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    Metabolic Enzyme/Protease
  2. Estrogen Receptor/ERR
    Endogenous Metabolite
  3. Ethynyl Estradiol

Ethynyl Estradiol (Synonyms: 17α-Ethynylestradiol; Ethynylestradiol)

Cat. No.: HY-B0216 Purity: 99.87%
Handling Instructions

Ethynyl estradiol is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills.

For research use only. We do not sell to patients.

Ethynyl Estradiol Chemical Structure

Ethynyl Estradiol Chemical Structure

CAS No. : 57-63-6

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
500 mg USD 96 In-stock
Estimated Time of Arrival: December 31
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Description

Ethynyl estradiol is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills. Target: Estrogen Receptor Ethinyl estradiol (EE), also sometimes written as ethinylestradiol, ethynyl estradiol, or ethinyl estradiol, is a derivative of 17β-estradiol (E2), the major endogenous estrogen in humans. EE is an orally bioactive estrogen used in many formulations of combined oral contraceptive pills. It is one of the most commonly used medications for this purpose. Transdermal ethinyl estradiol carries a greater risk of clot formation and venous thromboembolism than 17 beta estradiol, which some have theorized to be related to different amounts of hepatic metabolism after absorption. The same contraindications and precautions apply for EE as with other estrogen medications. Estinyl was a preparation of EE alone that was used for the management of menopausal symptoms and female hypogonadism. EE is released into the environment as a xenoestrogen from the urine and feces of people who take it as a medication. The major concern with unopposed estrogen is of endometrial cancer. As such, the medication is generally prescribed with progesterone in the setting of birth control. The first orally active semisynthetic steroidal estrogen, EE (17α-ethynylestradiol), the 17α-ethynyl analog of E2, was synthesized in 1938 by Hans Herloff Inhoffen and Walter Hohlweg at Schering AG in Berlin.

IC50 & Target

Human Endogenous Metabolite

 

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (101.21 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3738 mL 16.8691 mL 33.7382 mL
5 mM 0.6748 mL 3.3738 mL 6.7476 mL
10 mM 0.3374 mL 1.6869 mL 3.3738 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

296.40

Formula

C₂₀H₂₄O₂

CAS No.

57-63-6

SMILES

OC1=CC=C2C(CC[[email protected]]3([H])[[email protected]]2([H])CC[[email protected]@]4(C)[[email protected]@]3([H])CC[[email protected]]4(C#C)O)=C1

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.87%

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Product Name:
Ethynyl Estradiol
Cat. No.:
HY-B0216
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Ethynyl Estradiol

Cat. No.: HY-B0216