mGluR
Metabotropic glutamate receptors
mGluR (metabotropic glutamate receptor) is a type of glutamate receptor that are active through an indirect metabotropic process. They are members of thegroup C family of G-protein-coupled receptors, or GPCRs. Like all glutamate receptors, mGluRs bind with glutamate, an amino acid that functions as an excitatoryneurotransmitter. The mGluRs perform a variety of functions in the central and peripheral nervous systems: mGluRs are involved in learning, memory, anxiety, and the perception of pain. mGluRs are found in pre- and postsynaptic neurons in synapses of the hippocampus, cerebellum, and the cerebral cortex, as well as other parts of the brain and in peripheral tissues. Eight different types of mGluRs, labeled mGluR1 to mGluR8, are divided into groups I, II, and III. Receptor types are grouped based on receptor structure and physiological activity.
mGluR Isoform Specific Products
All Product Categories
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mGluR Related Products (400)
Related Products (400)
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Antibodies (8)
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mGluR Isoform Comparison
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MSOP (Standard)
0 ImagesCat. No.: HY-101226RCAS No.: 66515-29-5
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DL-AP4 (Standard)
0 ImagesCat. No.: HY-100743RCAS No.: 6323-99-5Synonyms: 2-Amino-4-phosphonobutyric acid (Standard)DL-AP4 (Standard) is the analytical standard of DL-AP4. This product is intended for research and analytical applications. DL-AP4 (2-Amino-4-phosphonobutyric acid) is a glutamate antagonist. DL-AP4 behaves as a competitive inhibitor of glutamate binding with an apparent Kd of 66 μM. DL-AP4 can be used for the research of central nervous system and visual system.
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AZD 2066 sulfate
0 ImagesCat. No.: HY-110255CCAS No.: 934282-57-2AZD 2066 sulfate is a mGluR5 antagonist and also the sulfate salt of 4-(5-{(1R)-1-ethoxy}-4-methyl-4H-1,2,4-triazol-3-yl) pyridine. AZD 2066 sulfate is used in research on various diseases including Alzheimer's disease, autism, and obesity.
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DCB (Standard)
0 ImagesCat. No.: HY-103561RCAS No.: 6971-97-7DCB (Standard) is the analytical standard of DCB (HY-103561). This product is intended for research and analytical applications. DCB (3,3′-dichlorobenzaldazine) is an neutral allosteric modulator of the metabotropic glutamate receptor metabotropic glutamate receptor subtype 5 (mGluR5). DCB blocks the positive allosteric regulation of mGluRs (mGluR5) with the help of 3,3′-difluorobenzaldazine (DFB). DCB shows the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB).
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(E/Z)-SIB-1893 (Standard)
0 Images(E/Z)-SIB-1893 (Standard) is the analytical standard of (E/Z)-SIB-1893 (HY-102094). This product is intended for research and analytical applications. (E/Z)-SIB-1893 is a racemic compound of (E)-SIB-1893 and (Z)-SIB-1893 isomers. (E)-SIB-1893 is a selective non-competitive metabotropic glutamate subtype 5 receptor (mGluR5) antagonist.
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Nefiracetam (Standard)
0 ImagesSynonyms: DM9384 (Standard); DZL-221 (Standard)Nefiracetam (Standard) is a cognition-enhancing agent. Nefiracetam is an activator of nAChR, N-methyl-D-aspartate receptor (NMDAR), mGluR5, PKC, gamma-aminobutyric acid (GABA), and N/L-type Ca2+ channels. Nefiracetam promotes neuroplasticity and enhances neuroprotection. Nefiracetam can be used in Alzheimer's disease, epilepsy, and cerebral ischemia research.
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VU0469650 (Standard)
0 ImagesCat. No.: HY-110191RCAS No.: 1443748-47-7
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YM-298198
0 ImagesCat. No.: HY-129794CAS No.: 748758-45-4YM-298198 is a potent mGlu1 receptor with an IC50 of 24 nM. YM-298198 can be used in the study of neurological disease.
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VU0422288 (Standard)
0 ImagesCat. No.: HY-110190RCAS No.: 1630936-95-6Synonyms: ML396 (Standard)VU0422288 (Standard) is the analytical standard of VU0422288 (HY-110190). This product is intended for research and analytical applications. VU0422288 (ML396) is a positive allosteric modulator of group III mGluRs. VU0422288 inhibits mGluRs with EC50s of 125 nM, 146 nM, and 108 nM for mGluR4, mGluR7, and mGluR8, respectively in calcium mobilization assays. VU0422288 reverses deficits in contextual fear memory, social recognition, and apneas in Rett syndrome (RTT) model mice.
