2. Anti-infection
  3. Bacterial Antibiotic
  4. Alafosfalin

Alafosfalin is an inhibitor of cell wall biosynthesis. Alafosfalin is a phosphonodipeptide with antibacterial properties.

For research use only. We do not sell to patients.

Alafosfalin Chemical Structure

Alafosfalin Chemical Structure

CAS No. : 60668-24-8

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5 mg USD 65 In-stock
10 mg USD 100 In-stock
25 mg USD 190 In-stock
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Based on 1 publication(s) in Google Scholar

Alafosfalin Related Antibodies

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Description

Alafosfalin is an inhibitor of cell wall biosynthesis. Alafosfalin is a phosphonodipeptide with antibacterial properties[1].

IC50 & Target

β-lactam

 

In Vitro

Alafosfalin is highly active against Escherichia coli and moderately active against Serratia, Klebsiella, Enterobacter, and Citrobacter, but less active against gram-positive organisms than were beta-lactams such as cephazolin or ampicillin and inactive against indole-positive Proteus, Pseudomonas, and Acinetobacter[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Alafosfalin Related Antibodies
In Vivo

After s.c. administration to rats, Alafosfalin is rapidly absorbed with half-lives (t1/2) of approximately 20 minutes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pairs of male SpragueDawley rats (250 to 350 g)[2]
Dosage: 20, 100, and 500 mg/ kg (single doses) or 800 mg/kg per day for 14 days (Pharmacokinetic Analysis)
Administration: Administrated by s.c.
Result: Rapidly absorbed; peak concentrations were found within 20 minutes of dosing with half-lives of approximately 20 minutes.
Molecular Weight

196.14

Formula

C5H13N2O4P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OP(O)([C@@H](NC([C@@H](N)C)=O)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (1274.60 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0984 mL 25.4920 mL 50.9840 mL
5 mM 1.0197 mL 5.0984 mL 10.1968 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.0984 mL 25.4920 mL 50.9840 mL 127.4600 mL
5 mM 1.0197 mL 5.0984 mL 10.1968 mL 25.4920 mL
10 mM 0.5098 mL 2.5492 mL 5.0984 mL 12.7460 mL
15 mM 0.3399 mL 1.6995 mL 3.3989 mL 8.4973 mL
20 mM 0.2549 mL 1.2746 mL 2.5492 mL 6.3730 mL
25 mM 0.2039 mL 1.0197 mL 2.0394 mL 5.0984 mL
30 mM 0.1699 mL 0.8497 mL 1.6995 mL 4.2487 mL
40 mM 0.1275 mL 0.6373 mL 1.2746 mL 3.1865 mL
50 mM 0.1020 mL 0.5098 mL 1.0197 mL 2.5492 mL
60 mM 0.0850 mL 0.4249 mL 0.8497 mL 2.1243 mL
80 mM 0.0637 mL 0.3186 mL 0.6373 mL 1.5932 mL
100 mM 0.0510 mL 0.2549 mL 0.5098 mL 1.2746 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Alafosfalin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alafosfalin60668-24-8BacterialAntibioticcellwallphosphonodipeptideantibacterialEscherichia coliInhibitorinhibitorinhibit

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