Art. -Nr.: HY-17371

Oxaliplatin

226 Cited Publications

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Based on 226 publication(s) in Google Scholar

Oxaliplatin is a DNA synthesis inhibitor. Oxaliplatin causes DNA crosslinking damage, prevents DNA replication and transcription and induces apoptosis. Oxaliplatin can be used for cancer research.

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Reinheit: 99.65%
CAS. Nr.: 61825-94-3
Formel: C₈H₁₄N₂O₄Pt
Molecular Weight:397.29

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Oxaliplatin Chemical Structure

CAS. Nr.: 61825-94-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
- Induced Disease Models
- Clinical Trial
Chemical Information
Publications (226)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC50: DNA synthesis^[1]

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

In Vitro

Oxaliplatin (24-72 hours; 2-128 μM; HCC, HCCLM3 and Hep3B cells) inhibits cell growth and induces apoptosis^[1].
Oxaliplatin (10 μM; 15-240 mins; CEM cells ) induces primary and secondary DNA lesions, including DNA cross-links (ISC) and DNA-protein cross-links (DPC)^[2].
Oxaliplatin (0.01 to 100 μM; 24 hours) potently inhibits bladder carcinoma cell lines RT4 and TCCSUP, ovarian carcinoma cell line A2780, colon carcinoma cell line HT-29, glioblastoma cell lines U-373MG and U-87MG, and melanoma cell lines SK-MEL-2 and HT-144 with IC₅₀ of 11 μM, 15 μM, 0.17 μM, 0.97 μM, 2.95 μM, 17.6 μM, 30.9 μM and 7.85 μM, respectively^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HCC, HCCLM3 and Hep3B cells
Concentration:

24, 48 and 72 hours
Incubation Time:

2, 4, 8, 16, 32, 64 and 128 μM
Result:

Decreased cell viability in a dose- and time-dependent manner.

Cell Cycle Analysis^[1]

Cell Line:

HCCLM3 and Hep3B cells
Concentration:

10 μM
Incubation Time:

24 hours
Result:

Increased the percentage of apoptotic cells (17.70% for HCCLM3 cells; 21.19% for Hep3B cells).

Cell Cycle Analysis^[1]

Cell Line:

HCCLM3 cells
Concentration:

10 μM
Incubation Time:

48 hours
Result:

Down-regulated the expression of Bcl-2 and Bcl-xL, and increased the expression of Bax.

In Vivo

Oxaliplatin (5-10 mg/kg; i.p.; for 32 days; nude mice) inhibits tumor growth^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Nude mice^[1]
Dosage:

5 and 10 mg/kg
Administration:

Intraperitoneal injection; for 32 days
Result:

Reduced tumor volume in HCCLM3 tumor xenografts.

Induced Disease Models

Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

1. Induction of acute chemotherapy-induced peripheral neuropathy (CINP)^[10]^[11]^[12]

Background

Oxaliplatin induces acute neuropathic pain through a multifaceted mechanism involving disruption of voltage-gated ion channels, activation of TRP channels, suppression of DNA transcription, mitochondrial dysfunction, and increased generation of reactive oxygen species (ROS)^[10].

Specific Modeling Methods

Rats: SD rats
Administration: Oxaliplatin (3, 5, 6 and 10 mg/kg) • i.p. • once
Rats: SD rats
Administration: Oxaliplatin (2 mg/kg) • i.p. • once
Mice: Male CD-1 mice
Administration: Oxaliplatin (10 mg/kg) • i.p. • once
Mice: Male C57BL/6 mice
Administration: Oxaliplatin (3 and 6 mg/kg) • i.p. • once
Mice: Male BALB/c mice
Administration: Oxaliplatin (5 mg/kg) • i.v. • once

Note

Oxaliplatin working solution is typically prepared in 5% glucose solution.

Modeling Indicators

Molecular changes: Activation of TRPA1/TRPM8 channels, voltage-gated Na⁺ channel dysfunction, and mild ROS elevation
Mechanical allodynia: Decreased paw withdrawal threshold (Von Frey test)
Cold allodynia: Decreased paw withdrawal latency (acetone test)
Motor function: No impairment (rotarod test), confirming pain specificity

2. Induction of chronic chemotherapy-induced peripheral neuropathy (CINP)^[10]^[11]^[12]

Background

Oxaliplatin-induced activation of TRPA1 channels on dorsal root ganglion (DRG) neurons triggers Ca²⁺ influx, leading to the accumulation of ROS, mitochondrial DNA (mtDNA) damage, disruption of the electron transport chain, and opening of the mitochondrial permeability transition pore (mPTP). These alterations subsequently impede ATP synthesis and promote neurotoxicity^[10].

