α-Ionone
Based on 1 Customer Validation
α-Ionone (alpha-Ionone) is an activator of the olfactory receptor OR10A6. α-Ionone induces apoptosis by activating OR10A6 and increasing the phosphorylation of the LATS-YAP-TAZ signaling axis in the Hippo pathway. α-Ionone can inhibit tumor formation both in vivo and in vitro.
For research use only. We do not sell to patients.
- Purity: 94.30%
- CAS No.: 127-41-3
- Formula: C13H20O
- Molecular Weight:192.30
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| LNCaP | IC50 |
151 μM
Compound: beta-lonone
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Cytotoxicity against androgen-dependent human LNCAP cells with T877A AR mutant after 72 hrs by MTT assay
Cytotoxicity against androgen-dependent human LNCAP cells with T877A AR mutant after 72 hrs by MTT assay
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[PMID: 19138519] |
α-Ionone (0-1000 μM) results in a dose-dependent increase in the level of cAMP in A431 cells with an EC50 = 152.4 μM[1].
α-Ionone (100-250 μM) inhibits the proliferation of HaCaT cells[1].
α-Ionone (0-200 μM, 48 h) significantly inhibits the migration of A431 cells dose-dependently[1].
α-Ionone (100-200 μM) increases the phosphorylation of LATS, YAP, and TAZ in A431 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A431 cells
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Concentration:100, 200 μM
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Incubation Time:48 h
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Result:Increased the levels of cleaved caspase-3 and the preapoptotic protein BAX.
Reduced antiapoptotic protein BCL-2.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male BALB/c nude mice (6 w, 18-22 g) with A431 cell xenograft[1]
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Dosage:200 mg/kg
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Administration:Intraperitoneal injection (i.p.)
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Result:Dramatically inhibited tumor growth.
Did not lead to significant changes in body weight.
Increased the phosphorylation of the Hippo pathway proteins LATS, YAP, and TAZ in A431 tumor tissues in mice.
Chemical Information
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CAS No. 127-41-3
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Appearance Liquid (Density: 0.92 g/cm3)
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Molecular Weight 192.30
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Formula C13H20O
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Color Colorless to light yellow
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SMILES
CC1=CCCC(C)(C)C1/C=C/C(C)=O
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Synonyms
alpha-Ionone
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 200 mg/mL (1040.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (26.00 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (26.00 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (418 KB)
- English - EN (418 KB)
- Français - FR (418 KB)
- Deutsch - DE (418 KB)
- Norwegian - NO (418 KB)
- Español - ES (418 KB)
- Swedish - SV (418 KB)
- Italian - IT (418 KB)
- Portuguese - PT (418 KB)
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Handling Instructions (2659 KB)
References
[1]. Yoon YE, et al. A Food Odorant, α-Ionone, Inhibits Skin Cancer Tumorigenesis by Activation of OR10A6. Mol Nutr Food Res. 2024 Aug;68(15):e2400085. [Content Brief]
[2]. Ozgen U, et al. A new sulfated alpha-ionone glycoside from Sonchus erzincanicus Matthews. Molecules. 2010 Apr 12;15(4):2593-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.2002 mL | 26.0010 mL | 52.0021 mL | 130.0052 mL |
| 5 mM | 1.0400 mL | 5.2002 mL | 10.4004 mL | 26.0010 mL | |
| 10 mM | 0.5200 mL | 2.6001 mL | 5.2002 mL | 13.0005 mL | |
| 15 mM | 0.3467 mL | 1.7334 mL | 3.4668 mL | 8.6670 mL | |
| 20 mM | 0.2600 mL | 1.3001 mL | 2.6001 mL | 6.5003 mL | |
| 25 mM | 0.2080 mL | 1.0400 mL | 2.0801 mL | 5.2002 mL | |
| 30 mM | 0.1733 mL | 0.8667 mL | 1.7334 mL | 4.3335 mL | |
| 40 mM | 0.1300 mL | 0.6500 mL | 1.3001 mL | 3.2501 mL | |
| 50 mM | 0.1040 mL | 0.5200 mL | 1.0400 mL | 2.6001 mL | |
| 60 mM | 0.0867 mL | 0.4334 mL | 0.8667 mL | 2.1668 mL | |
| 80 mM | 0.0650 mL | 0.3250 mL | 0.6500 mL | 1.6251 mL | |
| 100 mM | 0.0520 mL | 0.2600 mL | 0.5200 mL | 1.3001 mL |
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