2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. Carnitine Palmitoyltransferase (CPT) PPAR Apolipoprotein
  4. 9(S)-HOTrE

9(S)-HOTrE is a PPARα activator and an inducer of apolipoprotein A-I (apoA-I) mRNA expression. 9(S)-HOTrE upregulates the expression of PPARα target gene CPT1α. 9(S)-HOTrE can be used in the research of cardiovascular diseases.

For research use only. We do not sell to patients.

9(S)-HOTrE

9(S)-HOTrE Chemical Structure

CAS No. : 89886-42-0

Size Price Stock Quantity
Solvent
100 μg (3.40 mM * 100 μL in Ethanol) In-stock

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

9(S)-HOTrE Related Antibodies

Top Publications Citing Use of Products

View All PPAR Isoform Specific Products:

View All Isoforms
PPARα PPARβ/δ PPARγ PPAR PPARδ

View All Apolipoprotein Isoform Specific Products:

View All Isoforms
apoE apoB apoA1 apoA2 apoA4 apoC1 apoC2 apoC3

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

9(S)-HOTrE is a PPARα activator and an inducer of apolipoprotein A-I (apoA-I) mRNA expression. 9(S)-HOTrE upregulates the expression of PPARα target gene CPT1α. 9(S)-HOTrE can be used in the research of cardiovascular diseases[1].

IC50 & Target[1]

CPT-1A

 

PPARα

 

In Vitro

9(S)-HOTrE (9 μg/mL; 16 h) potently activates the transcriptional activity of PPARα in HEK293 cells, and its activity at the concentration of 9 μg/mL is 11.6 times higher than that of the control group[1].
9(S)-HOTrE (10 μg/mL) activates PPARα in HepG2 cells, and at the concentration of 10 μg/mL, it increases the expression level of CPT1α mRNA by 8.0-fold compared with the control group[1].
9(S)-HOTrE (0.01-10 μg/mL) regulates the expression level of apoA-I mRNA in HepG2 cells[1].
9(S)-HOTrE (0.01-0.1 μg/mL) upregulates KEAP1 mRNA expression in HepG2 cells at concentrations that stimulate apoA-I transcription (0.01 μg/mL and 0.05 μg/mL), while it downregulates KEAP1 mRNA expression at the concentration of 0.1 μg/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

9(S)-HOTrE Related Antibodies

RT-PCR[1]

Cell Line: HepG2 cells
Concentration: 0.01, 0.05, 0.1, 0.5, 1, 3, 5, 7, 8.3, 10 μg/mL
Incubation Time: /
Result: Increased apoA-I mRNA expression by 35% in HepG2 cells at an optimal concentration of 0.05 μg/mL, while reduced apoA-I mRNA expression at higher concentrations (≥3 μg/mL).
Molecular Weight

294.43

Formula

C18H30O3
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CC/C=C\C/C=C\C=C\[C@@H](O)CCCCCCCC(O)=O
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Purity & Documentation

Purity: 99.9%

SDS (393 KB)

COA (238 KB)

Handling Instructions (2659 KB)
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

9(S)-HOTrE Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

9(S)-HOTrE89886-42-0Carnitine Palmitoyltransferase (CPT)PPARApolipoproteinCarnitine O-palmitoyltransferasePeroxisome proliferator-activated receptorsPPARαapoA-I mRNAcardiovascular diseaseHEK293 cellsKEAP1 mRNACPT1αHepG2 cellsliver cellsbromodomain-containing protein 4Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
9(S)-HOTrE
Cat. No.:
HY-113510
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Korean - KR (393 KB) Portuguese - PT (393 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.