E3 Ligase Ligand-Linker Conjugates
E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc. MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.
E3 Ligase Ligand-Linker Conjugates Isoform Specific Products
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E3 Ligase Ligand-Linker Conjugates Related Products (1117)
Related Products (1117)
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Antibodies (1)
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E3 Ligase Ligand-Linker Conjugates Isoform Comparison
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E3 Ligase Ligand-linker Conjugate 54
0 ImagesCat. No.: HY-162204CAS No.: 2229725-33-9E3 Ligase Ligand-linker Conjugate 54 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker Conjugate 54 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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Pomalidomide-5-C5-NH2 hydrochloride
0 ImagesCat. No.: HY-155261CAS No.: 2925306-39-2Pomalidomide-5-C5-NH2 hydrochloride is the Pomalidomide (HY-10984)-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-C5-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC.
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Thalidomide-5-O-C7-NH2 hydrochloride
0 ImagesCat. No.: HY-149564Purity: 98.13%Thalidomide-5-O-C7-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-O-C7-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs.
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Thalidomide-4-O-C12-NH2 hydrochloride
0 ImagesCat. No.: HY-149574Thalidomide-4-O-C12-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-4-O-C12-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs.
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E3 ligase Ligand-Linker Conjugate 42
0 ImagesCat. No.: HY-157597E3 ligase Ligand-Linker Conjugate 42 is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. E3 ligase Ligand-Linker Conjugate 42 can be used as a key intermediate for the synthesis of complete PROTAC molecules.
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Pomalidomide-5-C4-acid
0 ImagesCat. No.: HY-184581CAS No.: 2412056-33-6Pomalidomide-5-C4-acid is an E3 ligase ligand-linker conjugate that can be used for PROTAC synthesis, such as PROTAC BRAF-V600E degrader-2 (HY-137488).
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Thalidomide-5-O-C5-NH2 hydrochloride
0 ImagesCat. No.: HY-149562CAS No.: 2761385-94-6Thalidomide-5-O-C5-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-O-C5-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs.
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E3 Ligase Ligand-linker Conjugate 94
0 ImagesCat. No.: HY-157637E3 Ligase Ligand-linker Conjugate 94 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker Conjugate 94 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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Lenalidomide-amide-pimelic acid
0 ImagesCat. No.: HY-176430CAS No.: 2353496-83-8Lenalidomide-amide-pimelic acid is an E3 ligase ligand-linker conjugate that incorporates the Lenalidomide (HY-A0003) based CRBN ligand and Linker (HY-Y1139). Lenalidomide-amide-pimelic acid can be used for synthesis of PROTAC MNK1 degrader-1 (HY-176428).
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Lenalidomide-7-bromohept-1-yne
0 ImagesCat. No.: HY-169181CAS No.: 2619511-78-1
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CRBN ligand-903-trans-1,4-cyclohexanediamine-Boc
0 ImagesCat. No.: HY-183819CRBN ligand-903-trans-1,4-cyclohexanediamine-Boc is a cereblon (CRBN) ligand and ligase binding ligand (LBL) used in synthesis of p300 protein degraders, also designated as compound 28f.CRBN ligand-903-trans-1,4-cyclohexanediamine-Boc is tert-butyl (trans-4-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-1-methoxy-2-naphthamido)cyclohexyl)carbamate, a CRBN ligand intermediate for synthesis of degrader 28.
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Thalidomide-4-O-C13-NH2 hydrochloride
0 ImagesCat. No.: HY-149575Thalidomide-4-O-C13-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-4-O-C13-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs.
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3-(7-Methoxy-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione-azacyclohexane-C-piperazine-CO
0 ImagesCat. No.: HY-1788323-(7-Methoxy-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione-azacyclohexane-C-piperazine-CO is a synthesized E3 ligase ligand-linker conjugate that can be used to synthesize PROTAC LRRK2 Degrader-4 (HY-178796). PROTAC LRRK2 Degrader-4 is a potent LRRK2 PROTAC degrader with anti-neuroinflammatory activity.
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(S)-E3 Ligase Ligand-linker Conjugate 175
0 ImagesCat. No.: HY-172738A(S)-E3 Ligase Ligand-linker Conjugate 175 is a conjugate of an E3 ligase ligand and linker, which can be used for the synthesis of PROTACs, such as PRT3789 epimer (HY-159607A).
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Thalidomide-O-C4H4-N(Me)-piperidine-boc
0 ImagesCat. No.: HY-161204Thalidomide-O-C4H4-N(Me)-piperidine-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-O-C4H4-N(Me)-piperidine-boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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E3 ligase Ligand-Linker Conjugate 34
0 ImagesCat. No.: HY-162195CAS No.: 2682113-65-9E3 ligase Ligand-Linker Conjugate 34 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase Ligand-Linker Conjugate 34 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
