Drug Isomer
Drug Isomer
Drug isomers are compounds with the same molecular formula but different atomic arrangements or spatial configurations. They are divided into structural isomers and stereoisomers, and have different biological activities, safety and metabolic characteristics. Drug isomers can be used as drug improvement groups or drug efficacy control groups. For example, Carvedilol has higher bioavailability and better safety than (R)-Carvedilol.
References:
- [1]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14. [Content Brief]
- [2]. Andersson T. Single-isomer drugs: true therapeutic advances. Clin Pharmacokinet. 2004;43(5):279-85. [Content Brief]
- [3]. Chhabra N, et al. A review of drug isomerism and its significance. Int J Appl Basic Med Res. 2013 Jan;3(1):16-8. [Content Brief]
All Product Categories
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Drug Isomer Related Products (542)
Related Products (542)
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(S)-Opnurasib
0 ImagesSynonyms: (S)-JDQ-443; (S)-NVP-JDQ443
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(R)-Vitamin D2
0 ImagesSynonyms: (R)-Ergocalciferol; (R)-Calciferol; (R)-Ercalciol(R)-Vitamin D2 is the isomer of Vitamin D2 (HY-76542), and can be used as an experimental control. Vitamin D2 (Ergocalciferol), drived from plant sources or dietary supplements, could be used as supplement of Vitamin D.
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CR-1-30-B
0 ImagesCR-1-30-B is an inactive enantiomer of CR-1-31-B. CR-1-30-B, as a control, is inactive against eIF4A and has no apparent effect on the induction of MUC1-C translation.
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(S)-Leucic acid (Standard)
0 ImagesCat. No.: HY-30215RCAS No.: 13748-90-8Synonyms: (S)-2-Hydroxy-4-methylpentanoic acid (Standard)(S)-Leucic acid (Standard) ((S)-2-Hydroxy-4-methylpentanoic acid (Standard)) is the analytical standard of (S)-Leucic acid (HY-30215). This product is intended for research and analytical applications. (S)-Leucic acid ((S)-2-Hydroxy-4-methylpentanoic acid) is an α-hydroxy acid found in the fermentation products of Bacillus granulobacter pectinovorum. (S)-Leucic acid is an isomer of Leucic acid (HY-30216A) and a leucine metabolite. (S)-Leucic acid acts as a D-unit subunit precursor in the biosynthesis of cryptophycins in the Nostoc cyanobacterial symbiont. (S)-Leucic acid is used in metabolism-related studies.
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Fulvestrant (S enantiomer)
0 ImagesCat. No.: HY-13636ACAS No.: 1316849-17-8Synonyms: ICI 182780 (S enantiomer); ZD 9238 (S enantiomer); ZM 182780 (S enantiomer)Fulvestrant (ICI 182780; ZD 9238) S enantiomer is the S-enantiomer of Fulvestrant (HY-13636), a potent estrogen receptor inhibitor. Fulvestrant binds to and blocks the estrogen receptor, promotes its degradation, and thereby inhibits receptor dimerization, nucleocytoplasmic shuttling and transcriptional activity. Fulvestrant effectively blocks estrogen signaling, MAPK pathway activation and ER-regulated protein expression. Fulvestrant induces apoptosis, inhibits the proliferation of breast cancer and prolactinoma cells, and reduces the mineralization level, alkaline phosphatase activity and osteocalcin expression of preosteoblasts. Prenatal exposure to Fulvestrant impairs ovarian follicular development and causes ovarian structural damage. Fulvestrant has been widely used in studies related to breast cancer, prolactinoma and other conditions.
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GDC-0834 Racemate
0 ImagesCat. No.: HY-15427ACAS No.: 1133432-46-8
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(Rac)-Baxdrostat
0 ImagesSynonyms: (Rac)-CIN-107(Rac)-Baxdrostat is the isomer of Baxdrostat (HY-132809), and can be used as an experimental control. Baxdrostat is a aldosterone synthase inhibitor.
