Antipsychotic agent-2
Antipsychotic agent-2 (Compound 11) is a potent antipsychotic agent. Antipsychotic agent-2 shows affinities for 5-HT1A, 5-HT2A, 5-HT2C, D2 and H1 receptors with Kis of 56.6, 66.7, 552, 596 and 1140 nM, respectively. Antipsychotic agent-2 has BBB permeability.
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- CAS No.: 3043786-44-0
- Formula: C22H26FN5O
- Molecular Weight:395.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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5-HT1A Receptor 160 nM (EC50) |
5-HT1A Receptor |
5-HT2A Receptor |
5-HT2C Receptor |
5-HT2A Receptor 96.4 nM (Kb) |
D2 Receptor 45.7 nM (Kb) |
Antipsychotic agent-2 (Compound 11) antagonizes the inhibition of Forskolin (HY-15371)-stimulated cAMP production elicited by 10-6 M dopamine in CHO-K1 cells stably expressing human D2 receptors, indicative of D2 antagonistic activity (Kb=45.7 nM)[1].
Antipsychotic agent-2 inhibits the Forskolin-stimulated cAMP production in HEK293 cells stably expressing 5-HT1A receptors in a concentration-dependent manner, indicative of 5-HT1A agonistic activity (EC50=160 nM), while it behaves as 5-HT2A antagonists, antagonizing the inositol phosphate production stimulated by 10-6 5-HT in CHO-K1 cells expressing 5-HT2A receptors (Kb=96.4 nM)[1].
Antipsychotic agent-2 (0.1-10 μM) is a relatively low potency CYP3A4 inducer[1].
Antipsychotic agent-2 (0.3-30 μM; 72 h) represents good safety profile and shows significant cytotoxic activity only at 30 μM concentration in SH-SY5Y cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Antipsychotic agent-2 (40 mg/kg; i.p.; once) decreases amphetamine-induced hyperactivity in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Naive Swiss male mice, amphetamine-induced hyperactivity[1]
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Dosage:40 mg/kg
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Administration:IP, once
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Result:Decreased amphetamine-induced hyperactivity.
Chemical Information
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CAS No. 3043786-44-0
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Molecular Weight 395.47
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Formula C22H26FN5O
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SMILES
O=C(C1=NNC2=CC=CC=C21)NCCCCN3CCN(CC3)C4=CC=C(C=C4)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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