E3 Ligase Ligand-Linker Conjugates
E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc. MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.
E3 Ligase Ligand-Linker Conjugates Isoform Specific Products
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E3 Ligase Ligand-Linker Conjugates Related Products (1117)
Related Products (1117)
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Antibodies (1)
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E3 Ligase Ligand-Linker Conjugates Isoform Comparison
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Thalidomide-NH-amido-PEG2-C2-NH2 hydrochloride
0 ImagesCat. No.: HY-138855ACAS No.: 2983036-91-3Thalidomide-NH-amido-PEG2-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
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JQ-1 carboxylic acid-PEG3-C2-NH2 hydrochloride
0 ImagesCat. No.: HY-169150ACAS No.: 2241669-80-5JQ-1 carboxylic acid-PEG3-C2-NH2 (hydrochloride) is a E3 ligase ligand-linker conjugate that can be used in the synthesis of PROTACT.
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Thalidomide-O-amido-C7-NH2
0 ImagesCat. No.: HY-W940797CAS No.: 2716123-52-1Thalidomide-O-amido-C7-NH2 is a E3 ligase ligand-linker conjugate that can be used in the synthesis of PROTACT.
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Thalidomide-NHCH2-Ph-pyrimidine-NH2
0 ImagesCat. No.: HY-161500Thalidomide-NHCH2-Ph-pyrimidine-NH2 is a conjugate of E3 ligase ligand and linker, which is consisted of a Thalidomide (HY-14658) and a Linker Boc-NHCH2-Ph-pyrimidine-NH2 (HY-161499). Thalidomide-NHCH2-Ph-pyrimidine-NH2 is utilized for synthesis of PROTAC molecule XYD198 (HY-161498).
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Thalidomide-azetidine-CH-piperazineethanol
0 ImagesCat. No.: HY-163238Thalidomide-azetidine-CH-piperazineethanol is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-azetidine-CH-piperazineethanol can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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Pomalidomide-C2-NHCO-C7-NHBoc
0 ImagesCat. No.: HY-187177CAS No.: 3067348-77-7
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E3 Ligase Ligand-linker Conjugate 93
0 ImagesCat. No.: HY-157636E3 Ligase Ligand-linker Conjugate 93 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker Conjugate 93 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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VHL Ligand 41-CO-C10-NH2
0 ImagesCat. No.: HY-184671CAS No.: 2313233-96-2VHL Ligand 41-CO-C10-NH2 is an E3 ligase ligand-linker conjugate for PROTAC synthesis. VHL Ligand 41-CO-C10-NH2 is the E3 ligase ligand-linker conjugate moiety of PROTAC BRD4 Degrader-3 (HY-135558).
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CDLI-5
0 ImagesCat. No.: HY-159665CAS No.: 3047549-85-6CDLI-5 is a cereblon degrader-linker conjugate, and can be used for synthesis of cereblon degrader antibody conjugates (cDACs).
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VH032-thiol-C6-NH2
0 ImagesCat. No.: HY-111824CAS No.: 2098836-63-4Synonyms: VHL Ligand-Linker Conjugates 14; E3 ligase Ligand-Linker Conjugates 29
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Thalidomide-5-PEG2-NH2 hydrochloride
0 ImagesThalidomide-5-PEG2-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-PEG2-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs.
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Thalidomide-NH-amido-C4-NH2 (hydrochloride)
0 ImagesCat. No.: HY-134984ACAS No.: 2983057-91-4Thalidomide-NH-amido-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
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LCL-PEG3-N3 hydrochloride
0 ImagesCat. No.: HY-139999ACAS No.: 3033849-91-8LCL-PEG3-N3 (hydrochloride) is a decoy oligonucleotide ligand for E3 ligase which can be used for developing chimeric molecules LCL-ER(dec), degrading the estrogen receptor. LCL-PEG3-N3 (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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E3 Ligase Ligand-linker Conjugate 55
0 ImagesCat. No.: HY-162205E3 Ligase Ligand-linker Conjugate 55 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker Conjugate 55 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
