Art. -Nr.: HY-17596

Closantel

11 Cited Publications

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Based on 11 publication(s) in Google Scholar

Closantel is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel is a potent and highly specific Onchocerca volvulus chitinase (OvCHT1) inhibitor with an IC₅₀ of 1.6 μM and a K_i of 468 nM. Closantel inhibits the O. volvulus L3 to L4 molt of developing.

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Reinheit: 98.65%
CAS. Nr.: 57808-65-8
Formel: C₂₂H₁₄Cl₂I₂N₂O₂
Molecular Weight:663.07

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Closantel Chemical Structure

CAS. Nr.: 57808-65-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Publications (11)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Parasite Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	CC₅₀	75 μM Compound: Closantel	Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by Alamar Blue reporter assay Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by Alamar Blue reporter assay	[PMID: 30392371]
HEK293	IC₅₀	3 μM Compound: Closantel	Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assay Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assay	[PMID: 28230985]

In Vitro

Closantel, a known anthelmintic drug, is highly specific forfilarial family chitinases compared to those fromprotozoans and the human chitinase, human chitotriosidase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 57808-65-8
Appearance Solid
Molecular Weight 663.07
Formel C₂₂H₁₄Cl₂I₂N₂O₂
Color White to off-white
SMILES

O=C(NC1=CC(Cl)=C(C(C2=CC=C(Cl)C=C2)C#N)C=C1C)C3=CC(I)=CC(I)=C3O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (11)

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Journal Impact Factor

Acta Pharm Sin B

STK39 inhibits antiviral immune response by inhibiting DCAF1-mediated PP2A degradation. [Abstract]

2025 Mar;15(3):1535-1551. PMID: 40370558

Closantel purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Mar;15(3):1535-1551. [Abstract]

HEK293T cells were pretreated with 20 μmol/L Closantel for 1 h and then infected with indicated MOI HSV-1 for 24 h. HSV-1 RNA replicates were detected by qPCR.
Autophagy

Duloxetine ameliorates cerebral ischemic injury by inhibiting autophagy. [Abstract]

2026 Mar 5. PMID: 41787744
Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576
J Mol Cell Biol

TMPRSS2 and SARS-CoV-2 SPIKE interaction assay for uHTS. [Abstract]

2023 Aug 3;15(3):mjad017. PMID: 36921991
Microbiologyopen

Antibacterial and Antibiofilm Activity of Closantel Against Staphylococcus epidermidis. [Abstract]

2025 Oct;14(5):e70062. PMID: 40926309
Cancers

WNK1 Kinase Stimulates Angiogenesis to Promote Tumor Growth and Metastasis. [Abstract]

2020 Mar 2;12(3):575. PMID: 32131390

Closantel purchased from MedChemExpress. Usage Cited in: Cancers. 2020 Mar 2;12(3):575. [Abstract]

Representative images of embryos before and after treated with DMSO (vehicle), PTK787, WNK463 or Closantel (0.15 μM).

Closantel purchased from MedChemExpress. Usage Cited in: Cancers. 2020 Mar 2;12(3):575. [Abstract]

Representative H&E-stained sections of intestinal tract of RPIA transgenic fish treated with Closantel (1.5 μM).
J Biol Chem

α-Crystallin chaperone mimetic drugs inhibit lens γ-crystallin aggregation: Potential role for cataract prevention. [Abstract]

2022 Oct;298(10):102417. PMID: 36037967
Drug Repurposing

2026 Jan 30.
bioRxiv

2025 March 01.
Università Vita-Salute San Raffaele

2022 Apr 08. 34.
L’UNIVERSITE GRENOBLE ALPES

2021 Apr 13.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 100 mg/mL (150.81 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.5081 mL

7.5407 mL

15.0814 mL

5 mM

0.3016 mL

1.5081 mL

3.0163 mL

10 mM

0.1508 mL

0.7541 mL

1.5081 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (3.77 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (3.77 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Amanda L Garner, et al. Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus. J Med Chem. 2011 Jun 9;54(11):3963-72. [Content Brief]

[2]. Amanda L Garner, et al. Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus. J Med Chem. 2011 Jun 9;54(11):3963-72. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.5081 mL	7.5407 mL	15.0814 mL	37.7034 mL
	5 mM	0.3016 mL	1.5081 mL	3.0163 mL	7.5407 mL
	10 mM	0.1508 mL	0.7541 mL	1.5081 mL	3.7703 mL
	15 mM	0.1005 mL	0.5027 mL	1.0054 mL	2.5136 mL
	20 mM	0.0754 mL	0.3770 mL	0.7541 mL	1.8852 mL
	25 mM	0.0603 mL	0.3016 mL	0.6033 mL	1.5081 mL
	30 mM	0.0503 mL	0.2514 mL	0.5027 mL	1.2568 mL
	40 mM	0.0377 mL	0.1885 mL	0.3770 mL	0.9426 mL
	50 mM	0.0302 mL	0.1508 mL	0.3016 mL	0.7541 mL
	60 mM	0.0251 mL	0.1257 mL	0.2514 mL	0.6284 mL
	80 mM	0.0189 mL	0.0943 mL	0.1885 mL	0.4713 mL
	100 mM	0.0151 mL	0.0754 mL	0.1508 mL	0.3770 mL

Keywords

Closantel

11 Cited Publications

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Closantel

Anti-Infection Compound Library

FDA Approved & Pharmacopeial Drug Library

Antiparasitic Compound library

Human Metabolite Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Publications Citing Use of MedChemExpress (MCE) Closantel

Alle Parasite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (11)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Closantel

Anti-Infection Compound Library

FDA Approved & Pharmacopeial Drug Library

Antiparasitic Compound library

Human Metabolite Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Publications Citing Use of MedChemExpress (MCE) Closantel

Alle Parasite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (11)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Closantel Related Classifications

HY-17596 Related Classifications