Specific Modeling Methods

Rats: SD rats
Administration: Oxaliplatin (2.4 mg/kg) • i.p. • on days 1-3, 6-10, and 13-15
Rats: SD rats
Administration: Oxaliplatin (2 and 4 mg/kg) • i.p. • on days 1, 2, 3, 4, 5
Rats: SD rats
Administration: Oxaliplatin (6 mg/kg) • i.p. • on days 1,3, 5, 7
Rats: SD rats
Administration: Oxaliplatin (2.4, 3.2, and 4 mg/kg) • i.p. • twice weekly for 4.5 weeks
Rats: Wistar rats
Administration: Oxaliplatin (4 mg/kg) • i.p. • twice weekly for 4 weeks
Rats: Wistar rats
Administration: Oxaliplatin (6 mg/kg) • i.p. • once per day for 6 days
Rats: SD rats
Administration: Oxaliplatin (2 mg/kg) • i.v. • once per day for 5 days
Mice: C57BL/6J mice; BALB/c mice; ICR mice
Administration: Oxaliplatin (0.3 and 3 mg/kg) • i.p. • 5 consecutive days, followed by 2 days of rest, for two cycles
Mice: C57BL/6 mice
Administration: Oxaliplatin (3 mg/kg) • i.p. • 3 times per week for 4 weeks
Mice: CD-1 mice
Administration: Oxaliplatin (2.4 mg/kg) • i.p. • 5 consecutive days each week for 2 weeks
Mice: Swiss mice
Administration: Oxaliplatin (6 mg/kg) • i.p. • every 3 days over 6 days

Note

Oxaliplatin is typically prepared in 5% glucose solution.

Modeling Indicators

Molecular changes: Increased ROS levels, activation of TLR4/NF‑κB pathway (TNF‑α, IL‑1β), decreased ATP, and TRPA1 sensitization
Histological changes: Significant loss of intraepidermal nerve fibers (IENF) in hind paw skin
Mechanical allodynia: Decreased paw withdrawal threshold (Von Frey test)
Cold allodynia: Decreased paw withdrawal latency (acetone test)
Motor function: No impairment (rotarod test), confirming pain specificity
Nerve conduction velocity: Decreased sensory nerve conduction velocity (SNCV); normal motor nerve conduction velocity (MNCV)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 61825-94-3
Appearance Solid
Molecular Weight 397.29
Formel C₈H₁₄N₂O₄Pt
Color White to off-white
SMILES

O=C(O1)C(O[Pt]21[NH2][C@@H]3CCCC[C@H]3[NH2]2)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (226)

All In Vivo Efficacy StudyCell Proliferation/Viability AssayIF

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Signal Transduct Target Ther

Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]

2025 Dec 15;10(1):406. PMID: 41392286
Signal Transduct Target Ther

Elaiophylin triggers paraptosis and preferentially kills ovarian cancer drug-resistant cells by inducing MAPK hyperactivation. [Abstract]

2022 Sep 12;7(1):317. PMID: 36097006
Signal Transduct Target Ther

Cyst(e)ine in nutrition formulation promotes colon cancer growth and chemoresistance by activating mTORC1 and scavenging ROS. [Abstract]

2021 May 28;6(1):188. PMID: 34045438
Nat Med

Prospective observational study on biomarkers of response in pancreatic ductal adenocarcinoma. [Abstract]

2024 Mar;30(3):749-761. PMID: 38287168

Oxaliplatin purchased from MedChemExpress. Usage Cited in: Nat Med. 2024 Mar;30(3):749-761. [Abstract]

The relative cell viability of shCtl-, shNDUFB8-, and shCEMIP2-transfected cells was detected by XTT assay after paclitaxel plus gemcitabine treatment (A+G), single-agent 5-Fu (5-FU), and the FOLFIRINOX chemotherapy cocktail [FU+IRI+OXA: 5-FU+Irinotecan (SN-38) +Oxaliplatin (50 nM)] for 48h.
Nat Med

Stress-glucocorticoid-TSC22D3 axis compromises therapy-induced antitumor immunity. [Abstract]

2019 Sep;25(9):1428-1441. PMID: 31501614

Oxaliplatin purchased from MedChemExpress. Usage Cited in: Nat Med. 2019 Sep;25(9):1428-1441. [Abstract]

Quantification of CD3+IFN-γ+ T cells in lung lobes taken from urethane-induced primary lung cancer models (n = 5 mice for SD group, n = 6 mice for all the other groups). Three coronal sections containing five pulmonary lobes from each mouse near the maximal diameters are quantified. Each dot represents one view field. A representative result from two independent experiments is shown.
Cancer Cell

