Antipsychotic agent-2

Antipsychotic agent-2 (Compound 11) antagonizes the inhibition of Forskolin (HY-15371)-stimulated cAMP production elicited by 10^-6 M dopamine in CHO-K1 cells stably expressing human D₂ receptors, indicative of D₂ antagonistic activity (K_b=45.7 nM)^[1].
Antipsychotic agent-2 inhibits the Forskolin-stimulated cAMP production in HEK293 cells stably expressing 5-HT_1A receptors in a concentration-dependent manner, indicative of 5-HT_1A agonistic activity (EC₅₀=160 nM), while it behaves as 5-HT_2A antagonists, antagonizing the inositol phosphate production stimulated by 10^-6 5-HT in CHO-K1 cells expressing 5-HT_2A receptors (K_b=96.4 nM)^[1].
Antipsychotic agent-2 (0.1-10 μM) is a relatively low potency CYP3A4 inducer^[1].
Antipsychotic agent-2 (0.3-30 μM; 72 h) represents good safety profile and shows significant cytotoxic activity only at 30 μM concentration in SH-SY5Y cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.