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(E/Z)-4,4'-Dicyanostilbene
0 ImagesCat. No.: HY-W112166CAS No.: 6292-62-2(E/Z)-4,4'-Dicyanostilbene is the isomer of 4,4'-Dicyanostilbene (HY-W112166A), and can be used as an experimental control. 4,4'-Dicyanostilbene (compound 43) is a potent antimalarial agent against the Dd2 strain, with an EC50 of 27 nM. 4,4'-Dicyanostilbene exhibits in vivo efficacy against methicillin-resistant Staphylococcus aureus (MRSA).
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XL177B
0 ImagesSynonyms: (R)-XL177AXL177B is an inactive (R) enantiomer of XL177A (HY-138794). XL177B has no effect on CD86 or HLA-DR expression on pDCs. XL177B serves as a negative control. XL177B can be used in the research of multiple myeloma.
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trans-Doxercalciferol
0 Imagestrans-Doxercalciferol is an isomer of Doxercalciferol (HY-32348). Doxercalciferol is a vitamin D receptor agonist. Doxercalciferol reduces proteinuria, podocyte injury, mesangial expansion, extracellular matrix accumulation, macrophage infiltration, oxidative stress, proinflammatory cytokines, profibrotic growth factors, renal neutral lipid accumulation, albuminuria and glomerulosclerosis. Doxercalciferol alleviates high-salt diet-induced myocardial hypertrophy. trans-Doxercalciferol is used for the research of diet-induced obesity-related nephropathy, diabetic nephropathy, myocardial hypertrophy, cardiac dysfunction and secondary hyperparathyroidism.
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(R,S)-MK-8457
0 ImagesCat. No.: HY-112319CAS No.: 1312518-84-5
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Tacrolimus 8-epimer
0 ImagesCat. No.: HY-Z8754CAS No.: 129212-35-7Synonyms: Tacrolimus EP impurity D; 8-epi-TacrolimusTacrolimus 8-epimer (Tacrolimus EP impurity D) is the C-8 epimer and degradation impurity of Tacrolimus (HY-13756). Tacrolimus 8-epimer forms via base-catalyzed epimerization of Tacrolimus, and also generates under iodine-catalyzed free radical conditions. Tacrolimus 8-epimer is mainly used as a reference substance for impurity analysis, pharmaceutical quality control and stability-related studies of Tacrolimus.
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(S)-3-Hydroxymyristic acid
0 ImagesSynonyms: (3S)-3-Hydroxytetradecanoic acid(S)-3-Hydroxymyristic acid ((3S)-3-Hydroxytetradecanoic acid) is the enantiomer of (R)-3-hydroxytetradecanoic acid (a lipid A component) (HY-W288375), and enhances the inherent immune adjuvant activity of lipid A.
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(R)-Chiglitazar
0 ImagesCat. No.: HY-106266CSynonyms: (R)-Carfloglitazar(R)-Chiglitazar is the enantiomer of Chiglitazar (HY-106266). Chiglitazar is a peroxisome PPAR agonist that can be used for the study of type 2 diabetes.
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(1R)-LSN3160440
0 ImagesCat. No.: HY-153193APurity: 98.43%(1R)-LSN3160440 is the (1R) chiral isomer of LSN3160440 (HY-153193). LSN3160440 is an allosteric modulator of GLP-1R.
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(rac)-Valategrast
0 ImagesCat. No.: HY-14190ACAS No.: 2935063-80-0Synonyms: (rac)-R-411 free base(rac)-Valategrast ((rac)-R-411 free base) is a racemic compound of Valategrast (HY-14190). Valategrast is a potent, orally active dual antagonist of integrin α4β1 (VLA-4) and α4β7. Valategrast may be used in research on chronic obstructive pulmonary disease (COPD) and asthma.
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3,4-Methylenedioxypropiophenone
0 ImagesCat. No.: HY-W016621CAS No.: 28281-49-43,4-Methylenedioxypropiophenone (Compound 4) is an isomer of 3,4-methylenedioxyphenyl-2-propanone. 3,4-Methylenedioxypropiophenone has potent activity against leishmania.
