Potassium Channel
KcsA
Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.
All Product Categories
-
Potassium Channel Inhibitors
(693)
View all products
-
Potassium Channel Agonists
(31)
View all products
-
Potassium Channel Antagonists
(39)
View all products
-
Potassium Channel Activators
(242)
View all products
-
Potassium Channel Modulators
(44)
View all products
-
Potassium Channel Chemical
(1)
View all products
-
Potassium Channel Controls
(11)
View all products
-
Potassium Channel Related Products (1155)
Related Products (1155)
-
Antibodies (6)
-
Related Compound Screening Libraries (1)
-
GEA 857
0 ImagesCat. No.: HY-117223CAS No.: 120493-42-7GEA 857 is a structural analog of the Serotonin (HY-B1473A) uptake blocker Alaproclate (HY-164011). GEA 857 enhances responses induced by muscarinic receptor agonists by inhibiting certain calcium-dependent potassium channels on membranes, a blockade that can enhance or prolong the muscarinic cholinergic effects. GEA 857 can be used in research on neurodegenerative diseases.
-
Phe-Met-Arg-Phe, amide acetate
0 ImagesCat. No.: HY-P0249BCAS No.: 152165-14-5Phe-Met-Arg-Phe, amide acetate dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons.
-
Drofenine
0 ImagesDrofenine (Cycloadiphene; Hexahydroadiphenine) is an brain-penetrant antispasmodic agent. Drofenine is a Kv2.1 channel inhibitor with human IC50 of 9.53 μM. Drofenine is a butyrylcholinesterase (BChE) inhibitor with Ki of 0.003 mM, and is a TRPV3 activator. Drofenine blocks Kv2.1-dependent potassium efflux, inhibits Kv2.1/JNK/NF-κB and IkBa/NF-kB signaling, suppresses Kv2.1 mRNA/protein expression. Drofenine suppresses oligomeric Aβ-induced microglial NLRP3 inflammasome activation and neuronal Tau hyperphosphorylation, improves cognitive impairment, promotes neurite outgrowth. Drofenine induces calcium influx in keratinocytes and exert cytotoxicity against keratinocytes. Drofenine ameliorates diabetic peripheral neuropathy -like pathology. Drofenine can be used for the researches of Alzheimer's disease, diabetic peripheral neuropathy and smooth muscle spasm.
-
Mitiglinide calcium hydrate-d8
0 ImagesCat. No.: HY-W777434Mitiglinide (calcium hydrate)-d8 is the deuterium labeled Mitiglinide (calcium hydrate) (HY-B0682A). Mitiglinide calcium hydrate (KAD-1229), an insulinotropic agent, is an ATP-sensitive K+ (KATP) channel antagonist. Mitiglinide calcium hydrate is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel). Mitiglinide Calcium hydrate can be used for the research of type 2 diabetes.
-
Diazoxide-d3
0 ImagesCat. No.: HY-B1140SCAS No.: 1432063-51-8Synonyms: Sch-6783-d3; SRG-95213-d3Diazoxide-d3 is deuterium labeled Diazoxide. Diazoxide (Sch-6783) is an ATP-sensitive potassium channel activator, has the potential for hyperinsulinism treatment.
-
CK-1649 chloride
0 ImagesCat. No.: HY-19049CAS No.: 125883-03-6CK-1649 chloride is a class III antiarrhythmic agent. CK-1649 chloride can inhibit potassium channel activity.
-
Kv3, Channel Containing Protein (567-585)
0 ImagesCat. No.: HY-P1886Kv3, Channel Containing Protein (567-585) corresponds to amino acids 567 to 585 fragment of the Kv3.1b channel containing protein. Kv3 channel protein is expressed by parvalbumin (PV)-containing pallidal neurons .
-
HsTX1
0 ImagesCat. No.: HY-P5182CAS No.: 201948-00-7HsTX1, from the scorpion Heterometrus spinnifer, is a 34-residue, C-terminally amidated peptide cross-linked by four disulfide bridges. HsTX1, an the inhibitor of potassium channel, with IC50 for Kv1.3 of 12 pM inhibits TEM cell activation and attenuates inflammation in autoimmunity.
