Transmembrane Glycoprotein

Transmembrane glycoproteins are important components of cell membranes and are characterized by oligosaccharide chains covalently linked to polypeptide chains. Glycosylation sites are mainly located in their extracellular regions, achieved by N-linked glycosylation (linked to asparagine residues) or O-linked glycosylation (linked to serine or threonine residues). Sugar chains not only provide structural stability to proteins but also confer functional specificity. Many transmembrane glycoproteins are receptors, such as G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs). Most （clusters of differentiation）CD molecules are also transmembrane glycoproteins expressed on the surface of antigen-presenting cells^[1]^[2].

References:

[1]. L Franco, et al. The transmembrane glycoprotein CD38 is a catalytically active transporter responsible for generation and influx of the second messenger cyclic ADP-ribose across membranes. FASEB J. 1998 Nov;12(14):1507-20. [Content Brief]

[2]. Kumi Oshima, et al. SHPS-1, a multifunctional transmembrane glycoprotein. FEBS Lett. 2002 May 22;519(1-3):1-7. [Content Brief]

Transmembrane Glycoprotein 関連製品 (368):

By Effects:	Inhibitors (229) Agonists (7) Ligands (14) Antagonists (7) Activators (10) Modulators (5)

製品番号	製品名	製品効果	純度	構造式

HY-P991928

SGN-CD48A Antibody
SGN-CD48A Antibody an anti-human CD48 antibody. SGN-CD48A Antibody can generate antibody drug conjugate (ADC) (SGN-CD48A) with a microtubule inhibitor Monomethyl auristatin E (MMAE) (HY-15162). SGN-CD48A Antibody can be used for the study of multiple myeloma.

HY-P10183

CD36 Peptide P (139-155), Cys conjugated	Inhibitor
CD36 Peptide P (139-155), Cys conjugated is a Cys labelled CD36 Peptide, and can inhibit the immunoadsorption of CD36 by OKM5.

HY-182724

PSB-18422	Agonist
PSB-18422 is a GPR17 agonist, with an EC₅₀ of 0.0279 μM for humans, 0.47 μM for rats, 0.753 μM for mice, and a human K_i of 1.46 μM. PSB-18422 triggers intracellular calcium mobilization via cross-species activation of GPR17. PSB-18422 can be used in the research of allergic bronchial inflammation.

HY-P5472

Tumour-associated MUC1 epitope
Tumour-associated MUC1 epitope is a biological active peptide. (This sequence is the hallmark of MUC1 mucin. MUC1 is a highly glycosylated type I transmembrane glycoprotein with a unique extracellular domain consisting of a variable number of tandem repeats (VNTR) of this 20 amino acid peptide. It is overexpressed on the cell surface of many human adenocarcinomas and hematological malignancies, including multiple myeloma and B-cell lymphoma, making MUC1 broadly applicable target for immunotherapeutic strategies.)

HY-E70190

Tyrosylprotein Sulfotransferase 2	Activator
Tyrosylprotein Sulfotransferase 2 (TPST-2) is a subtype of TPST. Tyrosylprotein Sulfotransferase is a 54- to 50-kDa integral membrane glycoprotein of the trans-Golgi network found in essentially all tissues investigated, catalyzing the tyrosine O-sulfation of soluble and membrane proteins passing through this compartment.

HY-P11127

MBP (111-129)
MBP (111-129) is a polypeptide that constitutes an immunodominant epitope cluster restricted by HLA-DRB10401. MBP (111-129) is an antagonist for the clone HD4-1C2 TCR* and an agonist for clone MS2-3C8 TCR. MBP (111-129) can be used for on multiple sclerosis and T cell biology.

HY-P991305

AGEN-1571
AGEN-1571 is a human IgG1 monoclonal antibody (mAb) targeting ILT2. AGEN-1571 promotes adaptive and innate immune responses. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001)

HY-P991829

Anti-Mouse TIM-1/CD365 Antibody (RMT1-10)	Inhibitor
Anti-Mouse TIM-1/CD365 Antibody (RMT1-10) reacts with mouse T cell immunoglobulin and mucin domain 1 (TIM-1). Anti-Mouse TIM-1/CD365 Antibody (RMT1-10) is effective in promoting allograft survival through blocking TIM-1. Recommend Isotype Controls: Rat IgG2a kappa, Isotype Control (HY-P990679).

