HMG-CoA Reductase (HMGCR)
HMG-CoA Reductase (HMGCR) is the rate-limiting enzyme for cholesterol synthesis in the conversion of HMG-CoA to mevalonate. HMGCR is found in eukaryotes and prokaryotes. The phylogenetic analysis has revealed two classes of HMG-CoA reductase, the Class I enzymes of eukaryotes and some archaea and the Class II enzymes of eubacteria and certain other archaea.
Both in eukaryotes and in archaebacteria the enzyme HMGCR is known to catalyze an early reaction unique to isoprenoid biosynthesis. In humans, the HMG-CoA reductase reaction is rate-limiting for the biosynthesis of cholesterol and therefore constitutes a prime target of drugs that reduce serum cholesterol levels.
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HMG-CoA Reductase (HMGCR) Related Products (168)
Related Products (168)
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Antibodies (13)
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Bemfivastatin hemicalcium
0 ImagesSynonyms: PPD 10558 hemicalciumBemfivastatin (PPD 10558) hemicalcium is an orally active HMG-CoA Reductase (HMGCR) inhibitor. Bemfivastatin hemicalcium enhances the activity of liver extraction and reduces blood lipid levels. Bemfivastatin hemicalcium can be used for research of metabolic disease, such as hypercholesterolemia.
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Lovastatin acid
0 ImagesCat. No.: HY-122439CAS No.: 75225-51-3Synonyms: Mevinolinic acid; MSD803Lovastatin acid (Mevinolinic acid; MSD803), an active metabolite of Lovastatin (HY-N0504), is a potent competitive HMG-CoA reductase inhibitor with a Ki of 0.6 nM. Lovastatin acid acts as a competitive inhibitor with respect to substrate HMG-CoA, interfering cholesterol synthesis. Lovastatin acid can be used for the research of hypercholesterolemia.
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(3S,5S)-Pitavastatin calcium
0 Images(3S,5S)-Pitavastatin calcium is the 3-epimer of Pitavastatin Calcium (HY-B0144). Pitavastatin Calcium is a potent HMG-CoA reductase inhibitor that can be used for the study of cardiovascular disease.
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HMGCR Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS06238HMGCR Human Pre-designed siRNA Set A contains three designed siRNAs for HMGCR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Apomine
0 ImagesSynonyms: SR-45023A; SR 9223i; SK&F-99085Apomine (SR-45023A) is an orally active antineoplastic agent that inhibits the mevalonate/isoprenoid pathway in cholesterol synthesis. Apomine can accelerate the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR). Apomine can also inhibit the growth of various types of cancer cells, including lung cancer, colon cancer, breast cancer, and skin cancer. Apomine is able to induce apoptosis in tumor cell lines derived from leukemia, colon cancer, liver cancer, ovarian cancer, and breast cancer.
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(3S,5R)-Fluvastatin sodium
0 ImagesSynonyms: (3S,5R)-XU 62-320(3S,5R)-Fluvastatin sodium ((3S,5R)-XU 62-320) is the (3S,5R)-enantiomer of Fluvastatin. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway.
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N-Desmethyl rosuvastatin disodium hydrate
0 ImagesCat. No.: HY-W740010N-Desmethyl rosuvastatin disodium hydrate is an active metabolite of HMG-CoA reductase (HMGCR) inhibitor rosuvastatin (HY-17504). N-Desmethyl rosuvastatin disodium hydrate can be utilized in research of rosuvastatin metabolism.
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Rosuvastatin-d6 calcium
0 ImagesCat. No.: HY-17504SRosuvastatin-d6 calcium is the deuterated-labeled Rosuvastatin Calcium (HY-17504). Rosuvastatin Calcium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Calcium potently blocks hERG current with an IC50 of 195 nM. Rosuvastatin Calcium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Calcium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.
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Mevastatin (Standard)
0 ImagesSynonyms: Compactin(Standard); ML236B (Standard)Mevastatin (Standard) is the analytical standard of Mevastatin. This product is intended for research and analytical applications. Mevastatin (Compactin) is a first HMG-CoA reductase inhibitor that belongs to the statins class. Mevastatin is a lipid-lowering agent, and induces apoptosis, arrests cancer cells in G0/G1 phase. Mevastatin also increases endothelial nitric oxide synthase (eNOS) mRNA and protein levels. Mevastatin has antitumor activity and has the potential for cardiovascular diseases treatment.
