Potassium Channel
KcsA
Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.
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Potassium Channel Inhibitors
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Potassium Channel Agonists
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Potassium Channel Antagonists
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Potassium Channel Activators
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Potassium Channel Modulators
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Potassium Channel Chemical
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Potassium Channel Controls
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Potassium Channel Related Products (1155)
Related Products (1155)
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Antibodies (6)
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Related Compound Screening Libraries (1)
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NE-10133
0 ImagesCat. No.: HY-182646CAS No.: 149889-02-1NE-10133 is a ISK and IKS potassium channel (Potassium Channel) inhibitor. NE-10133 inhibits voltage-dependent and slowly activated delayed rectifier potassium currents. NE-10133 exhibits class III antiarrhythmic activity. NE-10133 is applicable for research related to arrhythmias.
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BTS-67582
0 ImagesCat. No.: HY-19174CAS No.: 161748-40-9BTS-67582 is an orally active nonsulfonylurea insulinotropic agent and potassium channel blocker. BTS-67582 affects the K+ ATP channel in the islet cell but at a different binding site than the sulfonylureas. BTS-67582 is an antidiabetic agent.
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Cisapride-d6
0 ImagesCat. No.: HY-14149SCAS No.: 2738376-71-9Synonyms: R51619-d6; (±)-Cisaprid-d6Cisapride-d6 (R51619-d6) is the deuterated-labeled Cisapride (HY-14149). Cisapride (R 51619) is an orally active, selective 5-HT4 receptor agonist with an EC50 of 140 nM. Cisapride also acts as an hERG potassium channel blocker with an IC50 of 9.4 nM. Cisapride exerts gastrointestinal prokinetic effects by activating 5-HT4 receptors, but it also blocks the hERG potassium channel responsible for the repolarization phase of cardiac action potentials, delaying repolarization and thus prolonging the action potential duration. Cisapride can be used in research related to gastrointestinal dysfunction, gastroesophageal reflux disease, functional dyspepsia, chronic gastritis, gastroparesis, ulcerative colitis and necrotizing enterocolitis.
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TMEM175 modulator 3
0 ImagesCat. No.: HY-181622CAS No.: 3115239-67-0TMEM175 modulator 3 (Compound 14) is a TMEM175 modulator. TMEM175 modulator 3 can be used in research on neurodegenerative diseases.
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TRP-PK1
0 ImagesCat. No.: HY-P12352TRP-PK1 is a polypeptide. TRP-PK1 can be derived from the fourth transmembrane segment of TRPV4. TRP-PK1 can insert into the phospholipid bilayer. TRP-PK1 self-assembles to form K+-permeable channels, mediates K+ flux, hyperpolarizes the membrane potential of vascular smooth muscle, relaxes agonist-induced vasoconstriction, and lowers mean arterial pressure. TRP-PK1 enhances the tumor-targeting capability of cell membrane vesicles and displays Angiopep-2 (HY-P2341) on the surface of engineered vesicles. TRP-PK1 can be used for research on glioblastoma multiforme, head and neck cancer, and hypertension.
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Noxiustoxin
0 ImagesCat. No.: HY-P2710CAS No.: 85205-49-8Noxiustoxin is a toxin from the venom of the Mexican scorpion Centruroides noxius which block voltage-dependent potassium channel (Kv1.3, IC50 = 360 nM), and calcium-activated potassium channel. Noxiustoxin plays an important role in neuroinflammatory disease.
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Heteropodatoxin-2
0 ImagesCat. No.: HY-P5785CAS No.: 741730-12-1Heteropodatoxin-2, a peptides of 30-amino acid, is a heteropodatoxin. Heteropodatoxin-2 blocks Kv4.2 current expressed in Xenopus laevis oocytes in a voltage-dependent manner, with less block at more positive potentials.
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Flupirtine-d6 hydrochloride
0 ImagesCat. No.: HY-W709349SSynonyms: D 9998-d6 hydrochlorideFlupirtine-d6 (D 9998-d6) hydrochloride is the deuterium labeled Flupirtine hydrochloride (HY-W709349). Flupirtine hydrochloride is an orally active, blood-brain barrier-crossing non-opioid analgesic and neuroprotective agent. Flupirtine hydrochloride is a neuronal potassium channel opener (Kv7 activator), a NMDA receptor antagonist and a GABA receptor activator. Flupirtine hydrochloride stabilizes blood-brain-barrier integrity, reduces oxidative stress and brain leukocyte infiltration, enhances angioneurogenesis, suppresses calcium influx, stabilizes neuronal resting membrane potential, and counteracts focal cerebral ischemia. Flupirtine hydrochloride exhibits analgesic, muscle relaxant properties, protects neurons from excitotoxic, ischemic, or cytokine-mediated death. Flupirtine hydrochloride functions as a non-opioid analgesic without antipyretic or antiphlogistic properties, shows no relevant affinity to opiate receptor. Flupirtine hydrochloride can be used for the research of focal cerebral ischemia, pain, Alzheimer’s disease, or multiple sclerosis.
