhances its expression in CD133+ cells.

  • DAPT