HMG-CoA Reductase (HMGCR)
HMG-CoA Reductase (HMGCR) is the rate-limiting enzyme for cholesterol synthesis in the conversion of HMG-CoA to mevalonate. HMGCR is found in eukaryotes and prokaryotes. The phylogenetic analysis has revealed two classes of HMG-CoA reductase, the Class I enzymes of eukaryotes and some archaea and the Class II enzymes of eubacteria and certain other archaea.
Both in eukaryotes and in archaebacteria the enzyme HMGCR is known to catalyze an early reaction unique to isoprenoid biosynthesis. In humans, the HMG-CoA reductase reaction is rate-limiting for the biosynthesis of cholesterol and therefore constitutes a prime target of drugs that reduce serum cholesterol levels.
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HMG-CoA Reductase (HMGCR) Related Products (168)
Related Products (168)
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Antibodies (13)
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Pitavastatin sodium
0 ImagesCat. No.: HY-B0144BCAS No.: 574705-92-3Synonyms: NK-104 sodiumPitavastatin (NK-104) sodium is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin sodium inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin sodium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin sodium also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects.
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Rosuvastatin zinc salt
0 ImagesCat. No.: HY-108774CAS No.: 953412-08-3Synonyms: Rosuvastatin zincRosuvastatin zinc salt (Rosuvastatin zinc) is a zinc-containing form of Rosuvastatin (HY-17504A). Rosuvastatin is a HMG-CoA reductase inhibitor and can be used for atherosclerosis research.
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PROTAC HMGCR Degrader-1
0 ImagesCat. No.: HY-171823CAS No.: 2715104-45-1PROTAC HMGCR Degrader-1 is an orally active HMGCR PROTAC degrader with IC50 of 1.32 μM. PROTAC HMGCR Degrader-1 is a lactone prodrug of PROTAC HMGCR Degrader-2 (HY-181134). PROTAC HMGCR Degrader-1 achieves high plasma exposure of the active ingredient leading to robust HMGCR degradation and demonstrating promising cholesterol-lowering efficacy in vivo. PROTAC HMGCR Degrader-1 can be used for hyperlipidemia research.
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Simvastatin acid calcium hydrate
0 ImagesCat. No.: HY-119695BCAS No.: 530112-57-3Synonyms: Tenivastatin calcium hydrateSimvastatin acid (Tenivastatin) calcium hydrate is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid calcium hydrate reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid calcium hydrate can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene.
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Pravastatin-d9 sodium
0 ImagesCat. No.: HY-B0165SSynonyms: CS-514-d9 sodiumPravastatin-d9 sodium is deuterated labeled Pravastatin (HY-B0165). Pravastatin (CS-514) is a competitive HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.
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S-2E
0 ImagesCat. No.: HY-139134CAS No.: 155730-92-0S-2E is an orally active and noncompetitive HMG-CoA reductase and acetyl-CoA carboxylase inhibitor. S-2E has an anti-hyperlipidemic action. S-2E has the potential for familial hypercholesterolemia and mixed hyperlipidemia research.
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Simvastatin hydroxy acid-d6sodium
0 ImagesCat. No.: HY-115292SCAS No.: 2747915-76-8Synonyms: Tenivastatin-d6 sodium; Simvastatin impurity A-d6 sodiumSimvastatin hydroxy acid-d6 sodium (Tenivastatin-d6 sodium) is the deuterium labeled Simvastatin hydroxy acid sodium (HY-115292). Simvastatin hydroxy acid (Tenivastatin) sodium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin hydroxy acid sodium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin hydroxy acid sodium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene.
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Atorvastatin (lysine)
0 ImagesCat. No.: HY-182257CAS No.: 609843-23-4Atorvastatin lysine is an inhibitor of HMG-CoA reductase. Atorvastatin lysine can be used to study hypercholesterolemia and mixed hyperlipidemia.
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Pitavastatin-d4-1 sodium
0 ImagesCat. No.: HY-B0144AS3Purity: 99.22%Synonyms: NK-104-d4-1 sodiumPitavastatin-d4-1 (NK-104-d4-1) sodium is the deuterium labeled Pitavastatin sodium (HY-B0144B). Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects.
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4-Acetylsimvastatin (Standard)
0 ImagesCat. No.: HY-135405RCAS No.: 145576-25-64-Acetylsimvastatin (Standard) is the analytical standard of 4-Acetylsimvastatin. This product is intended for research and analytical applications. 4-Acetylsimvastatin is an acetylated simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM.