HY-P990235

Anti-Mouse ICOSL/CD275 (D265A) Antibody (HK5.3)	Inhibitor
Anti-Mouse ICOSL/CD275 (D265A) Antibody (HK5.3) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to mouse ICOSL/CD275. Anti-Mouse ICOSL/CD275 (D265A) Antibody (HK5.3) is a chimeric antibody of the original HK5.3 antibody (HY-P990123). Anti-Mouse ICOSL/CD275 (D265A) Antibody (HK5.3) contains the D265A mutation region. Anti-Mouse ICOSL/CD275 (D265A) Antibody (HK5.3) can neutralize ICOSL. Anti-Mouse ICOSL/CD275 (D265A) Antibody (HK5.3) can be used for researches of inflammation and infection.

HY-P992443

PP6373 Antibody	Inhibitor
PP6373 Antibody is a human IgG1 kappa monoclonal CD24 antibody. The recommended isotype control is HY-P99001.

HY-P0168A

Cibinetide acetate	Agonist
Cibinetide (ARA290) acetate is an erythropoietin (EPO) derivative that acts as a specific agonist of the erythropoietin/CD131 heteroreceptor. ICibinetide acetate can be used in the research of neurological disorders.

HY-164311

GPR17 modulator-1	Modulator
GPR17 modulator-1 (Compound 2-046) is a modulator for G protein-coupled receptor 17 GPR17, with an IC₅₀<10 nM for hGPR17 in CHO. GPR17 modulator-1 exhibits moderate pharmacokinetic characteristics in mice. GPR17 modulator-1 ix blood-brain barrier (BBB) permeable.

HY-P991826

Anti-Mouse CD80 Antibody (16-10A1)	Inhibitor
Anti-Mouse CD80 Antibody (16-10A1) reacts with mouse CD80 that can block CD80 in vivo. Recommend Isotype Controls: Polyclonal Armenian hamster IgG, Isotype Control (HY-P990305).

HY-P992488

ZV05	Inhibitor
ZV05 (ZV0501 Antibody) is an anti-5T4 monoclonal antibody with an EC₅₀ of 4.3 ng/mL against h5T4. ZV05 does not induce apoptosis or interfere with cell cycle progression. ZV05 accumulates specifically in 5T4-positive tumor xenografts. ZV05 can serve as the antibody component of antibody-active molecule conjugates (ADCs) to bind the 5T4 glycoprotein, thereby enabling targeted delivery of toxins. ZV05 is used in studies of 5T4-positive cancers, including triple-negative breast cancer.

HY-108864

Epoetin alfa	Agonist
Epoetin alfa (Epogen) is a recombinant human erythropoietin whose amino acid sequence and biological activity are identical to those of endogenous erythropoietin (EPO). Epoetin alfa is a direct agonist of the EPO receptor (EPOR) on the surface of erythroid progenitor cells, and promotes the production and maturation of red blood cells. Epoetin alfa can be used for research on myelodysplastic syndrome-related anemia and hematological malignancies.

HY-P990843

Anti-Glycophorin A (type M) Antibody (6A7M)
Anti-Glycophorin A (type M) Antibody (6A7M) is a kind of mouse IgG1 κ chimeric antibody inhibitor, targeting to human Glycophorin A (type M). Anti-Glycophorin A (type M) reacts with the human glycophorin A (GPA) M allele also known as CD235a. Anti-Glycophorin A (type M) can be used for the research of infection, such as human immunodeficiency virus (HIV).

HY-P1822A

BDC2.5 mimotope 1040-31 TFA	Inhibitor
BDC2.5 mimotope 1040-31 TFA, a BDC2.5 TCR reactive peptide, is a strong agonistic peptide for diabetogenic T cell clone BDC2.5, and the 1040-31 peptide is specific for BDC 2.5 TCR Tg⁺T cells.

HY-P992255

Anti-LAIR1 Antibody
Anti-LAIR1 Antibody is a monoclonal antibody that targets LAIR1. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-LAIR1 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P992088

Zolimomab	Inhibitor
Zolimomab is an anti-human monoclonal antibody targeting-CD5. Zolimomab binds to the CD5 antigen found on mature T-cells. Zolimomab can be used for the research of graft-versus-host disease (GVHD).

HY-P2696A

EP 80317 acetate	Ligand	99.16%
EP 80317 acetate is a selective CD36 ligand. EP 80317 acetate protects the heart against damage and dysfunction elicited by myocardial ischaemia and reperfusion (MI/R), along with a transient reduction in peripheral lipolysis. EP 80317 acetate can be used for the study of cardiovascular disease.

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