Dissecting genetic and immune drivers of heterogeneous responses to neoadjuvant immunochemotherapy in gastric cancer. [Abstract]

2026 Apr 13;44(4):809-830.e11. PMID: 41720086
Cancer Cell

Chemotherapy triggers immune evasion by fostering LEPR+ Kupffer cell differentiation in liver metastases. [Abstract]

2026 Mar 9;44(3):658-675.e12. PMID: 41687606
Cancer Cell

Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches. [Abstract]

2025 Sep 25:S1535-6108(25)00393-9. PMID: 41005303
Mol Cancer

Organoids derived from patients provide a new opportunity for research and individualized treatment of malignant peritoneal mesothelioma. [Abstract]

2024 Jan 10;23(1):12. PMID: 38200517
Nat Cancer

Mex3a marks drug-tolerant persister colorectal cancer cells that mediate relapse after chemotherapy. [Abstract]

2022 Sep;3(9):1052-1070. PMID: 35773527
Adv Mater

Efficacy and Safety Assessment of 5-Fluorouracil, Irinotecan and Oxaliplatin-Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy. [Abstract]

2026 Mar 15:e22617. PMID: 41834342
Gastroenterology

AGR2-Dependent Nuclear Import of RNA Polymerase II Constitutes a Specific Target of Pancreatic Ductal Adenocarcinoma in the Context of Wild-Type p53. [Abstract]

2021 Nov;161(5):1601-1614.e23. PMID: 34303658

Oxaliplatin purchased from MedChemExpress. Usage Cited in: Gastroenterology. 2021 Nov;161(5):1601-1614.e23. [Abstract]

Bar graphs show the GI50 of 5-fluoruracil (48 h), irinotecan (48 h), gemcitabine (48 h), paclitaxel (48 h), and oxaliplatin (48 h) in PDAC cells in combination with bioactive hexapeptides (NTAIYY and PTTIYY) or controls (saline and NTAIYA).
Nat Mach Intell

2026 Mar 4;8(3):351-371.
Drug Resist Updat

CEA-induced PI3K/AKT pathway activation through the binding of CEA to KRT1 contributes to oxaliplatin resistance in gastric cancer. [Abstract]

2024 Dec 3:78:101179. PMID: 39644827

Oxaliplatin purchased from MedChemExpress. Usage Cited in: Drug Resist Updat. 2024 Dec 3:78:101179. [Abstract]

Oxaliplatin (100 nM-4 μM; 48 h) inhibits CEA^high (AGS) and CEA^-⁠/lo (xhGC1) gastric cancer cells, with IC50 values of 150 nM and 2.2 μM, respectively.
JAMA Oncol

Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy for Patients With Locally Advanced Rectal Cancer: Long-term Results of the CAO/ARO/AIO-12 Randomized Clinical Trial. [Abstract]

2022 Jan 1;8(1):e215445. PMID: 34792531
Cell Mol Immunol

Arsenic trioxide elicits prophylactic and therapeutic immune responses against solid tumors by inducing necroptosis and ferroptosis. [Abstract]

2023 Jan;20(1):51-64. PMID: 36447031

Oxaliplatin purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2023 Jan;20(1):51-64. [Abstract]

Comparison of drug (Epirubicin hydrochloride, EPI; Daunorubicin hydrochloride, DNR; Vinorelbine ditartrate, VNR; Oxaliplatin, OXA; Vincristine, VCR; Artemisinin, ART; Colchicine, COL) cytotoxicity to TC1 cells at the indicated doses and time points measured with CCK-8 assays. R.U. (Relative unit) was calculated from the average O.D. values in each condition as the indicator of cell viability (n = 3).
Nat Cell Biol

Trafficking circuit of CD8+ T cells between the intestine and bone marrow governs antitumour immunity. [Abstract]

2024 Aug;26(8):1346-1358. PMID: 39039181
Cell Host Microbe

Bacteroides fragilis promotes chemoresistance in colorectal cancer, and its elimination by phage VA7 restores chemosensitivity. [Abstract]

2025 Jun 11;33(6):941-956.e10. PMID: 40446807
Cancer Res

A RIPK3-PGE2 Circuit Mediates Myeloid-Derived Suppressor Cell-Potentiated Colorectal Carcinogenesis. [Abstract]

2018 Oct 1;78(19):5586-5599. PMID: 30012671
Nat Commun

Ferroptosis-armed dendritic cell vaccines for glioma immunotherapy. [Abstract]

2026 May 7. PMID: 42098128
Nat Commun

Cleavage of CAD by caspase-3 determines the cancer cell fate during chemotherapy. [Abstract]

