Azasetron hydrochloride
Based on 2 publication(s) in Google Scholar
Azasetron (Y-25130) hydrochloride, a benzamide derivative, is a potent and selective 5-HT3 receptor antagonist. Azasetron is used in the study for Chemotherapy-induced nausea and vomiting (CINV).
For research use only. We do not sell to patients.
- Purity: 99.76%
- CAS No.: 123040-16-4
- Formula: C17H21Cl2N3O3
- Molecular Weight:386.27
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Azasetron hydrochloride
MoreAll 5-HT Receptor Isoforms
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Biological Activity
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5-HT3 Receptor 0.33 nM (IC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Four male Bama miniature pigs weighing 9-11 kg (15-16 weeks old)[2].
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Dosage:0.5 mg/kg.
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Administration:I.V. administration via the abdominal vein.
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Result:The mean plasma concentration dropped to minimum at 36 h. Cmax = 44.88 ± 7.16 ng/mL) was achieved at the time point of 66.00 ± 22.98 h (Tmax).
Chemical Information
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CAS No. 123040-16-4
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Appearance Solid
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Molecular Weight 386.27
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Formula C17H21Cl2N3O3
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Color White to off-white
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SMILES
O=C(C1=C(OCC(N2C)=O)C2=CC(Cl)=C1)NC3CN4CCC3CC4.[H]Cl
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Synonyms
Y-25130 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Protein Cell
Identification of serotonin 2A receptor as a novel HCV entry factor by a chemical biology strategy. [Abstract]2019 Mar;10(3):178-195. PMID: 29542010 -
Solvent & Solubility
H2O : 20 mg/mL (51.78 mM; Need ultrasonic)
DMSO : 2.22 mg/mL (5.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (129.44 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Sato, N., et al., Antagonistic activity of Y-25130 on 5-HT3 receptors. Jpn J Pharmacol, 1992. 59(4): p. 443-8. [Content Brief]
[2]. Haga, K., et al., The effects of orally administered Y-25130, a selective serotonin3-receptor antagonist, on chemotherapeutic agent-induced emesis. Jpn J Pharmacol, 1993. 63(3): p. 377-83. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.5889 mL | 12.9443 mL | 25.8886 mL | 64.7216 mL |
| 5 mM | 0.5178 mL | 2.5889 mL | 5.1777 mL | 12.9443 mL | |
| H2O | 10 mM | 0.2589 mL | 1.2944 mL | 2.5889 mL | 6.4722 mL |
| 15 mM | 0.1726 mL | 0.8630 mL | 1.7259 mL | 4.3148 mL | |
| 20 mM | 0.1294 mL | 0.6472 mL | 1.2944 mL | 3.2361 mL | |
| 25 mM | 0.1036 mL | 0.5178 mL | 1.0355 mL | 2.5889 mL | |
| 30 mM | 0.0863 mL | 0.4315 mL | 0.8630 mL | 2.1574 mL | |
| 40 mM | 0.0647 mL | 0.3236 mL | 0.6472 mL | 1.6180 mL | |
| 50 mM | 0.0518 mL | 0.2589 mL | 0.5178 mL | 1.2944 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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