E3 Ligase Ligand-Linker Conjugates
E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc. MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.
E3 Ligase Ligand-Linker Conjugates Isoform Specific Products
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E3 Ligase Ligand-Linker Conjugates Related Products (1117)
Related Products (1117)
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Antibodies (1)
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E3 Ligase Ligand-Linker Conjugates Isoform Comparison
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Pomalidomide-C7-NH2
0 ImagesCat. No.: HY-155560CAS No.: 2093387-55-2Synonyms: Pomalidomide 4'-alkylC7-aminePomalidomide-C7-NH2 (Pomalidomide 4'-alkylC7-amine) (Compound 24g) is an E3 Ligase Ligand-Linker Conjugates consisting of Pomalidomide (HY-10984) and a linker. Pomalidomide-C7-NH2 can be used for synthesis of PROTACs.
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Pomalidomide-C6-NHS ester
0 ImagesCat. No.: HY-148143CAS No.: 2828476-88-4Pomalidomide-C6-NHS ester is a synthesized E3 ligase ligand-linker conjugate, incorporating the Pomalidomide based cereblon ligand and NHS ester linker.
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Thalidomide-piperidine-C-2,6-diazaspiro[3.3]heptane-C2-OH
![Thalidomide-piperidine-C-2,6-diazaspiro[3.3]heptane-C2-OH](https://file.medchemexpress.com/product_pic/hy-161190.gif "Click to View Thalidomide-piperidine-C-2,6-diazaspiro[3.3]heptane-C2-OH Product Detail")
0 ImagesCat. No.: HY-161190Thalidomide-piperidine-C-2,6-diazaspiro[3.3]heptane-C2-OH is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-piperidine-C-2,6-diazaspiro[3.3]heptane-C2-OH can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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Pomalidomide-5-C10-NH2 hydrochloride
0 ImagesCat. No.: HY-155266CAS No.: 2863635-00-9
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Thalidomide-4-O-C5-NH2
0 ImagesCat. No.: HY-138848CAS No.: 2307477-23-0Thalidomide-4-O-C5-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
![(S)-Deoxy-thalidomide-2,7-diazaspiro[3.5]nonane-C-Pip](https://file.medchemexpress.com/product_pic/hy-168310.gif "Click to View (S)-Deoxy-thalidomide-2,7-diazaspiro[3.5]nonane-C-Pip Product Detail")
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Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc
0 ImagesThalidomide-O-amido-CH2-PEG3-CH2-NH-Boc is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc incorporates the Thalidomide based cereblon ligand and a linker. Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc can be used for the synthesis of PROTAC BET degrader. (From patent WO2017180417A1 compound s7).
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Dione-piperidine-indazol-piperazin-cyclohexyl-NH2
0 ImagesCat. No.: HY-174797CAS No.: 3052791-98-4Dione-piperidine-indazol-piperazin-cyclohexyl-NH2 is an E3 ligase ligand-linker conjugate that incorporates a CRBN ligand (HY-W883326) and linker. Dione-piperidine-indazol-piperazin-cyclohexyl-NH2 can be used for synthesis of PROTAC MD-4251 (HY-174458).
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(R,S,S)-VH032-Me-N-Boc-7-aminoheptanoic acid TFA
0 ImagesCat. No.: HY-173628B(R,S,S)-VH032-Me-N-Boc-7-aminoheptanoic acid TFA is a conjugate of an E3 ubiquitin ligase ligand (HY-112078) and a linker (HY-W012001). (R,S,S)-VH032-Me-N-Boc-7-aminoheptanoic acid TFA can be used as an intermediate in the synthesis of dTAGV-1 hydrochloride (HY-145514C).
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E3 Ligase Ligand-linker Conjugate 45
0 ImagesCat. No.: HY-162199CAS No.: 2871775-00-5E3 Ligase Ligand-linker Conjugate 45 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker Conjugate 45 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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E3 ligase Ligand-Linker Conjugate 29
0 ImagesCat. No.: HY-157587E3 ligase Ligand-Linker Conjugate 29 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase Ligand-Linker Conjugate 29 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
