1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. ATX inhibitor 1

ATX inhibitor 1 

Cat. No.: HY-111410 Purity: 99.75%
Handling Instructions

ATX inhibitor 1 is a potent ATX (IC50=1.23 nM, FS-3 and 2.18 nM, bis-pNPP) inhibitor.

For research use only. We do not sell to patients.

ATX inhibitor 1 Chemical Structure

ATX inhibitor 1 Chemical Structure

CAS No. : 2225892-70-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
5 mg USD 240 In-stock
Estimated Time of Arrival: December 31
10 mg USD 380 In-stock
Estimated Time of Arrival: December 31
50 mg USD 980 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1400 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

ATX inhibitor 1 is a potent ATX (IC50=1.23 nM, FS-3 and 2.18 nM, bis-pNPP) inhibitor.

IC50 & Target

IC50: 1.23 nM (FS-3) and 2.18 nM (bis-pNPP)[1]

Molecular Weight

501.30

Formula

C₂₁H₂₃Cl₂N₂O₆P

CAS No.

2225892-70-4

SMILES

O=P(O)(O)CC1=CC=C(NC(C2CCN(C(OCC3=CC(Cl)=CC(Cl)=C3)=O)CC2)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (498.70 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9948 mL 9.9741 mL 19.9481 mL
5 mM 0.3990 mL 1.9948 mL 3.9896 mL
10 mM 0.1995 mL 0.9974 mL 1.9948 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.15 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.15 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.15 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

ATX inhibitor 1ATX inhibitor1ATX inhibitor-1Phosphodiesterase (PDE)Inhibitorinhibitorinhibit

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Product Name:
ATX inhibitor 1
Cat. No.:
HY-111410
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