country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-144830

Copy Link Print Information

6BrCaQ

6BrCaQ is a potent mitochondrial heat shock protein TRAP1 inhibitor, with antiproliferative activity. 6BrCaQ can be used in the synthesis of 6BrCaQ-TPP conjugates.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 954416-67-2
Formel: C₁₈H₁₅BrN₂O₃
Molecular Weight:387.23

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

6BrCaQ Chemical Structure

CAS. Nr.: 954416-67-2

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

6BrCaQ is a potent mitochondrial heat shock protein TRAP1 inhibitor, with antiproliferative activity. 6BrCaQ can be used in the synthesis of 6BrCaQ-TPP conjugates^[1].

Alle HSP Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	IC₅₀	8 μM Compound: 6BrCaQ	Antiproliferative activity against human Caco2 cells assessed as inhibition of cell proliferation Antiproliferative activity against human Caco2 cells assessed as inhibition of cell proliferation	[PMID: 24992077]
HT-29	IC₅₀	20 μM Compound: 6BrCaQ	Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 34952432]
IGROV-1	IC₅₀	5 μM Compound: 6BrCaQ	Antiproliferative activity against human IGROV1 cells assessed as inhibition of cell proliferation Antiproliferative activity against human IGROV1 cells assessed as inhibition of cell proliferation	[PMID: 24992077]
Ishikawa	IC₅₀	2 μM Compound: 6BrCaQ	Antiproliferative activity against human Ishikawa cells assessed as inhibition of cell proliferation Antiproliferative activity against human Ishikawa cells assessed as inhibition of cell proliferation	[PMID: 24992077]
LP-1	GI₅₀	6.2 μM Compound: 6BrCaQ	Growth inhibition of human LP-1 cells after 72 hrs by MTS assay Growth inhibition of human LP-1 cells after 72 hrs by MTS assay	[PMID: 24992077]
MCF7	GI₅₀	7 μM Compound: 6BrCaQ	Growth inhibition of ER-positive human MCF7 cells after 72 hrs by MTT assay Growth inhibition of ER-positive human MCF7 cells after 72 hrs by MTT assay	[PMID: 24992077]
MCF7	IC₅₀	7 μM Compound: 6BrCaQ	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation	[PMID: 24992077]
MCF7	IC₅₀	7 μM Compound: 6BrCaQ	Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth	[PMID: 34952432]
MDA-MB-231	GI₅₀	0.06 μM Compound: 6BrCaQ	Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by Celltiter Glo assay Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by Celltiter Glo assay	[PMID: 34952432]
MDA-MB-231	GI₅₀	2 μM Compound: 6BrCaQ	Growth inhibition of ER-negative human MDA-MB-231 cells after 72 hrs by MTT assay Growth inhibition of ER-negative human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 24992077]
MDA-MB-231	IC₅₀	2 μM Compound: 6BrCaQ	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation	[PMID: 24992077]
PC-3	GI₅₀	10 μM Compound: 6BrCaQ	Growth inhibition of human PC3 cells after 72 hrs by MTS assay Growth inhibition of human PC3 cells after 72 hrs by MTS assay	[PMID: 24992077]
RPMI-8226	GI₅₀	5 μM Compound: 6BrCaQ	Growth inhibition of human RPMI8226 cells after 72 hrs by MTS assay Growth inhibition of human RPMI8226 cells after 72 hrs by MTS assay	[PMID: 24992077]

Chemical Information

CAS. Nr. 954416-67-2
Molecular Weight 387.23
Formel C₁₈H₁₅BrN₂O₃
SMILES

COC1=CC=C(C=C1)C(NC2=CC3=CC(Br)=CC=C3N(C2=O)C)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Mathieu C, et, al. Synthesis and antiproliferative activity of 6BrCaQ-TPP conjugates for targeting the mitochondrial heat shock protein TRAP1. Eur J Med Chem. 2022 Feb 5;229:114052. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

6BrCaQ

Alle HSP Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

6BrCaQ Related Classifications

HY-144830 Related Classifications