5-HT Receptor
Serotonin Receptor; 5-hydroxytryptamine Receptor
5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems. Type: 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7. They mediate both excitatory and inhibitory neurotransmission. The serotonin receptors are activated by the neurotransmitter serotonin, which acts as their natural ligand. The serotonin receptors modulate the release of many neurotransmitters, as well as many hormones. The serotonin receptors influence various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, andthermoregulation. The serotonin receptors are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics, anorectics,antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens.
5-HT Receptor Isoform Specific Products
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5-HT Receptor
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5-HT1 Receptor
(454)
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5-HT2 Receptor
(489)
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5-HT3 Receptor
(35)
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5-HT4 Receptor
(19)
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5-HT5 Receptor
(14)
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5-HT6 Receptor
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5-HT7 Receptor
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All Product Categories
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5-HT Receptor Inhibitors
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5-HT Receptor Agonists
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5-HT Receptor Antagonists
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5-HT Receptor Activators
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5-HT Receptor Modulators
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5-HT Receptor Inducers
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5-HT Receptor Controls
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5-HT Receptor Ligands
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5-HT Receptor Related Products (1770)
Related Products (1770)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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5-HT Receptor Isoform Comparison
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GYKI-46903
0 ImagesCat. No.: HY-116554CAS No.: 142999-59-5GYKI-46903 is a non-competitive antagonist for 5-HT3 receptor, with the pIC50 of 6.91.
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Granisetron-d6 (Standard)
0 ImagesCat. No.: HY-B0071S2CAS No.: 1224925-80-7Synonyms: BRL 43694-d6 (Standard)Granisetron-d6 (BRL 43694-d6) is deuterium labeled Granisetron. Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.
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Cinanserin
0 ImagesCinanserin (SQ 10643) is a potent and selective 5-HT2 antagonist with Ki values of 41, 3500 nM for 5-HT2, 5-HT1, respectively. Cinanserin also is a SARS-CoV 3CLpro inhibitor with an KD value of 49.4, 18.2 µM for SARS-CoV 3CLpro, HCoV-229E 3CLpro, respectively. Cinanserin reduces systemic burn edema levels.
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5-HT4 antagonist 1 (Standard)
0 ImagesCat. No.: HY-100170RCAS No.: 261766-73-85-HT4 antagonist 1 (Standard) is the analytical standard of 5-HT4 antagonist 1 (HY-100170). This product is intended for research and analytical applications. 5-HT4 antagonist 1 is a 5-HT4 receptor antagonist with a pKi of 9.6.
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Perphenazine (Standard)
0 ImagesPerphenazine (Standard) is the analytical standard of Perphenazine. This product is intended for research and analytical applications. Perphenazine is an orally active dopamine receptor and histamine-1 receptor antagonist, with Ki values of 0.56 nM (D2), 0.43 nM (D3), 6 nM (5-HT2A), respectively. Perphenazine also binds to Alpha-1A adrenergic receptor. Perphenazine inhibits cancer cell proliferation, and induces apoptosis. Perphenazine can be used in the research of mental disease, cancer, inflammation.
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SCH-23390 hydrobromide (Standard)
0 ImagesCat. No.: HY-19545ARCAS No.: 125941-87-9Synonyms: R-(+)-SCH-23390 hydrochloride (Standard)SCH-23390 hydrochloride (Standard) is the analytical standard of SCH-23390 hydrochloride (HY-19545A). This product is intended for research and analytical applications. SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively. SCH-23390 hydrochloride is a potent and high efficacy human 5-HT2C receptor agonist with a Ki of 9.3 nM. SCH-23390 hydrochloride also binds with high affinity to the 5-HT2 and 5-HT1C receptors. SCH-23390 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC50 of 268 nM.
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(R)-Viloxazine-d5 hydrochloride
0 ImagesCat. No.: HY-125784ASCAS No.: 1246815-04-2Synonyms: (R)-Viloxazin-d5 hydrochloride; (R)-Emovit-d5 hydrochloride(R)-Viloxazine-d5 hydrochloride ((R)-Viloxazin-d5 hydrochloride; (R)-Emovit-d5 hydrochloride) is the deuterated-labeled (R)-Viloxazine hydrochloride (HY-125784A). (R)-Viloxazine hydrochloride is the less active R-isomer of Viloxazine hydrochloride (HY-125784). (R)-Viloxazine hydrochloride can be used in the research of depression.
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Methiothepin mesylate (Standard)
0 ImagesCat. No.: HY-107836RCAS No.: 74611-28-2Synonyms: Metitepine mesylate (Standard); Ro 8-6837 mesylate (Standard)Methiothepin (mesylate) (Standard) is the analytical standard of Methiothepin (mesylate). This product is intended for research and analytical applications. Methiothepin (Metitepine) mesylate is a potent and non-selective 5-HT2 receptor antagonist, with pKds of 7.10 (5-HT1A), 7.28 (5HT1B), 7.56 (5HT1C), 6.99 (5HT1D), 7.0 (5-HT5A), 7.8 (5-HT5B), 8.74 (5-HT6), and 8.99 (5-HT7), and pKis of 8.50 (5HT2A), 8.68 (5HT2B), and 8.35 (5HT2C).
