Influenza Virus
Influenza virus belongs to the Orthomyxoviridae group, which are enveloped, segmented, single-stranded negative sense RNA viruses. The group includes three types of influenza viruses, A, B and C. Type B and C viruses only infect humans, but the type A viruses infect humans, horses, swine, other mammals, and a wide variety of domesticated and wild birds. Human influenza A and B viruses cause seasonal epidemics of disease almost every winter in the United States. The emergence of a new and very different influenza virus to infect people can cause an influenza pandemic. Influenza type C infections cause a mild respiratory illness and are not thought to cause epidemics. Each virus subtype has mutated into a variety of strains with differing pathogenic profiles; some are pathogenic to one species but not others, some are pathogenic to multiple species.
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Influenza Virus Related Products (728)
Related Products (728)
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Recombinant Proteins (585)
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Antibodies (1)
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SCH-202676
0 ImagesSCH-202676 is an allosteric modulator of G protein-coupled receptors (GPCRs) and adenosine receptor (AR). SCH-202676 has antiviral activity and inhibits 3CLpro in a time-dependent manner with an IC50 value of 0.655 µM.
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Neuraminidase-IN-11
0 ImagesCat. No.: HY-151104CAS No.: 2685786-28-9Neuraminidase-IN-11 (15e) is a potent and selective neuraminidase (NA) inhibitor with the IC50 values of 4.7 nM, 8.46 nM and 1.5 nM against H1N1, H5N1 and H5N8 NAs respectively.
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PROTAC Hemagglutinin Degrader-1
0 ImagesCat. No.: HY-147654CAS No.: 3031330-66-9PROTAC Hemagglutinin Degrader-1 (Compound V3) is a potent PROTAC influenza hemagglutinin (HA) degrader with a median degradation concentration of 1.44 μM. PROTAC Hemagglutinin Degrader-1 shows broad-spectrum anti-influenza virus activity.
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Wulignan A1
0 ImagesWulignan A1 is isolated from the stems of Schisandra henryi. Wulignan A1 exhibits anti-influenza virus H1N1 and H1N1-TR (a Tamiflu agent resistant virus strain) activities.
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Tizoxanide (Standard)
0 ImagesCat. No.: HY-12687RCAS No.: 173903-47-4Synonyms: TIZ (Standard)Tizoxanide (Standard) is the analytical standard of Tizoxanide. This product is intended for research and analytical applications. Tizoxanide (TIZ) is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide (TIZ) has anti-HIV-1 activities and potent inhibition of both HBV and HCV replication with values EC50 of 0.46μM and 0.15 μM, respectively. Tizoxanide also exerts anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines and suppressing of the activation of the NF-κB and the MAPK signaling pathways in LPS-treated macrophage cells.
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Influenza A virus-IN-14
0 ImagesCat. No.: HY-162492CAS No.: 3050773-93-5Influenza A virus-IN-14 (Compound 37) is an inhibitor for influenza virus type A (IAV), which inhibits H1N1 with an EC50 of 23 nM. Influenza A virus-IN-14 exhibits low cytotoxicity with CC50 of more than 100 μM. Influenza A virus-IN-14 inhibits cytopathic effect and improves the survival rates of cell Calu3. Influenza A virus-IN-14 exhibits synergistic activity with the neuraminidase inhibitor Oseltamivir (HY-13317). Influenza A virus-IN-14 exhibits poor pharmacokinetic properties in CD-1 mouse.
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Antiviral agent 35
0 ImagesCat. No.: HY-155731CAS No.: 2760972-52-7Antiviral agent 35 (compound 4d) is an orally active and potent influenza virus inhibitor, acting function in the early stage of virus replication. Antiviral agent 35 inhibits ROS accumulation, autophagy and apoptosis induced by influenza virus, and also inhibits inflammatory response mediated by RIG-1 pathway in mouse model with pulmonary infection. Antiviral agent 35 shows little cytotoxicity with CC50 >800 μM in MDCK cells, and anti-H1N1 (A/Weiss/43) activity with EC50 of 2.28 μM.