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SIB-1757 (Standard)
0 ImagesCat. No.: HY-102095RCAS No.: 31993-01-8
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AZD-2066 hydrochloride
0 ImagesCat. No.: HY-110255BCAS No.: 934338-70-2AZD-2066 hydrochloride is a selective, orally active and blood-brain barrier-permeating mGluR5 antagonist. AZD 2066 hydrochloride activates the BDNF/trkB signaling pathway. AZD 2066 hydrochloride can be used in the research of neuropathic pain, major depressive disorder and gastroesophageal reflux disease.
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Ro4491533
0 ImagesCat. No.: HY-118285CAS No.: 579482-31-8Ro4491533 is a selective, negative allosteric mGluR2/3 receptor modulator that is equally effective on both subtypes. Ro4491533 can completely block glutamate-induced calcium mobilization and glutamate-induced [35S]GTPγS binding accumulation. Ro4491533 has good pharmacokinetic properties in mice and rats, high oral bioavailability, and can pass through the blood-brain barrier. Ro4491533 can also reverse the motor inhibition effect of LY379268 in mice and show antidepressant activity in the forced swim test and tail suspension test.
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(RS)-4C3HPG
0 ImagesCat. No.: HY-100840ACAS No.: 134052-66-7Synonyms: 4-Carboxy-3-hydroxyphenylglycine(RS)-4C3HPG (4-Carboxy-3-hydroxyphenylglycine) is an effective competitive antagonist at the metabotropic glutamate receptor 1 (mGluR1) in the central nervous system, and it is also an agonist at mGluR2/3. (RS)-4C3HPG exhibits neuroprotective effects in an acute global ischemia rat model.
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FPTQ (Standard)
0 ImagesCat. No.: HY-100382RCAS No.: 864863-72-9FPTQ (Standard) is the analytical standard of FPTQ (HY-100382). This product is intended for research and analytical applications. FPTQ is potent mGluR1 antagonist with IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively. FPTQ has anti-oxidant and anti-inflammatory effects in vitro and in vivo.
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(RS)-APICA (Standard)
0 ImagesCat. No.: HY-101375RCAS No.: 170847-18-4(RS)-APICA (Standard) is the analytical standard of (RS)-APICA (HY-101375). This product is intended for research and analytical applications. (RS)-APICA is a selective group II metabotropic glutamate receptor (mGluR II) antagonist. (RS)-APICA shows potential neuroprotective effect.
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O-Phospho-D-serine
0 ImagesCat. No.: HY-15129ACAS No.: 73913-63-0Synonyms: D-Serine O-phosphate; D-SOPO-Phospho-D-serine (D-SOP) is the D-configurational enantiomer of O-Phospho-L-serine (HY-15129). O-Phospho-D-serine inhibits L-[3H]glutamate binding to APB-sensitive sites in rat brain synaptic plasma membranes, with a Ki of 303 μM. Compared with the L-configurational form, D-SOP does not significantly activate the tested mGluR at 1 mM, and it is mainly used in studies related to the stereoselectivity of phosphatidylserine and mGluR ligands.
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Fasoracetam (Standard)
0 ImagesSynonyms: NS 105 (Standard)Fasoracetam (Standard) is the analytical standard of Fasoracetam (HY-107481). This product is intended for research and analytical applications. Fasoracetam (NS 105) is the activator of metabotropic glutamate receptor (mGluR). Fasoracetam (NS 105) has the potential for the research of attention-deficit hyperactivity disorder (ADHD) and Alzheimer's disease (AD).
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AZD 9272 (Standard)
0 ImagesCat. No.: HY-110254RCAS No.: 327056-26-8AZD 9272 (Standard) is the analytical standard of AZD 9272. This product is intended for research and analytical applications. AZD 9272 is a brain penetrant mGluR5 antagonist.
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VU0650786 (Standard)
0 ImagesCat. No.: HY-108710RCAS No.: 1809085-30-0VU0650786 (Standard) is the analytical standard of VU0650786 (HY-108710). This product is intended for research and analytical applications. VU0650786 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM), with an IC50 of 392 nM. VU0650786 has antidepressant and anxiolytic activity in rodents.
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PHCCC (Standard)
0 ImagesCat. No.: HY-100409RCAS No.: 179068-02-1
