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- Membrane Transporter/Ion Channel
- Potassium Channel
Potassium Channel
KcsA
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Potassium Channel Inhibitors
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Potassium Channel 관련 제품 (1155)
관련 제품 (1155)
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Antibodies (6)
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Related Compound Screening Libraries (1)
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L-Palmitoylcarnitine-d9
0 ImagesL-Palmitoylcarnitine-d9 is deuterium labeled L-Palmitoylcarnitine. L-Palmitoylcarnitine, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2. -
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Amsacrine lactate
0 ImagesCat. No.: HY-13551DCAS No.: 80277-11-8Synonyms: m-AMSA lactate; Acridinyl anisidide lactateAmsacrine lactate (m-AMSA lactate) is a Topoisomerase II inhibitor. Amsacrine lactate intercalates into DNA. Amsacrine lactate induces Ca2+-mediated inactivation of ERK, and also downregulates AKT, promoting MCL1 downregulation mediated by GSK3β via reducing the phosphorylation level of GSK3β. Amsacrine lactate induces Apoptosis by activating Caspase-9 and Caspase-3. Amsacrine lactate blocks HERG potassium channels in the open/inactivated state. Amsacrine lactate induces chromosomal aberrations and sister chromatid exchanges, and inhibits the synthesis of RNA and DNA. Amsacrine lactate exhibits anti-leukemic activity. Amsacrine lactate causes cardiac repolarization disorders, QT interval prolongation, ventricular arrhythmias, and increases the risk of sudden cardiac death. Amsacrine lactate can be used in research related to acute myeloid leukemia, lymphoma and progressive malignancies. -
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BL-1249 (Standard)
0 ImagesCat. No.: HY-108596RCAS No.: 18200-13-0BL-1249 (Standard) is the analytical standard of BL-1249 (HY-108596). This product is intended for research and analytical applications. BL-1249 is a nonsteroidal anti-inflammatory agent (NSAID) and a potassium channel activator. BL-1249 potently activates K2P2.1 (TREK-1) and K2P10.1 (TREK-2) with EC50 values of 5.5 μM and 8.0 μM, respectively. BL-1249 extracellular application activates all TREK subfamily members but has no effect on other K2P subfamilies. BL-1249 exhibits more selective for the bladder (EC50 of 1.26 μM) than vascular tissue (EC50 of 21.0 μM). -
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Quindecamine
0 ImagesCat. No.: HY-Z13814CAS No.: 19056-26-9Quindecamine (UCL 1407) is a potent IKCa blocker with anIC50 of 0.85 μM. -
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Nifekalant hydrochloride (Standard)
0 ImagesCat. No.: HY-B0772ARCAS No.: 130656-51-8Synonyms: MS-551 (Standard)Nifekalant (hydrochloride) (Standard) is the analytical standard of Nifekalant (hydrochloride). This product is intended for research and analytical applications. Nifekalant hydrochloride (MS-551), a class III antiarrhythmic agent, is a IKr potassium channel blocker with an IC50 of 10 µM. Nifekalant hydrochloride can be used for refractory ventricular tachyarrhythmias research. -
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Sematilide hydrochloride (Standard)
0 ImagesSynonyms: CK-1752 hydrochloride (Standard)Sematilide (hydrochloride) (Standard) is the analytical standard of Sematilide (hydrochloride). This product is intended for research and analytical applications. Sematilide hydrochloride (CK-1752 hydrochloride) is a selective IKr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM). Sematilide is a class III antiarrhythmic agent. -
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PNU-140975
0 ImagesCat. No.: HY-114690CAS No.: 179474-69-2Synonyms: BVT.3531PNU-140975 (BVT.3531) is a novel and potent bioactive compound. PNU-140975 can reduce body weight and activates KATP channel in isolated arcuate neurons in rats. -
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Flecainide-d3
0 ImagesFlecainide-d3 is the deuterium labeled Flecainide. Flecainide is an orally active antiarrhythmic agent. Flecainide can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT). -
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Senicapoc (Standard)
0 ImagesSynonyms: ICA-17043 (Standard)Senicapoc (Standard) is the analytical standard of Senicapoc. This product is intended for research and analytical applications. Senicapoc (ICA-17043) is a potent and selective Gardos channel (Ca2+-activated K+ channel; KCa3.1) blocker with an IC50 of 11 nM. Senicapoc blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 nM and inhibits RBC dehydration with IC50 of 30 nM. -
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Daurisoline-d5