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Cap-dependent endonuclease-IN-22
0 ImagesCat. No.: HY-143776CAS No.: 2641942-32-5Cap-dependent endonuclease-IN-22 is a potent cap-dependent endonuclease (CEN) inhibitor.
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N-Acetylneuraminic acid-13C-2
0 ImagesCat. No.: HY-I0400S2CAS No.: 220803-19-0Synonyms: NANA-13C-2; Lactaminic acid-13C-2N-Acetylneuraminic acid-13C-2 is the 13C labeled N-Acetylneuraminic acid.
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Influenza A virus-IN-18
0 ImagesCat. No.: HY-181785CAS No.: 3085746-63-7Influenza A virus-IN-18 (Compound C2e) is an orally active inhibitor of Influenza A virus (IC50: 2.5 μM against PR8/H1N1; 6.42 μM against H3N2). Influenza A virus-IN-18 binds directly to the H1N1/PR8 HA protein with high affinity, with a KD of 0.25 μM. Influenza A virus-IN-18 is applicable to research related to Influenza A virus infection.
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5-Hydroxy-6,7-dimethoxyflavone
0 Images5-Hydroxy-6,7-dimethoxyflavone is an orally active inhibitor of ferroptosis (Ferroptosis). 5-Hydroxy-6,7-dimethoxyflavone inhibits H1N1 virus-induced ferroptosis by upregulating the expression of SLC7A11 and GPX4. 5-Hydroxy-6,7-dimethoxyflavone alleviates inflammatory responses and inhibits apoptosis by suppressing the activation of the NF-κB and p38 MAPK signaling pathways. 5-Hydroxy-6,7-dimethoxyflavone can be used in studies related to H1N1 influenza virus infection.
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Laninamivir octanoate hydrate
0 ImagesCat. No.: HY-14818CCAS No.: 1233643-88-3Synonyms: CS-8958 hydrateLaninamivir octanoate hydrate (CS-8958 hydrate), a prodrug of Laninamivir, is a long-acting neuraminidase (NA) inhibitor with anti-influenza virus activity. Laninamivir octanoate hydrate shows anti-influenza activity against Oseltamivir-resistant viruses, and also against the pandemic influenza viruses.
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Anti-Influenza agent 9
0 ImagesCat. No.: HY-179482Anti-Influenza agent 9 (Compound 3p) is a M2-S31N mutant influenza virus ion channel blocker. Anti-Influenza agent 9 exhibits inhibitory activity against both M2-WT and M2-S31N viruses, with its EC50 values being 0.92 and 0.55 μM respectively. Anti-Influenza agent 9 can be used in influenza research.
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JAK2-IN-20
0 ImagesCat. No.: HY-181691JAK2-IN-20 is an orally active dual inhibitor targeting JAK2 kinase (IC50=49.17 nM) and influenza A virus PB2 protein (IC50=3.337 μM, Kd=2.82 μM). JAK2-IN-20 effectively blocks the JAK/STAT signaling pathway by reducing the phosphorylation levels of STAT1 and STAT3, thereby inhibiting viral replication and downregulating the expression of viral NP and PB2 proteins. In addition, JAK2-IN-20 significantly inhibits the mRNA expression of key inflammatory cytokines such as IL-6, TNF-α and IFN-β in inflammation and influenza infection models. JAK2-IN-20 serves as an important tool molecule for the study of influenza A virus infection and related pathologies.
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(+)-Aureol
0 ImagesCat. No.: HY-N20663CAS No.: 72853-81-7(+)-Aureol is a tetracyclic benzopyran-fused decalin-type 9-norspongiane heteroterpenoid. (+)-Aureol exhibits antifungal activity, with an EC50 value of 6.9 μM against Rhizoctonia solani and an EC50 value of 19 μM against Sclerotinia sclerotiorum. (+)-Aureol shows selective inhibitory activity against human tumor cells. (+)-Aureol acts as an anti-influenza agent with activity against influenza A virus. (+)-Aureol can be used in research related to fungal infections, non-small cell lung cancer, colon adenocarcinoma and influenza A virus infections.
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Yadanziolide B
0 ImagesCat. No.: HY-N8399CAS No.: 95258-13-2Yadanziolide B, a natural quassinoid, is a potential H5N1 neuraminidase inhibitor.
