Anti-inflammatory agent 91
Anti-inflammatory agent 91 (Compound 4o) is an anti-inflammatory agent that can reduce inflammatory cytokines by inhibiting the STAT3 and NF-κB signaling pathways. Anti-inflammatory agent 91 can be used in research to improve skin inflammation associated with psoriasis.
For research use only. We do not sell to patients.
- Formula: C23H16ClF2NO6S
- Molecular Weight:507.89
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Anti-inflammatory agent 91 (Compound 4o) (10-80 μM; 24 h) has no significant effect on HaCaT cell viability[1].
Anti-inflammatory agent 91 (10-40 μM; 2 h) significantly reduces NO (IC50= 19.5 μM), TNF-α, IL-6 (RAW264.7) and IL-17A (HaCaT) levels in LPS (1 μg/mL; 24 h)-induced RAW264.7 and HaCaT cells, demonstrating anti-inflammatory activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Imiquimod-induced Psoriasis mice model[1].
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Dosage:25 mg/kg; 50 mg/kg; 100 mg/kg
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Administration:Apply topically to skin once daily for 5 days. 12 hours after applying 5% imiquimod cream.
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Result:Significantly inhibited the expression of inflammatory factors IL-6, IL-17A, IL-22, IL-23, and TNF-α in the serum of IMQ-induced psoriasis-like mice.
Significantly reduced the erythema and scales of the dorsal lesions of the mice compared to the imiquimod (IMQ) group.
Significantly reduced histopathological damage.
Effectively inhibited the expression of p65, STAT3, and p-STAT3, and slightly reduced the expression of p-p65.
Chemical Information
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Molecular Weight 507.89
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Formula C23H16ClF2NO6S
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SMILES
O=S(C1=CC(F)=C(Cl)C=C1F)(NCCOC2=CC3=C(C(O)=C2)C(C=C(C4=CC=CC=C4)O3)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-inflammatory agent 91 Related Classifications
HY-159144 Related Classifications
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