PPAR Agonist
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PPARα agonist 6
0 ImagesPPARα agonist 6 (Compound 15) is a PPARα agonist. PPARα agonist 6 can be used in the research of dyslipidemia.
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Rosiglitazone-d4
0 ImagesCat. No.: HY-17386S1CAS No.: 1132641-21-4Synonyms: BRL 49653-d4Rosiglitazone-d4 is deuterated labeled Rosiglitazone (HY-17386). Rosiglitazone (BRL 49653) is an orally active selective PPARγ agonist (EC50: 60 nM, Kd: 40 nM). Rosiglitazone is an TRPC5 activator (EC50: 30 μM) and TRPM3 inhibitor. Rosiglitazone can be used in the research of obesity and diabetes, senescence, ovarian cancer.
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Oleoylethanolamide-d4
0 ImagesCat. No.: HY-107542SCAS No.: 946524-36-3Synonyms: N-Oleoylethanolamide-d4; Oleamide MEA-d4; Oleic acid monoethanolamide-d4Oleoylethanolamide-d4 is the deuterium labeled Oleoylethanolamide. Oleoylethanolamide is a high affinity endogenous PPAR-α agonist, which plays an important role in the treatment of obesity and arteriosclerosis.
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RG-12525
0 ImagesSynonyms: NID 525RG-12525 is a a specific, competitive and orally effective antagonist of the peptidoleukotrienes, LTC4, LTD4 and LTE4, inhibiting LTC4-, LTD4- and LTE4-inducd guinea pig parenchymal strips contractions, with IC50s of 2.6 nM, 2.5 nM and 7 nM, respectively; RG-12525 is also a peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist with IC50 of appr 60 nM and a potent inhibitor of CYP3A4, with a Ki value of 0.5 µM.
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Icosabutate
0 ImagesCat. No.: HY-121212CAS No.: 1253909-57-7Icosabutate is an orally active engineered fatty acid and a dual FFAR1/FFAR4 (GPR40/GPR120) agonist with EC50 values of 10 μM and 15.5 μM, respectively. Icosabutate acts as a partial agonist of PPAR-α, with an EC50 of 208 nM. Icosabutate inhibits the arachidonic acid cascade and exhibits antioxidant and anti-apoptotic activities. Icosabutate can be used in the research of nonalcoholic steatohepatitis, metabolic dysfunction-associated steatohepatitis, and atherosclerosis.
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Wistin
0 ImagesCat. No.: HY-N9333CAS No.: 19046-26-5
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Amorfrutin B
0 ImagesCat. No.: HY-113631CAS No.: 78916-42-4Amorfrutin B is a highly potent natural peroxisome proliferation-activated receptor γ (PPARγ) agonist with oral activity with Ki values of 19 nM and EC50 values of 73 nM, respectively. Amorfrutin B has hypoglycemic and neuroprotective activities.
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Eupatilin (Standard)
0 ImagesEupatilin (Standard) is the analytical standard of Eupatilin. This product is intended for research and analytical applications. Eupatilin, a lipophilic flavonoid isolated from Artemisia argyi Lévl. et Van., is a PPARα agonist, and possesses anti-apoptotic, anti-oxidative and anti-inflammatory activities.
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Candesartan (Standard)
0 ImagesSynonyms: CV 11974 (Standard)Candesartan (Standard) is the analytical standard of Candesartan. This product is intended for research and analytical applications. Candesartan (CV 11974) is an orally active angiotensin II AT1-Receptor blocker and PPAR-γ agonist. Candesartan has potent and long-lasting antihypertensive effects. Candesartan can be used for the research of hypertension, chronic heart failure (CHF) and Traumatic brain injury (TBI).
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Naveglitazar
0 ImagesSynonyms: LY519818Naveglitazar (LY519818) is a nonthiozolidinedione peroxisome proliferator-activated receptor (PPAR) α-γ dual, γ-dominant agonist that has shown glucose-lowering potential in animal models.
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Rosiglitazone-d3
0 ImagesCat. No.: HY-17386SCAS No.: 1132641-22-5Rosiglitazone-d3 is the deuterium labeled Rosiglitazone. Rosiglitazone (BRL 49653) is a selective, orally active PPARγ agonist with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively. Rosiglitazone binds to PPARγ with a Kd of approximately 40 nM. Rosiglitazone is also an activator of TRPC5 (EC50=~30 μM) and an inhibitor of TRPM3.
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PPARγ agonist 11
0 ImagesCat. No.: HY-116468CAS No.: 1143573-33-4PPARγ agonist 11 (compound 20) is a selective agonist of PPARγ (EC50: 0.1 μM).
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GSK376501A
0 ImagesGSK376501A is a selective peroxisome proliferator-activated receptor gamma (PPARγ) modulator for the treatment of type 2 diabetes mellitus.
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PPAR agonist 1
0 ImagesPPAR agonist 1 is an agonist of PPAR α and PPAR γ, used for reducing blood glucose, lipid levels, lowering cholesterol and reducing body weight.
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Chiglitazar sodium
0 ImagesSynonyms: Carfloglitazar sodium
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Tibric acid
0 ImagesCat. No.: HY-121755CAS No.: 37087-94-8Synonyms: CP 18524Tibric acid (CP 18524) has similar effects to those of hypolipidemic agents. Tibric acid has orally active triglyceride-lowering effects. Tibric acid can be used for research of hypertriglyceridemia.
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Raspberry ketone (Standard)
0 ImagesSynonyms: Frambione (Standard); 4-(4-Hydroxyphenyl)-2-butanone (Standard)Raspberry ketone (Standard) is the analytical standard of Raspberry ketone. This product is intended for research and analytical applications. Raspberry ketone is a major aromatic compound of red raspberry, widely used as a fragrance in cosmetics and as a flavoring agent in foodstuff; also shows PPAR-α agonistic activity.
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Seladelpar (lysine)
0 ImagesSynonyms: MBX-8025 (lysine); RWJ-800025 (lysine)Seladelpar (MBX-8025) lysine is an orally active, potent and specific PPARδ agonist with an EC50 of 2 nM. Seladelpar lysine shows more than 750-fold and 2500-fold selectivity over the PPARα and PPARγ receptors, respectively. Seladelpar lysine can be used for the study of primary biliary cholangitis.
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GW 501516 (Standard)
0 ImagesSynonyms: GW 1516 (Standard); GSK-516 (Standard)GW 501516 (Standard) is the analytical standard of GW 501516. This product is intended for research and analytical applications. GW 501516 (GW 1516) is a PPARδ agonist with an EC50 of 1.1 nM.