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(3S,5R)-Fluvastatin potassium
0 ImagesCat. No.: HY-137390ACAS No.: 1009811-63-5(3S,5R)-Fluvastatin (potassium) is a synthetic hypolipidemic drug that inhibits HMG-CoA reductase activity. (3S,5R)-Fluvastatin (potassium) has similar antioxidative effects on copper ion-induced LDL oxidation compared to its 3R,5S enantiomer. (3S,5R)-Fluvastatin (potassium) and its metabolites demonstrate a potential to exhibit anti-atherosclerotic effects through their antioxidative activities. (3S,5R)-Fluvastatin (potassium) is clinically utilized as part of a racemic mixture for reducing plasma cholesterol levels.
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L-157012
0 ImagesCat. No.: HY-116241CAS No.: 114801-28-4L-157012 is a HMG-CoA reductase (HMGCR) inhibitor. L-157012 is also a cholesterol-lowering agent.
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NO-Pravastatin
0 ImagesCat. No.: HY-184354CAS No.: 733034-46-3NO-Pravastatin is a derivative of Pravastatin (HY-B0165) covalently linked with an NO donor moiety, endowing it with dual functions of HMG-CoA reductase (HMGCR) inhibition and exogenous nitric oxide (NO) release. NO-Pravastatin activates PPARα/γ and ABCA1, and inhibits LPS (HY-D1056)-induced TNFα production. NO-Pravastatin can be used in research related to gallstones and cardiovascular diseases.
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Rosuvastatin-d3
0 ImagesCat. No.: HY-17504ASCAS No.: 1133429-16-9Synonyms: ZD 4522 d3Rosuvastatin-d3 is the deuterated-labeled Rosuvastatin (HY-17504A). Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM. Rosuvastatin potently blocks hERG current with an IC50 of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.
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BMS-180431
0 ImagesCat. No.: HY-19077CAS No.: 129829-03-4BMS-180431 is an inhibitor of HMG-CoA reductase (IC50: 43 nM).
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Ganoderic acid SZ
0 ImagesCat. No.: HY-129149CAS No.: 865543-37-9Ganoderic acid SZ is a natural product with 3-hydroxy-3-methylglutaryl-CoA reductase inhibitory activity. Ganoderic acid SZ shows stronger activity than the positive control atorvastatin in inhibiting HMG-CoA reductase. Ganoderic acid SZ exhibits significant inhibition of yeast-derived α-glucosidase with IC50 values achieved at very low concentrations. Ganoderic acid SZ also exhibits cytotoxicity against K562 cells with IC?? values in the range of 10-20 μM.
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Dim16
0 ImagesCat. No.: HY-149310CAS No.: 2743448-32-8Dim16 is a dual PCSK9 inhibitor and HMG-CoAR inhibitor, with an IC50 of 0.8 nM against human PCSK9 and an IC50 of 146.8 μM against HMG-CoAR. Dim16 disrupts the PCSK9-LDLR protein-protein interaction, inhibits the catalytic activity of HMG-CoAR, enhances cellular uptake of extracellular LDL, and suppresses PCSK9-induced platelet aggregation. Dim16 can be used in research related to hypercholesterolemia.
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Ganomycin I
0 ImagesCat. No.: HY-N10076CAS No.: 1191255-15-8Ganomycin I is a non-competitive dual inhibitor of α-glucosidase and HMG-CoA reductase, with IC50 values of 0.3 μM and 12.3 μM, respectively. Ganomycin I inhibits HIV-1 protease, with an IC50 of 7.5 μg/mL. Ganomycin I also suppresses RANKL-induced osteoclast differentiation and bone resorption by inhibiting the activation of ERK, JNK and p38 MAPK, as well as downregulating the c-Fos/NFATc1 signaling pathway. Ganomycin I exhibits antibacterial activity against Gram-positive bacteria, and shows weak activity against Mycobacterium tuberculosis H37Ra. It can be used in research related to metabolic diseases, bone metabolism and anti-infection.
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Atorvastatin lactone-d5
0 ImagesCat. No.: HY-101873SAtorvastatin lactone-d5 is the d5-labeled Atorvastatin lactone (HY-101873). Atorvastatin lactone is a metabolite of Atorvastatin acid, an HMG-CoA reductase inhibitor. Atorvastatin lactone exhibits myotoxicity.
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Hmgcr Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS06239Hmgcr Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hmgcr gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