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20(S)-Ginsenoside Rg3 (Standard)
0 ImagesSynonyms: 20(S)-Propanaxadiol(Standard); S-ginsenoside Rg3 (Standard)20(S)-Ginsenoside Rg3 (Standard) is the analytical standard of 20(S)-Ginsenoside Rg3. This product is intended for research and analytical applications. 20(S)-Ginsenoside Rg3 is the main component of Panax ginseng C. A. Meyer. Ginsenoside Rg3 inhibits Na+ and hKv1.4 channel with IC50s of 32.2±4.5 and 32.6±2.2 μM, respectively. 20(S)-Ginsenoside Rg3 also inhibits Aβ levels, NF-κB activity, and COX-2 expression.
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Almokalant
0 ImagesCat. No.: HY-106855CAS No.: 123955-10-2Synonyms: H 234/09Almokalant is a class III antiarrhythmic agent, acts as a potassium channel blocker, and inhibits a specific component (Ikr) of the time-dependent delayed rectifier K+ current.
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HCN2 modulator-5
0 ImagesCat. No.: HY-186059ACAS No.: 3080809-02-2
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Kv3 activator-1
0 ImagesKv3 activator-1 is a Kv3 family voltage-gated potassium channel activator. Kv3 activator-1 reverses mechanical hyperalgesia in rat models of neuropathic and inflammatory pain, with rapid onset and long-lasting, dose-related effects. Kv3 activator-1 can be used for the research of pain.
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Uridine 5'-monophosphate-13C9,15N2 dilithium
0 ImagesCat. No.: HY-101981S3CAS No.: 2483830-55-1Synonyms: 5'-Uridylic acid-13C9,15N2 dilithiumUridine 5'-monophosphate-13C9,15N2 (5'- Uridylic acid-13C9,15N2) dilithium is 13C and 15N-labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea.
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C3001a
0 ImagesCat. No.: HY-160789CAS No.: 2415154-29-7C3001a is a selective TREK-1 and TREK-2 channel activator with EC50 values of 12.81 μM and 11.31 μM, respectively. C3001a does not affect other two-pore domain K+ (K2P) channels. C3001a binds to the cryptic binding site formed by P1 and TM4 in TREK-1. C3001a can be used for the study of pain and pancreatitis.
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TWIK-1/TREK-1-IN-2
0 ImagesCat. No.: HY-149537CAS No.: 1440532-32-0TWIK-1/TREK-1-IN-2 (Compound 2g) is a TWIK-1/TREK-1 inhibitor. TWIK-1/TREK-1-IN-2 inhibits TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 10.13 μM and 15.5 μM. TWIK-1/TREK-1-IN-2 is an antidepressant.
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4-Hydroxytolbutamide-d9-1
0 ImagesCat. No.: HY-100641S1Synonyms: Hydroxytolbutamide-d9-14-Hydroxytolbutamide-d9-1 (Hydroxytolbutamide-d9-1) is the deuterium labeled 4-Hydroxytolbutamide (HY-100641). 4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic.
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SRP-001
0 ImagesCat. No.: HY-182589CAS No.: 2290606-49-2SRP-001 is an orally active, blood-brain barrier-permeable analgesic and antipyretic agent. SRP-001 reduces the expression level of FAAH, mildly inhibits hERG currents, generates AM404 (HY-101388), and maintains the integrity of hepatic tight junctions. SRP-001 exerts analgesic, antipyretic, and antinociceptive effects.
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VU0531245
0 ImagesCat. No.: HY-156335CAS No.: 1396749-92-0Synonyms: VU245VU0531245 is a SLACK channel inhibitor (IC50: 2.1 μM).
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Succinic acid sodium
0 ImagesCat. No.: HY-W396714CAS No.: 14047-56-4Synonyms: Wormwood acid sodiumSuccinic acid sodium is a potent and orally active anxiolytic agent. Succinic acid sodium shows inhibitory effects on colonic epithelial cell proliferation in vivo. Succinic acid sodium can down-regulate the expression of KCNMB1 (potassium channel subunit β1) and TET1 (ten?eleven translocation 1). Succinic acid sodium can be used for gestational hypertension research.
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Lumula
0 ImagesCat. No.: HY-158936CAS No.: 511229-72-4Synonyms: Maxeyprost; Unoprostone N-ethyl amideLumula (Maxeyprost) is an ethyl amide derivative of Unoprostone (HY-106916).
