E3 Ligase Ligand-Linker Conjugates
E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc. MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.
E3 Ligase Ligand-Linker Conjugates Isoform Specific Products
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E3 Ligase Ligand-Linker Conjugates Related Products (1117)
Related Products (1117)
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Antibodies (1)
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E3 Ligase Ligand-Linker Conjugates Isoform Comparison
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Pomalidomide-C11-NH2
0 ImagesCat. No.: HY-153337CAS No.: 2648285-39-4
![(S,R,S)-AHPC-CO-bicyclo[2.2.2]octane-CHO](https://file.medchemexpress.com/product_pic/hy-159537.gif "Click to View (S,R,S)-AHPC-CO-bicyclo[2.2.2]octane-CHO Product Detail")
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Thalidomide-O-C4-NH2
0 ImagesCat. No.: HY-130948CAS No.: 1957235-96-9Thalidomide-O-C4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
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Thalidomide-2,6-diazaspiro[3.4]octane-C-Pip-boc
![Thalidomide-2,6-diazaspiro[3.4]octane-C-Pip-boc](https://file.medchemexpress.com/product_pic/hy-161209.gif "Click to View Thalidomide-2,6-diazaspiro[3.4]octane-C-Pip-boc Product Detail")
0 ImagesCat. No.: HY-161209Thalidomide-2,6-diazaspiro[3.4]octane-C-Pip-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-2,6-diazaspiro[3.4]octane-C-Pip-boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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E3 Ligase Ligand-linker Conjugate 242
0 ImagesCat. No.: HY-189227CAS No.: 2504234-62-0E3 Ligase Ligand-linker Conjugate 242 (compound m51) is an E3 ligase-ligand conjugate that serves as an intermediate for the synthesis of bifunctional degraders, such as BRD9 PROTAC/IMiD degraders. E3 Ligase Ligand-linker Conjugate 242 can be used for the construction of PROTAC molecules and related research.
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(S,R,S)-AHPC-CO-C9-NH2 hydrochloride
0 ImagesCat. No.: HY-160555ACAS No.: 2376139-50-1(S,R,S)-AHPC-CO-C9-NH2 (hydrochloride) is a von Hippel-Lindau (VHL) amino building block that can be used to synthesize E3 ligase ligands required for PROTACs..
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Pomalidomide-5-C7-NH2
0 ImagesCat. No.: HY-174869CAS No.: 2412056-40-5Pomalidomide-5-C7-NH2 is an E3 ligase ligand-linker conjugate that incorporates the 5-Aminothalidomide (HY-W023573) based CRBN ligand (HY-103596) and linker. Pomalidomide-5-C7-NH2 can be used for synthesis of PROTAC BT-O2C (HY-174866).
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(1R,5S)-Thalidomide-3,8-diazabicyclo[3.2.1]octane-Boc
![(1R,5S)-Thalidomide-3,8-diazabicyclo[3.2.1]octane-Boc](https://file.medchemexpress.com/product_pic/hy-163230.gif "Click to View (1R,5S)-Thalidomide-3,8-diazabicyclo[3.2.1]octane-Boc Product Detail")
0 ImagesCat. No.: HY-163230(1R,5S)-Thalidomide-3,8-diazabicyclo[3.2.1]octane-Boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. (1R,5S)-Thalidomide-3,8-diazabicyclo[3.2.1]octane-Boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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(S)-Thalidomide-O-(1S,3r)-C4H4-N(Me)-Pip-C2-O-C-boc
0 ImagesCat. No.: HY-161183(S)-Thalidomide-O-(1S,3r)-C4H4-N(Me)-Pip-C2-O-C-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. (S)-Thalidomide-O-(1S,3r)-C4H4-N(Me)-Pip-C2-O-C-boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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E3 Ligase Ligand-linker Conjugate 227
0 ImagesCat. No.: HY-182085CAS No.: 3039540-25-2
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Pomalidomide-5-C3-NH2 hydrochloride
0 ImagesCat. No.: HY-155259Pomalidomide-5-C3-NH2 hydrochloride is the Pomalidomide (HY-10984)-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-C3-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC.
