5-HT₇ Receptor Antagonist

5-HT₇ Receptor Antagonists (25):

Cat. No.	Product Name	Effect	Purity

HY-15370A

SB-269970 hydrochloride	Antagonist	99.15%
SB-269970 hydrochloride is a potent, selective and brain-penetrant 5-HT7 receptor antagonist with a pK_i of 8.3.

HY-A0077

Perphenazine	Antagonist	99.72%
Perphenazine is an orally active dopamine receptor and histamine-1 receptor antagonist, with K_i values of 0.56 nM (D2), 0.43 nM (D3), 6 nM (5-HT2A), respectively.

HY-107836

Methiothepin mesylate	Antagonist	99.32%
Methiothepin mesylate is a potent and non-selective 5-HT₂ receptor antagonist, with pK_ds of 7.10 (5-HT_1A), 7.28 (5HT_1B), 7.56 (5HT_1C), 6.99 (5HT_1D), 7.0 (5-HT_5A), 7.8 (5-HT_5B), 8.74 (5-HT₆), and 8.99 (5-HT₇), and pK_is of 8.50 (5HT_2A), 8.68 (5HT_2B), and 8.35 (5HT_2C).

HY-103112B

SB 243213	Antagonist	98.62%
SB 243213 is an orally active, selective and high-affinity 5-HT_2C receptor antagonist with a pK_i of 9.37 and a pK_b of 9.8 for human 5-HT_2C receptor.

HY-10121

Asenapine	Antagonist	99.93%
Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pK_i: 8.4-10.5), adrenoceptors (pK_i: 8.9-9.5), dopamine receptors (pK_i: 8.9-9.4) and histamine receptors (pK_i: 8.2-9.0).

HY-B1033

Metergoline	Antagonist	99.88%
Metergoline is a serotonin (5-HT) receptor and dopamine receptors antagonist, with pK_is of 8.64, 8.75 and 8.75 for 5-HT_2A, 5-HT_2B and 5-HT_2C, respectively.

HY-11100

Asenapine maleate	Antagonist	99.95%
Asenapine maleate is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and D2 antagonist with K_i values of 0.03-4.0 nM, 1.3nM, respectively, and an antipsychotic.

HY-19889

JNJ-18038683	Antagonist	99.76%
JNJ-18038683 is a 5-Hydroxytryptamine Type 7 (5-HT₇) receptor antagonist, with pK_is of 8.19, 8.20 for rat and human 5-HT₇ in HEK293 cells, respectively.

HY-U00443

SB 258719	Antagonist	99.04%
SB 258719 is a selective 5-HT₇ receptor antagonist with high affinity (pK_i=7.5) for the receptor.

HY-17410

Iloperidone	Antagonist	99.97%
Iloperidone (HP 873) is a D₂/5-HT₂ receptor antagonist.

HY-16567

Asenapine hydrochloride	Antagonist	98.76%
Asenapine hydrochloride, an antipsychotic, is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and Dopamine (D₂, D₃, D₄) receptor antagonist with K_i values of 0.03-4.0 nM for 5-HT and 1.3, 0.42, 1.1 nM for Dopamine receptor, respectively.

HY-14336A

SB 271046 Hydrochloride	Antagonist	98.64%
SB 271046 Hydrochloride (SB 271046A) is a potent, selective and orally active 5-HT6 receptor antagonist with pK_i of 9.02, 8.55, and 8.81 for rat, pig and human, respectively.

HY-14348

GSK163090	Antagonist	99.77%
GSK163090 is a potent, selective and orally active 5-HT_1A/1B/1D receptor antagonist with pK_i values of 9.4/8.5/9.7, respectively.

HY-103112A

SB 243213 dihydrochloride	Antagonist	≥99.0%
SB 243213 dihydrochloride is an orally active, selective and high-affinity 5-HT_2C receptor antagonist with a pK_i of 9.37 and a pK_b of 9.8 for human 5-HT_2C receptor.

HY-103112

SB 243213 hydrochloride	Antagonist
SB 243213 hydrochloride is an orally active, selective and high-affinity 5-HT_2C receptor antagonist with a pK_i of 9.37 and a pK_b of 9.8 for human 5-HT_2C receptor.

HY-101622

5-HT6/7 antagonist 1	Antagonist
5-HT6/7 antagonist 1 is a multifunctional ligand that antagonizes 5-HT6/7/2A and D2 receptors, without interacting with M1 receptors and hERG channels.

HY-15370

SB-269970	Antagonist
SB-269970 is a potent, selective and brain-penetrant 5-HT7 receptor antagonist with a pK_i of 8.3.

HY-103123

SB 258719 hydrochloride	Antagonist
SB 258719 hydrochloride is a selective 5-HT₇ receptor antagonist displayed high affnity (pK_i=7.5) for the receptor.

HY-136678A

SB 258741 hydrochloride	Antagonist
SB 258741 hydrochloride is a specific 5-HT₇ receptor antagonist and can be used for the research of schizophrenia.

HY-144764

5-HT1A antagonist 1	Antagonist
5-HT1A antagonist 1 (compound 6f) is a potent and selective antagonist of 5-HT_1A receptor, with a K_i of 35 nM.

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