2025 May 30;16(1):5006. PMID: 40442064
Nat Commun

THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer. [Abstract]

2023 Sep 25;14(1):5534. PMID: 37749092
Cell Death Differ

Cell death-induced release of the pro-aging protein acyl CoA binding protein (ACBP) into the circulation. [Abstract]

2026 Jun 3. PMID: 42236908
Adv Sci (Weinh)

Deep Learning-Powered Scalable Cancer Organ Chip for Cancer Precision Medicine. [Abstract]

2026 Feb 3:e16660. PMID: 41632021
Adv Sci (Weinh)

PRMT5 Inhibitor Synergizes with Chemotherapy to Induce Resembling Mismatch Repair Deficiency and Enhance Anti-TIGIT Therapy in Microsatellite-Stable Colorectal Cancer. [Abstract]

2025 May 8:e2500271. PMID: 40344511
Adv Sci (Weinh)

Lactylation of HDAC1 Confers Resistance to Ferroptosis in Colorectal Cancer. [Abstract]

2025 Jan 31:e2408845. PMID: 39888307
Adv Sci (Weinh)

DNMT3a Downregulation Ttriggered Upregulation of GABAA Receptor in the mPFC Promotes Paclitaxel-Induced Pain and Anxiety in Male Mice. [Abstract]

2024 Dec 16:e2407387. PMID: 39679872
Adv Sci (Weinh)

YY2/BUB3 Axis promotes SAC Hyperactivation and Inhibits Colorectal Cancer Progression via Regulating Chromosomal Instability. [Abstract]

2024 Jul;11(26):e2308690. PMID: 38682484
Adv Sci (Weinh)

Micro-Engineered Organoid-on-a-Chip Based on Mesenchymal Stromal Cells to Predict Immunotherapy Responses of HCC Patients. [Abstract]

2023 Sep;10(27):e2302640. PMID: 37485650
Adv Sci (Weinh)

Inhibition of CDK1 Overcomes Oxaliplatin Resistance by Regulating ACSL4-mediated Ferroptosis in Colorectal Cancer. [Abstract]

2023 Sep;10(25):e2301088. PMID: 37428466
Chem Eng J

2025 Jun 6.
Chem Eng J

2023 Nov 17, 147466.
Biomaterials

Immune modulation of the liver metastatic colorectal cancer microenvironment via the oral CAPOX-mediated cGAS-STING pathway. [Abstract]

2024 Oct:310:122625. PMID: 38820768
J Exp Clin Cancer Res

Pyrotinib targeted EGFR/GRP78 mediated cell apoptosis in high EGFR gene copy number gastric cancer. [Abstract]

2025 Aug 19;44(1):245. PMID: 40830980
J Exp Clin Cancer Res

Overcoming high level adenosine-mediated immunosuppression by DZD2269, a potent and selective A2aR antagonist. [Abstract]

2022 Oct 14;41(1):302. PMID: 36229853
J Exp Clin Cancer Res

Pharmacological targeting PTK6 inhibits the JAK2/STAT3 sustained stemness and reverses chemoresistance of colorectal cancer. [Abstract]

2021 Sep 22;40(1):297. PMID: 34551797
J Exp Clin Cancer Res

miR-19b-3p promotes colon cancer proliferation and oxaliplatin-based chemoresistance by targeting SMAD4: validation by bioinformatics and experimental analyses. [Abstract]

2017 Sep 22;36(1):131. PMID: 28938919
J Nanobiotechnology

Oxygen vacancy-engineered bimetallic nanozymes for disrupting electron transport chain and synergistic multi-enzyme activity to reverse oxaliplatin resistance in colorectal cancer. [Abstract]

2025 May 16;23(1):352. PMID: 40380190
J Nanobiotechnology

Photoacoustic mediated multifunctional tumor antigen trapping nanoparticles inhibit the recurrence and metastasis of ovarian cancer by enhancing tumor immunogenicity. [Abstract]

2022 Nov 3;20(1):468. PMID: 36329515
Cell Discov

Single-cell profiling reveals molecular basis of malignant phenotypes and tumor microenvironments in small bowel adenocarcinomas. [Abstract]

2022 Sep 14;8(1):92. PMID: 36104333
Redox Biol

p53 and fatty acids collaborate to trigger ferroptosis via the FBXO2-FABP5 axis in colorectal cancer. [Abstract]

2026 Mar:90:104043. PMID: 41604941
Redox Biol

Redistribution of defective mitochondria-mediated dihydroorotate dehydrogenase imparts 5-fluorouracil resistance in colorectal cancer. [Abstract]

