Alafosfalin 

Alafosfalin is an inhibitor of cell wall biosynthesis. Alafosfalin is a phosphonodipeptide with antibacterial properties^[1].

Alafosfalin is highly active against Escherichia coli and moderately active against Serratia, Klebsiella, Enterobacter, and Citrobacter, but less active against gram-positive organisms than were beta-lactams such as cephazolin or ampicillin and inactive against indole-positive Proteus, Pseudomonas, and Acinetobacter^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

After s.c. administration to rats, Alafosfalin is rapidly absorbed with half-lives (t_1/2) of approximately 20 minutes^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

196.14

C₅H₁₃N₂O₄P

60668-24-8

OP(O)([[email protected]@H](NC([[email protected]@H](N)C)=O)C)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. H B Maruyama, et al. Alafosfalin, a New Inhibitor of Cell Wall Biosynthesis: In Vitro Activity Against Urinary Isolates in Japan and Potentiation With Beta-Lactams. Antimicrob Agents Chemother. 1979 Oct;16(4):444-51.  [Content Brief]

  [2]. J G Allen, et al. Phosphonopeptides as Antibacterial Agents: Metabolism and Pharmacokinetics of Alafosfalin in Animals and Humans. Antimicrob Agents Chemother. 1979 Sep;16(3):306-13.  [Content Brief]