Metabolic Disease

Tridecanedioic acid (Standard) is the analytical standard of Tridecanedioic acid (HY-128421). This product is intended for research and analytical applications. Tridecanedioic acid is an endogenous metabolite. Tridecanedioic acid is an endogenous metabolite. Tridecanedioic acid is related to the metabolic regulation of non-alcoholic fatty liver disease (NASH) and may be an important node molecule in the intestinal microbiota-host metabolism interaction network. Tridecanedioic acid is significantly accumulated in tolerant cabbage-type rapeseed varieties and has a lower content in sensitive varieties. It plays an important role in the defense response against the infection of the small cabbage moth (Plutella xylostella). Tridecanedioic acid can be used as a biomarker for plant insect resistance or a diagnostic marker for metabolic diseases.

Malabaricone B, a naturally occurring plant phenolic, is an orally active α-glucosidase inhibitor with an IC₅₀ of 63.7 µM. Malabaricone B has anticancer, antimicrobial, anti-oxidation and antidiabetic activities.

Methyl tetracosanoate (Methyl lignocerate) is a fatty acid methyl ester with anti-diabetic activity.

β-Alanine-¹⁵N is the ¹⁵N-labeled β-Alanine. β-Alanine is a non-essential amino acid that is shown to be metabolized into carnosine, which functions as an intracellular buffer.

SKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP.

Aureusidin is a flavonoid compound that is isolated and extracted from Antirrhinum majus and exhibits oral activity. Aureusidin possesses antioxidant, neuroprotective, and anti-inflammatory properties. Aureusidin directly targets and binds MD2 and Caspase-3 with high affinity, synergistically inhibits the TLR4/NF-κB inflammatory pathway and GSDME-mediated pyroptosis, and activates the Nrf2/HO-1 antioxidant axis via the ROS/MAPKs pathway. Aureusidin is a bovine liver arginase inhibitor with an IC₅₀ of 57.1 µM. Aureusidin is used for research on inflammation-related diseases (osteoarthritis), acute liver injury, and endothelial dysfunction.

α-Ketoglutarate dehydrogenase, Porcine (EC 1.2.4.2) is an enzyme complex that functions in the citric acid cycle.

Cimbuterol-d₉ is the deuterium labeled Cimbuterol (HY-131105). Cimbuterol is a β-adrenergic agonist. β-adrenergic agonists act as bronchodilators and tocolytics. β-adrenergic agonists promote growth.

CJ033466 is a novel and selective 5-HT₄ receptor partial agonist with an EC₅₀ of 9 nM and has gastroprokinetic effect.

Danshenxinkun B is an antioxidative component of tanshen (Salvia miltiorhiza Bung) .

D-γ-Glu-Tyr is a D-isomer of γ-Glu-Tyr (HY-P4633), the difference being the γ-Glu content.γ-Glu-Tyr, a competitive inhibitor of dipeptidyl peptidase-IV (DPP-IV) (IC₅₀=6.77 mM), is a potentially functional component of the type 2 diabetes diet.

Homovanillic acid-d₂ (Vanilacetic acid-d₂) is the deuterium labeled Homovanillic acid (HY-N0384). Homovanillic acid (Vanilacetic acid) is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

MB-07344 sodium is a potent thyroid hormone receptor (TR)-β agonist with a K_i of 2.17 nM. MB-07344 sodium has additive cholesterol lowering activity in combination with Atorvastatin (HY-B0589) in rabbits, dogs and monkeys.

Clathrin-IN-2 is potent inhibitor of clathrin mediated endocytosis (CME) with an IC₅₀ value of 2.3 μM. Clathrin-IN-2 also has inhibitiory for dyn I GTPase with an IC₅₀ value of 7.7 μM.

YW1128 (compound 3a) is a potent Wnt/β-Catenin inhibitor. YW1128 induces the proteasome degradation of β-catenin and subsequent inhibits the Wnt/β-catenin signaling in cells. YW1128 significantly decreases hepatic lipid accumulation. YW1128 improves glucose tolerance of high fat diet-fed mice without noticeable toxicity. YW1128 down regulates the genes involved in the glucose and fatty acid anabolism.

22:0 Coenzyme A triammonium is a derivative of coenzyme A (CoA), where CoA is combined with a 22-carbon saturated fatty acid (behenic acid, also known as docosanoic acid). 22:0 Coenzyme A triammonium can serve as a substrate for AmFAR1.

(R)-Verapamil (Dexverapamil) is an optically enantiomer of the oral-active Verapamil (HY-14275). (R)-Verapamil has a relatively low affinity for L-type calcium channels (Ca_v1.2) (IC₅₀ > 300 μM), and its IC₅₀ for sodium channels (sodium channel) is 3.19 μM. (R)-Verapamil exhibits SSTR2 agonistic activity, with an EC₅₀ of 1.3 μM. (R)-Verapamil significantly downregulates the expression of TXNIP protein in diabetic mouse models and significantly inhibits β-cell apoptosis (apoptosis), effectively controlling blood sugar. (R)-Verapamil can be used as a PET tracer for the function of P-glycoprotein (P-gp).

3-N-Propylphenol is a small phenolic derivative containing a hydroxyl aryl group that competitively inhibits the binding of the peptide to pancreatic-specific protein disulfide isomerase (PDIp). 3-Propylphenol can be used for research on pancreatic-related diseases.

Marmesinin ((-)-Marmesinin; Ammijin) is an orally active furanocoumarin glycoside that enhances insulin secretion by inhibiting CYP1A2/CYP3A4 and Aldose Reductase, and modulating the PPARγ/PDX-1/IRS-2 pathway, while also exhibiting anti-inflammatory, antioxidant, and myocardial membrane-stabilizing effects. Marmesinin is used in research on type 2 diabetes, diabetic complications, myocardial injury, neurodegenerative diseases, and malaria.