STAT Ligand

AK-068 is a high-affinity and selective STAT6 ligand, with a K_i of 6 nM. AK-068 demonstrates at least >150- and >85-fold binding selectivity over STAT5A (K_i >1 μM) and STAT5B (K_i >500 μM) proteins, respectively. AK-068 is a ligand for target protein for PROTAC, can be used for synthesis of PROTACs.

STAT6 ligand-1 is a ligand for STAT6. STAT6 ligand-1 can be used for synthesizing PROTACs such as STAT6 degrader-2 (HY-176857).

(+)-Theta-cypermethrin is a stereoisomer of Cypermethrin (HY-B0829) that possesses blood-brain barrier penetration ability and binds to AKT1, SRC, STAT3 and EGFR with high affinity. (+)-Theta-cypermethrin reduces the amplitude of delayed rectifier potassium channel currents, shifts the steady-state activation curve to negative potentials, and shifts the steady-state inactivation curve to negative potentials at higher concentrations. (+)-Theta-cypermethrin induces abnormal electrical activity in rat hippocampal neurons. (+)-Theta-cypermethrin causes chronic respiratory system damage and exhibits neurotoxicity.

SI-191 is a STAT3 inhibitor and a target protein ligand. SI-191 inhibits the growth of cancer cells. SI-191 can be used in the research of acute leukemia and lymphoma. SI-191 can be used for the synthesis of PROTAC SD-91 (HY-150251).

STAT6 ligand-1 is a ligand of STAT6. STAT6 ligand-1 can be used to synthesize PROTACs, such as Compound 22.

AK305 is a small-molecule ligand for the SH2 domains of STAT5A, STAT5B and STAT6, with a K_i of 0.4 μM for STAT6 and a K_i of 1.0 μM for both STAT5A and STAT5B. AK305 exhibits only very low or no cell growth inhibitory activity in leukemia cells and does not alter STAT protein levels. AK305 serves as the STAT5 ligand for AK-2292 (HY-148813), a STAT5 PROTAC degrader. AK305 can be used in the research of acute myeloid leukemia.

STAT3 ligand 7 is a STAT3 ligand and can be synthesized using PROTACs, such as PROTAC STAT3 degrader-2 (HY-153023).