Infection

Phosphoglycolic acid is a metabolite and a bacterial cytoplasmic component. Phosphoglycolic acid acts as a by-product generated during the preparation of phosphoglycolohydroxamic acid via hydrolysis of ethyl phosphoglycolate. Phosphoglycolic acid also functions as an active component of postbiotics.

Sisomicin (sulfate) (Standard) is the analytical standard of Sisomicin (sulfate). This product is intended for research and analytical applications. Sisomicin sulfate is a broad-spectrum aminoglycoside antibiotic produced by Micromonospora inyoensis. Sisomicin sulfate is highly active against Gram-positive bacteria[4].

Deoxytopsentin (compound 5) is a marine bisindole alkaloid and also a MRSA pyruvate kinase inhibitor. Deoxytopsentin exists in sponges. Deoxytopsentin exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus strains in vitro.

Homo-BacPROTAC7 TFA is a PROTAC protein degrader targeting ClpC1/ClpC2 with a K_d of 0.5-2.5 nM for both targets. Homo-BacPROTAC7 (TFA) acts as a bactericidal agent, induces killing of pathogenic mycobacteria, retains activity against dormant-like mycobacterial cells with reduced intracellular ATP levels, and shows elevated antibiotic potency relative to its parent monomer. Homo-BacPROTAC7 (TFA) can be used for the research of tuberculosis.

Nifursol is an orally active veterinary antibiotic. Nifursol inhibits Histomonas meleagridis. Nifursol prevents histomoniasis in turkeys. Nifursol is widely used in studies of Escherichia coli gastroenteritis in Salmonella-infected poultry and aquatic animals.

Daclatasvir (dihydrochloride) (Standard) is the analytical standard of Daclatasvir (dihydrochloride). This product is intended for research and analytical applications. Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) is a potent and orally active HCV NS5A protein inhibitor with EC₅₀s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir dihydrochloride is also an organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC₅₀s of 1.5 µM and 3.27 µM, respectively.

Hexamidine diisethionate is an antimicrobial agent targeting Acanthamoeba protozoa. Hexamidine diisethionate is promising for research of ocular infectious diseases such as Acanthamoeba keratitis.

6-Methylpurine riboside (6-MPR) is an antibiotic extracted from the culture medium of the basidiomycete fungi Collybia dryophilia and Collybia maculata. 6-Methylpurine riboside possesses antifungal, antiviral, and antitumor activities.

Dipropyl phthalate-d₄ (NSC 15314-d₄) is the deuterated-labeled Dipropyl phthalate (HY-B1944). Dipropyl phthalate is an immunomodulator. Dipropyl phthalate alters the activities of acid phosphatase, phenoloxidase and superoxide dismutase, increases the activity of β-glucuronidase in a dose-dependent manner, and elevates the mRNA level of hemocyanin in shrimp. Dipropyl phthalate activates the FoxO signaling pathway, interferes with cell proliferation and apoptosis, downregulates chondrocyte-related genes, and induces craniofacial cartilage developmental malformations in zebrafish embryos. Dipropyl phthalate can be used in studies related to Aeromonas veronii infection and micrognathia syndrome.

Mansonone E (Compound 5) is a pesticide. Mansonone E can be isolated from heartwood of Mansonia gagei. Mansonone E has significant antifungal activity against Cladosporium cucumerinum, Candida albicans and Phytophthora parasitica. Mansonone E has potent antibacterial activity with MIC₅₀s of both 7.8 μg/mL for Xanthomonas oryzae pv. oryzae and X. oryzae pv. Oryzicola. Mansonone E also has antifeedant and herbicidal activities.

Ethyl salvianolate A (Ethyl salvionolate A) is an anti-HIV-1 compound that can be extracted from the roots of Salvia yunnanensis. Ethyl salvianolate A inhibits P24 antigen in HIV-1 infected MT-4 cell cultures (EC₅₀: 1.44 μg/mL). Ethyl salvianolate A inhibits HIV-1 replicative enzymes, with IC₅₀s of 56.38 μM (Reverse transcriptase), 12.03 μM (Protease), 14.54 μM (Integrase), respectively.

N-Benzylethylenediamine is a polyamine compound. N-Benzylethylenediamine can effectively release Ca²⁺ from the outer membrane of Escherichia coli (ED₅₀: 200-500 μM), but cannot induce TPP⁺ uptake.

Metaldehyde is an orally active molluscicide. Metaldehyde acts as a feeding inhibitor. Metaldehyde disrupts the feeding cycle, impairs righting ability, delays fecal excretion, induces toxic symptoms in slugs, reduces the concentrations of neurotransmitters (Noradrenaline, 5-HT (HY-B1473A)) in the mouse brain, and induces lethal clonic-tonic convulsions in mice.

Dihydroartemisinin (mixture of α and β isomers) is an anti-malaria and anticancer agent, as well as an active metabolite of artemisinin and its derivatives. Dihydroartemisinin exerts anticancer effects through various molecular mechanisms, such as inhibiting proliferation, inducing apoptosis, inhibiting tumor metastasis and angiogenesis, promoting immune function, inducing autophagy and endoplasmic reticulum stress.

KKL-40 is a small molecule inhibitor that targets the trans-transcription process and is effective against methicillin-sensitive and -resistant Staphylococcus aureus (S. aureus) as well as other Gram-positive pathogens including vancomycin-resistant Enterococcus faecium, Bacillus subtilis, and Streptococcus pyogenes. KKL-40 synergizes with the human antimicrobial peptide LL-37 to inhibit S. aureus, but does not synergize with other antibiotics such as daptomycin, kanamycin, or erythromycin. Trans-transcription is an extreme form of recoding, and KKL-40 inhibits trans-transcription but is nontoxic to HeLa cells.

L-742001 hydrochloride is an influenza virus PA endonuclease inhibitor, with an EC₉₀ of 4.3 μM for vRNP activity in HEK293T cells.

Amitraz-d₃ is the deuterium labeled Amitraz. Amitraz is a non-systemic acaricide and insecticide, with alpha-adrenergic agonist activity, interaction with octopamine receptors of the central nervous system and inhibition of monoamine oxidases and prostaglandin synthesis.

4-Methylcinnamic acid is a cinnamic acid derivative with antifungal activity. 4-Methylcinnamic acid can overcome the tolerance of glutathione reductase mutants to 4-Methoxycinnamic acid (HY-N1387). When 4-Methylcinnamic acid is used in combination with traditional antifungal agents, it can reduce their minimum inhibitory concentrations. 4-Methylcinnamic acid can act as an intervention catalyst to enhance the efficacy of traditional antifungal agents and has application potential in targeting fungal cell wall disruption and controlling drug-resistant fungi.

Gepotidacin mesylate hydrate is an orally active triazaacenaphthylene antibiotic and bacterial type II topoisomerase inhibitor. Gepotidacin mesylate hydrate inhibits bacterial DNA replication by blocking topoisomerase enzymes. Gepotidacin mesylate hydrate selectively inhibits topoisomerase IV and the B subunit of DNA gyrase.

Ceftizoxime sodium (SKF-88373) is third generation cephalosporin effective against Gram-negative and Gram-positive bacteria. It binds penicillin-binding proteins (PBPs) and inhibits the bacterial cell wall synthesis.