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2-Methyl-N,N-dimethyltryptamine
0 Images2-Methyl-N,N-dimethyltryptamine (2,N,N-TMT, compound 15) has binding affinity for serotonin (5-HT) receptor, with the pA2 of 6.04. 2-Methyl-N,N-dimethyltryptamine plays an important role in neurological disease research.
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WAY-100635 (Standard)
0 ImagesCat. No.: HY-10349RCAS No.: 162760-96-5WAY-100635 (Standard) is the analytical standard of WAY-100635. This product is intended for research and analytical applications. WAY-100635 is a potent and selective 5-HT1A Receptor antagonist with a pIC50 of 8.87, an apparent pA2 of 9.71. WAY-100635 is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC50 value of 0.91 nM and Ki value of 0.39 nM. WAY-100635 has pIC50 values for 5-HT1A and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 is also a potent dopamine D4 receptor agonist.
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Ketanserin tartrate (Standard)
0 ImagesSynonyms: R41468 tartrate (Standard)Ketanserin (tartrate) (Standard) is the analytical standard of Ketanserin (tartrate). This product is intended for research and analytical applications. Ketanserin (R41468) tartrate is a selective 5-HT2 receptor antagonist. Ketanserin tartrate also blocks hERG current (IhERG) in a concentration-dependent manner (IC50=0.11 μM).
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Agomelatine (L(+)-Tartaric acid)
0 ImagesSynonyms: S-20098 L(+)-Tartaric acidAgomelatine L(+)-Tartaric acid (S-20098 L(+)-Tartaric acid) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Agomelatine L(+)-Tartaric acid is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively.
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SB-649915
0 ImagesCat. No.: HY-108252CAS No.: 420785-70-2SB-649915 is a potent 5-HT1A/1B autoreceptor antagonist, with the pKi values of 8.6, 8.0, respectively and 5-HT reuptake inhibitor in native tissue systems and palys an important role in antidepressant research.
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TCB2 (Standard)
0 ImagesCat. No.: HY-103102RCAS No.: 912342-28-0
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Diclofensine hydrochloride (Standard)
0 ImagesCat. No.: HY-18610RCAS No.: 34041-84-4Synonyms: Ro 8-4650 hydrochloride (Standard)Diclofensine (Ro 8-4650) hydrochloride (Standard) is the analytical standard of Diclofensine hydrochloride. This product is intended for research and analytical applications. Diclofensine hydrochloride is an orally active neuronal monoamine uptake inhibitor. Diclofensine hydrochloride blocks the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3 and 3.7 nM, respectively. Diclofensine hydrochloride potentiates norepinephrine-induced hypertension and attenuates Tyramine (HY-W007606)-induced hypertension. Diclofensine hydrochloride produces psychostimulant and mood-elevating effects without causing sudden disappearance or withdrawal reactions. Diclofensine hydrochloride can be used in the research of moderate to severe depression.
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Dehydroaripiprazole-d8
0 ImagesCat. No.: HY-100665SCAS No.: 2749328-53-6Synonyms: OPC-14857-d8; DM-14857-d8Dehydroaripiprazole-d8 is deuterium labeled Dehydroaripiprazole. Dehydroaripiprazole (OPC-14857) is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D6 forming mainly Dehydroaripiprazole. Dehydroaripiprazole has with antipsychotic activity equivalent to Aripiprazole.
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2-(2-Methoxyphenoxy)ethylamine hydrochloride (Standard)
0 ImagesCat. No.: HY-107847RCAS No.: 64464-07-92-(2-Methoxyphenoxy)ethylamine hydrochloride (Standard) is the analytical standard of 2-(2-Methoxyphenoxy)ethylamine (hydrochloride) (HY-107847). This product is intended for research and analytical applications. 2-(2-Methoxyphenoxy)ethylamine hydrochloride (Compound 2b) is a mixed agonist/antagonist. 2-(2-Methoxyphenoxy)ethylamine hydrochloride is a5-HT1A receptor partial agonist and a α1-adrenergic receptor antagonist. 2-(2-Methoxyphenoxy)ethylamine hydrochloride can be used for neurological diseases research, such as anxiety, depression and psychosis.
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Lurasidone (Standard)
0 ImagesSynonyms: SM-13496 (Standard)Lurasidone (Standard) is the analytical standard of Lurasidone. This product is intended for research and analytical applications. Lurasidone (SM-13496) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (SM-13496) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM.
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Setiptiline maleate (Standard)
0 ImagesSynonyms: MO-8282 (Standard)Setiptiline (maleate) (Standard) is the analytical standard of Setiptiline (maleate). This product is intended for research and analytical applications. Setiptiline maleate (MO-8282 maleate) is a serotonin receptor antagonist. Setiptiline maleate is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline maleate acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine.
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LY266097 hydrochloride (Standard)
0 ImagesCat. No.: HY-103094RCAS No.: 172895-39-5LY266097 hydrochloride (Standard) is the analytical standard of LY266097 hydrochloride (HY-103094). This product is intended for research and analytical applications. LY266097 hydrochloride is a selective 5-HT2B receptor antagonist with pKis of 7.7, 9.8, and 7.6 for 5-HT2A, 5-HT2B, 5-HT2C, respectively. 5-HT2B receptor blockade contributes to the research in depression.
