β-Amyrone
Based on 1 publication(s) in Google Scholar
β-Amyrone (β-Amyron) is a triterpene compound which has anti-inflammatory activity through inhibiting the expression of COX-2. β-Amyrone has antifungal activity , as well as antiviral activity against Chikungunya virus. β-Amyrone also inhibits α-glucosidase and acetylcholinesterase (AChE) activity. β-Amyrone can be used in the research of disease like inflammation, infection, and obesity.
For research use only. We do not sell to patients.
- Purity: 99.87%
- CAS No.: 638-97-1
- Formula: C30H48O
- Molecular Weight:424.70
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) β-Amyrone
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Biological Activity
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COX-2 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B16 | ED50 |
>50 μM
Compound: 15, beta-amyrenone
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Induction of melanogenesis in mouse B16 2F2 cells assessed as intracellular melanin content after 3 days
Induction of melanogenesis in mouse B16 2F2 cells assessed as intracellular melanin content after 3 days
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[PMID: 12027734] |
| B16 | IC50 |
38.7 μM
Compound: 15, beta-amyrenone
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Growth inhibition of mouse B16 2F2 cells after 3 days
Growth inhibition of mouse B16 2F2 cells after 3 days
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[PMID: 12027734] |
| BV-2 | IC50 |
>50 μM
Compound: 5
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Inhibition of iNOS-mediated NO production in LPS-induced mouse BV2 cells
Inhibition of iNOS-mediated NO production in LPS-induced mouse BV2 cells
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[PMID: 18926710] |
β-Amyrone (1.25-10 μg/mL, 24 h) inhibits on NO∙ production in LPS-stimulated J774 cells, with an IC50 value of 4.61 μg/mL, and has no obvious effect on cell viability[1].
β-Amyrone (10 μg/mL, 24 h) inhibits IL-6, IL-10 levels, and COX-2 expression in LPS-stimulated J774 cells[1].
β-Amyrone (0-235 μM, 7days) has antiviral activity in Vero cells against Chikungunya virus (CHIKV), with EC50 value of 86 uM[2].
β-Amyrone inhibits α-glucosidase, acetylcholinesterase (AChE) and fungal activity with IC50 values of 25 μM, 23 μM and 8 μg/mL, respectively[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LPS (1 μg/mL)-stimulated J774 cells
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Concentration:2.5, 5, 10 μg/mL
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Incubation Time:24 h
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Result:Inhibited COX-2 expression in a concentration-dependent manner (approximately 90% reduction at 5 or 10 μg/ mL).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Ear phenol-induced edema in Balb C mice[1]
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Dosage:0.1, 0.3, 0.6 mg/kg, a single dose
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Administration:Local administration (20 𝜇L solution) on ear
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Result:Inhibited ear edema formation in a dose-related manner (47% inhibition at the dose of 0.6mg/kg).
Chemical Information
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CAS No. 638-97-1
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Appearance Solid
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Molecular Weight 424.70
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Formula C30H48O
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Color White to off-white
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SMILES
C[C@]12[C@]3(C([C@@]4([H])[C@@](CC3)(CCC(C)(C4)C)C)=CC[C@]1([H])[C@@]5([C@@](C(C)(C(CC5)=O)C)([H])CC2)C)C
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Synonyms
β-Amyron
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
Ethanol : 12.5 mg/mL (29.43 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% EtOH 90% Corn Oil
Solubility: ≥ 1.25 mg/mL (2.94 mM); Clear solution
This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (280 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Patrícia D O de Almeida, et al. Anti-Inflammatory Activity of Triterpenes Isolated from Protium paniculatum Oil-Resins. Evid Based Complement Alternat Med. 2015;2015:293768. [Content Brief]
[2]. Mélanie Bourjot, et al. Chemical constituents of Anacolosa pervilleana and their antiviral activities. Fitoterapia. 2012 Sep;83(6):1076-80. [Content Brief]
[3]. Ki-Kwang Oh, et al. Elucidating Drug-Like Compounds and Potential Mechanisms of Corn Silk ( Stigma Maydis) against Obesity: A Network Pharmacology Study. Curr Issues Mol Biol. 2021 Nov 6;43(3):1906-1936. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 2.3546 mL | 11.7730 mL | 23.5460 mL | 58.8651 mL |
| 5 mM | 0.4709 mL | 2.3546 mL | 4.7092 mL | 11.7730 mL | |
| 10 mM | 0.2355 mL | 1.1773 mL | 2.3546 mL | 5.8865 mL | |
| 15 mM | 0.1570 mL | 0.7849 mL | 1.5697 mL | 3.9243 mL | |
| 20 mM | 0.1177 mL | 0.5887 mL | 1.1773 mL | 2.9433 mL | |
| 25 mM | 0.0942 mL | 0.4709 mL | 0.9418 mL | 2.3546 mL |
β-Amyrone Related Classifications
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