-
Lanceotoxin A
0 ImagesCat. No.: HY-124396CAS No.: 93771-82-5Lanceotoxin A is a potent potassium channel inhibitor with activity in regulating cell membrane potential. Lanceotoxin A showed a significant negative correlation with extracellular metabolites in patients after metabolic surgery. The presence of lanceotoxin A may affect the composition of intestinal microorganisms and its association with insulin resistance. Lanceotoxin A may play an important role in the improvement of metabolic syndrome and diabetes.
-
LQFM020
0 ImagesCat. No.: HY-173618CAS No.: 1431459-41-4LQFM020 is an orally active pyrazole derivative. LQFM020 inhibits Ca+ and activates K+ and NO/cGMP channels to inhibit vasoconstriction. LQFM020 has anti-inflammatory and anti-analgesic activities.
-
Immuno modulator-1
0 ImagesCat. No.: HY-153952CAS No.: 2757469-20-6Immuno modulator-1 (compound 22) inhibits TNFα and IL-2 secretion in human peripheral blood mononuclear cells (hPBMC), with IC50 values of 4.7 and 26 nM, respectively. Immuno modulator-1 shows hERG potassium channel blocking effect, with Inhibitory percentage of 20% at 3 μM.
-
VU714 oxalate
0 ImagesCat. No.: HY-120226ACAS No.: 474625-52-0VU714 oxalate is a Kir7.1 channel inhibitor that enhances block by structurally unrelated inhibitors and influences the pharmacology of Kir channels through its interactions with key residues.
-
WAY-123398
0 ImagesCat. No.: HY-117528CAS No.: 138490-53-6WAY-123398 is a class III antiarrhythmic agent. WAY-123398 is a selective blocker of the delayed rectifier K+ current.
-
Quinidine-13C, d2 hydrochloride
0 ImagesCat. No.: HY-B1751S1Quinidine-13C, d2 hydrochloride is the 13C, d2 labeled Quinidine hydrochloride (HY-W115674). Quinidine hydrochloride is an orally active antiarrhythmic agent. Quinidine hydrochloride reduces the expression level of P-gp, inhibits P-gp-mediated efflux, increases the intracellular accumulation of P-gp substrates, induces PARP cleavage and Caspase-3 activation, and elevates the proportion of Apoptotic cells at the sub-G1 phase. Quinidine hydrochloride exerts sustained block and open-channel block effects on IK(f). Quinidine hydrochloride alters the urinary metabolic ratio of Amphetamine, modulates the Pentylenetetrazol-induced seizure threshold, and regulates the anticonvulsant effect of Dextromethorphan. Quinidine hydrochloride can be used in studies related to uterine sarcoma and seizures.
-
LY 97241
0 ImagesCat. No.: HY-119211CAS No.: 72456-63-4LY 97241 accelerates the apparent rate of inactivation of transient outward K current. LY 97241 is an antiarrhythmic drug.
-
BRL-32872
0 ImagesCat. No.: HY-19117CAS No.: 113241-47-7BRL-32872 is a potent human ether-a-go-go-related gene (hERG) potassium channel blocker (IC50=241 nM in isolated cardiomyocytes; 19.8 nM in HEK293 cells). BRL-32872 is promising for research of cardiac arrhythmias (e.g., atrial/ventricular rhythms) .
-
Norfluoxetine hydrochloride (Standard)
0 ImagesCat. No.: HY-W011235RCAS No.: 57226-68-3Norfluoxetine hydrochloride (Standard) is the analytical standard of Norfluoxetine hydrochloride (HY-W011235). This product is intended for research and analytical applications. Norfluoxetine hydrochloride is the active metabolite of the antidepressant Fluoxetine (HY-B0102); it is also a TREK-2 K2P potassium channel inhibitor. Norfluoxetine hydrochloride exhibits neuroimmunological activity, induces apoptosis in primary microglial cells, and inhibits the release of pro-inflammatory factors. Norfluoxetine hydrochloride inhibits high-threshold voltage-gated Ca2+ currents in neurons with an EC50 of 20.4 μM. Norfluoxetine hydrochloride can be used in research related to depression, ischemic stroke, and epilepsy.
