1. Signaling Pathways
  2. GPCR/G Protein
  3. Adenosine Receptor
  4. Adenosine A2A receptor (A2AR) Isoform
  5. Adenosine A2A receptor (A2AR) Antagonist

Adenosine A2A receptor (A2AR) Antagonist

Adenosine A2A receptor (A2AR) Antagonists (17):

Cat. No. Product Name Effect Purity
  • HY-14858
    Derenofylline
    Antagonist ≥99.0%
    Derenofylline (SLV 320) is a potent, selective and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM and 398 nM for human A1, A3 and A2A receptors respectively.
  • HY-148088
    M1069
    Antagonist
    M1069 is a selective and orall active, dual A2A/A2B adenosine receptor antagonist with a selectivity of >100 fold against the A1 and A3 receptors.
  • HY-144064
    Adenosine receptor antagonist 2
    Antagonist 99.37%
    Adenosine receptor antagonist 2 is an orally active A2a/A2b adenosine receptor antagonist with IC50s of 1 nM and 3 nM, respectively.
  • HY-147544
    A1AR antagonist 5
    Antagonist
    A1AR antagonist 5 (compound 20) is a potent and selective A1AR (A1 adenosine receptor) antagonist, with a pIC50 of 5.83 and a pKi of 6.11.
  • HY-105003
    ST 1535
    Antagonist
    ST 1535 is a potent and orally active A2A adenosine receptor antagonist.
  • HY-151139
    LJ-4517
    Antagonist
    LJ-4517 is a potent A2AAR antagonist, with a Ki of 18.3 nM.
  • HY-103162
    ANR94
    Antagonist
    ANR94 is a potent and selective adenosine A2A receptor (AA2AR) antagonist with an Ki of 46 nM for hAA2AR.
  • HY-147543
    A1AR antagonist 4
    Antagonist
    A1AR antagonist 4 (compound 22) is a potent and selective A1AR (A1 adenosine receptor) antagonist, with a pIC50 of 5.51 and a pKi of 6.29.
  • HY-103174
    MRS1334
    Antagonist
    MRS1334 is a potent and selective human adenosine A3 receptor antagonist with Kis of 2.69 nM, >100 nM, >100 nM for hA3, rA1, rA2A, respectively.
  • HY-147545
    A1AR antagonist 6
    Antagonist
    A1AR antagonist 6 (compound 15) is a potent and selective A1AR (A1 adenosine receptor) antagonist, with a pIC50 of 6.38 and a pKi of 7.13.
  • HY-148076
    A2A receptor antagonist 3
    Antagonist
    A2A receptor antagonist 3 (Example 92) is an adenosine A2a receptor antagonist with a Ki of 0.4 nM.
  • HY-146979
    hA2A/hCA XII modulator 1
    Antagonist
    hA2A/hCA XII modulator 1 (compound 14), a triazolopirazine, is a potent hA2A adenosine receptor (hA2AAR) antagonist with Kis of 6.4 nM, 4.819 μM, >30 μM for hA2AAR, hA1AR, hA3AR, respectively.
  • HY-103164
    (E)-8-(3-Chlorostyryl)caffeine
    Antagonist
    (E)-8-(3-Chlorostyryl)caffeine is a selective adenosine A2A receptor antagonist.
  • HY-144672
    A2A receptor antagonist 2
    Antagonist
    A2A receptor antagonist 2 (Compound 57) is a potent, highly selective adenosine A2A receptor (A2AR) antagonist with an IC50 of 8.3 nM.
  • HY-103175
    PSB36
    Antagonist
    PSB36 is a potent and selective antagonist of adenosine A1 receptor, with Kis 0.12 nM, 187 nM, 552 nM, 2300 nM, and 6500 nM for rA1, hA2B, rA2A, hA3 and rA3 receptors respectively.
  • HY-147541
    A2A/A3 AR antagonist-1
    Antagonist
    A2A/A3 AR antagonist-1 (compound 23) is a dual A2A/A3 adenosine receptor (AR) fluorescent ligand, with Kis of 90 nM and 31.8 nM for hA2A AR and hA3 AR, respectively.
  • HY-141865
    Adenosine receptor antagonist 1
    Antagonist
    Adenosine receptor antagonist 1 is a A2aR-selective antagonist with an IC50 of 0.29 nM and displays 14-fold more selective for A2aR than A2bR.