0 ImagesCat. No.: HY-N0221S1Synonyms: (R,R)-Daurisoline-d5Daurisoline-d5 is the deuterium labeled Daurisoline (HY-N0221). Daurisoline is a bis-benzylisoquinoline alkaloid that can be isolated from Menispermum dauricum and Rhizoma Menispermi. Daurisoline exerts a blocking effect on hERG and has antiarrhythmic effects. Daurisoline is a potent autophagy blocker that can be used for the research of cancer. -
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Mefloquine hydrochloride (Standard)
0 ImagesSynonyms: Mefloquin hydrochloride (Standard)Mefloquine (hydrochloride) (Standard) is the analytical standard of Mefloquine (hydrochloride). This product is intended for research and analytical applications. Mefloquine hydrochloride (Mefloquin hydrochloride), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine hydrochloride is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. Mefloquine hydrochloride can be used for malaria, systemic lupus erythematosus and cancer research. -
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Rimtuzalcap (Standard)
0 ImagesCat. No.: HY-109160RCAS No.: 2167246-24-2Synonyms: CAD-1883 (Standard)Rimtuzalcap (Standard) is the analytical standard of Rimtuzalcap (HY-109160). This product is intended for research and analytical applications. Rimtuzalcap (CAD-1883) is a first-in-class selective positive allosteric modulator of small-conductance calcium-activated potassium channels (SK channels). Rimtuzalcap can be used for the research of movement disorders including essential tremor (ET) and spinocerebellar ataxia (SCA). -
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DCPIB (Standard)
0 ImagesCat. No.: HY-103371RCAS No.: 82749-70-0DCPIB (Standard) is the analytical standard of DCPIB (HY-103371). This product is intended for research and analytical applications. DCPIB is a selective, reversible and potent inhibitor of volume-regulated anion channels (VRAC). DCPIB voltage-dependently activates potassium channels TREK1 and TRAAK, and inhibits TRESK, TASK1 and TASK3 (IC50s: 0.14, 0.95, 50.72 μM, respectively). DCPIB is also a selective blocker of swelling-induced chloride current (ICl,swell), with an IC50 of 4.1 μM. DCPIB is a useful tool for investigating structure-function studies of K2P channels. -
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Flecainide (Standard)
0 ImagesFlecainide (Standard) is the analytical standard of Flecainide. This product is intended for research and analytical applications. Flecainide is an orally active antiarrhythmic agent. Flecainide can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT). -
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1-EBIO (Standard)
0 ImagesSynonyms: 1-Ethyl-2-benzimidazolinone (Standard)1-EBIO (1-Ethyl-2-benzimidazolinone) (Standard) is the analytical standard of 1-EBIO (HY-101360). This product is intended for research and analytical applications. 1-EBIO is an activator of Ca2+ sensitive K+ channels wirh an EC50 of 136 μM for KCa3.1. 1-EBIO induces Cl- secretion, K+ conductance, membrane hyperpolarization, and afterhyperpolarisation currents. 1-EBIO reduces epileptiform activity, seizure incidence, and rescues cells from Ionomycin (HY-13434)-induced death. -
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- Procainamide hydrochloride (Standard)
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Ropivacaine (Standard)
0 ImagesRopivacaine (Standard) is the analytical standard of Ropivacaine. This product is intended for research and analytical applications. Ropivacain is a potent sodium channel blocker. Ropivacain blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. Ropivacaine is used for the research of neuropathic pain management. -
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Tetramisole hydrochloride (Standard)
0 ImagesSynonyms: (±)-Tetramisole hydrochloride (Standard); DL-Tetramisole hydrochloride (Standard); R-829 (Standard)Tetramisole hydrochloride (Standard) is the analytical standard of Tetramisole (hydrochloride). This product is intended for research and analytical applications. Tetramisole hydrochloride is an orally active, selective inward rectifier potassium channel agonist with an EC50 of approximately 30 μM for the Kir2.1 subunit. Tetramisole hydrochloride is also an anti-nematode agent that blocks neuromuscular transmission by non-competitive depolarization. Tetramisole hydrochloride promotes the forward transport of Kir2.1 channels, hyperpolarizes the resting potential (RP), shortens the action potential duration (APD), inhibits intracellular calcium overload and the PKA signaling pathway, and exerts anti-arrhythmic and anti-myocardial remodeling activities. Tetramisole hydrochloride can be used in cardiac electrophysiology research and research related to myocardial ischemia and heart failure. -
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ML335 (Standard)
0 ImagesCat. No.: HY-104005RCAS No.: 825658-06-8 -
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6-O-Desmethyl donepezil
0 ImagesCat. No.: HY-133925CAS No.: 120013-56-1 -
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