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(3R,5S)-Fluvastatin sodium
0 ImagesSynonyms: (3R,5S)-XU 62-320(3R,5S)-Fluvastatin ((3R,5S)-XU 62-320) sodium is the 3R,5S-isomer Fluvastatin. Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway.
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Fluvastatin sodium (Standard)
0 ImagesSynonyms: XU 62-320 (Standard)Fluvastatin (sodium) (Standard) is the analytical standard of Fluvastatin (sodium). This product is intended for research and analytical applications. Fluvastatin sodium (XU 62320) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin sodium protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway.
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Ganoderenic acid K
0 ImagesGanoderenic acid K is a natural product, that can be isolated from fruiting bodies of Ganoderma lucidum. Ganoderenic acid K shows strong inhibitory activity against HMG-CoA reductase (HMGCR) with IC50 of 16.5 μM.
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Pravastatin-d3 sodium
0 ImagesCat. No.: HY-B0165CSCAS No.: 1329836-90-9Pravastatin-d3 (sodium) is the deuterium labeled Pravastatin sodium salt. Pravastatin (CS-514) sodium salt is a competitive HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.
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(Rac)-3′-Hydroxy simvastatin
0 ImagesCat. No.: HY-136345CAS No.: 126313-98-2(Rac)-3′-Hydroxy simvastatin is an isomer of 3′-Hydroxy simvastatin. 3′-Hydroxy simvastatin is an oxidative metabolite of Simvastatin (HY-17502) produced by hepatic CYP450 metabolism, and is also the major terminal metabolite of Simvastatin in rats. 3′-Hydroxy simvastatin possesses HMG-CoA Reductase inhibitory activity. 3′-Hydroxy simvastatin is used in metabolism-related research.
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(3S,5R)-Pitavastatin calcium
0 Images(3S,5R)-Pitavastatin calcium is the enantiomer of Pitavastatin Calcium (HY-B0144). Pitavastatin is a potent HMG-CoA reductase inhibitor.
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Rosuvastatin-13C,d3 sodium
0 ImagesCat. No.: HY-17504BS2Purity: 98.31%Synonyms: ZD 4522-13C,d3 sodium; X-Plended-13C,d3 sodium; Crestor-13C,d3 sodiumRosuvastatin-13C,d3 sodium is 13C and deuterated labeled Rosuvastatin sodium (HY-17504B). Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC50 of 195 nM. Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.
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Ethyl trans-caffeate
0 ImagesEthyl trans-caffeate is a matrix metalloproteinase inhibitor (MMP-1, MMP-2, MMP-9). Ethyl trans-caffeate can be isolated from Artemisia aucheri. Ethyl trans-caffeate binds to the SARS-CoV-2 main protease by forming a hydrogen bond with Thr190. The PMK extract of Pandanus tectorius fruit containing Ethyl trans-caffeate inhibits HMG-CoA reductase activity. Ethyl trans-caffeate can be used in research on COVID-19 and atherosclerosis.
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Pravastatin
0 ImagesCat. No.: HY-B0165CAS No.: 81093-37-0Synonyms: CS-514Pravastatin (CS-514) is a competitive HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.
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Rosuvastatin (Standard)
0 ImagesCat. No.: HY-17504ARCAS No.: 287714-41-4Synonyms: ZD 4522 (Standard)Rosuvastatin (Standard) is the analytical standard of Rosuvastatin (HY-17504A). This product is intended for research and analytical applications. Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM. Rosuvastatin potently blocks hERG current with an IC50 of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.
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Fluvastatin sodium monohydrate
0 ImagesCat. No.: HY-14664DCAS No.: 201541-53-9Synonyms: XU 62-320 monohydrateFluvastatin (XU 62-320) sodium monohydrate is a first fully synthetic, competitive HMG-CoA reductaseinhibitor with an IC50 of 8 nM. Fluvastatin (sodium monohydrate) protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway.