2024 May 23:73:103207. PMID: 38805974
J Control Release

Oxygen and oxaliplatin-loaded nanoparticles combined with photo-sonodynamic inducing enhanced immunogenic cell death in syngeneic mouse models of ovarian cancer. [Abstract]

2021 Apr 10:332:448-459. PMID: 33662456
Gut Microbes

Fusobacterium nucleatum induces chemoresistance in colorectal cancer by inhibiting pyroptosis via the Hippo pathway. [Abstract]

2024 Jan-Dec;16(1):2333790. PMID: 38533566
MedComm (2020)

Gallium complex K6 inhibits colorectal cancer by increasing ROS levels to induce DNA damage and enhance phosphatase and tensin homolog activity. [Abstract]

2024 Jul 24;5(8):e665. PMID: 39049965
Cell Rep Med

Sex-biased intratumoral microbiome influences tumor molecular and immune landscape and disease outcomes. [Abstract]

2026 May 19;7(5):102757. PMID: 42013847
Cell Rep Med

Enhancing gastric cancer immunotherapy: Insights from multi-omics analysis and innovations in photodynamic-chemotherapy nanoplatforms. [Abstract]

2026 Mar 17;7(3):102635. PMID: 41747719
J Immunother Cancer

Memory B cell subset shapes antitumor immunity and response to PD-1 blockade in mismatch repair-deficient colorectal cancers. [Abstract]

2026 Jan 8;14(1):e012121. PMID: 41506788
J Immunother Cancer

Targeting VCP enhances colorectal cancer therapy through STING stabilization. [Abstract]

2025 Nov 19;13(11):e012652. PMID: 41260904
Cell Rep Med

CAN-Scan: A multi-omic phenotype-driven precision oncology platform identifies prognostic biomarkers of therapy response for colorectal cancer. [Abstract]

2025 Apr 2:102053. PMID: 40187357
J Immunother Cancer

Hyperbaric oxygen facilitates teniposide-induced cGAS-STING activation to enhance the antitumor efficacy of PD-1 antibody in HCC. [Abstract]

2022 Aug;10(8):e004006. PMID: 36002188
J Exp Med

Resolvins suppress tumor growth and enhance cancer therapy. [Abstract]

2018 Jan 2;215(1):115-140. PMID: 29191914
Pharmacol Res

CDC7 stabilized by KRAS signaling reactivation impairs chemosensitivity in KRAS-mutant colorectal cancer. [Abstract]

2025 Dec:222:108027. PMID: 41207349
Pharmacol Res

Time-dependent proteomics and drug response in expanding cancer cells. [Abstract]

2024 May 9:204:107208. PMID: 38729587
Cancer Lett

HOXC8-activated TRIM22/NF-κB pathway promotes stemness in colorectal cancer. [Abstract]

2026 Jan 28:638:218156. PMID: 41265630
Cancer Lett

Tumor-derived CCL5 recruits CCR1+ macrophages to suppress apoptosis and drive proliferation in duodenal adenocarcinoma. [Abstract]

2025 Sep 25:634:218064. PMID: 41015267
Cancer Lett

Traditional medicine Bazi Bushen potentiates immunosurveillance of senescent liver cancer cells via cGAS-STING signaling activation in macrophages. [Abstract]

2025 Feb 8:217544. PMID: 39929434
Cancer Lett

The CAIX inhibitor SLC-0111 exerts anti-cancer activity on gastric cancer cell lines and resensitizes resistant cells to 5-Fluorouracil, taxane-derived, and platinum-based drugs. [Abstract]

2023 Sep 1:571:216338. PMID: 37549770
Cancer Lett

De novo pyrimidine synthesis fuels glycolysis and confers chemoresistance in gastric cancer. [Abstract]

2022 Nov 28:549:215837. PMID: 35921972
Cancer Lett

IRE1α-targeting downregulates ABC transporters and overcomes drug resistance of colon cancer cells. [Abstract]

2020 Apr 28;476:67-74. PMID: 32061752
Int J Biol Sci

Repurposing Oxiconazole against Colorectal Cancer via PRDX2-mediated Autophagy Arrest. [Abstract]

2022 May 21;18(9):3747-3761. PMID: 35813474
Cell Death Dis

The EHMT2-MBLAC2 axis suppresses ribosomal DNA transcription in response to nucleolar DNA damage. [Abstract]

2026 Mar 18;17(1):320. PMID: 41851073
Adv Healthc Mater

Decellularized Extracellular Matrix Scaffolds to Engineer the Dormant Landscape of Microscopic Colorectal Cancer Liver Metastasis. [Abstract]

2025 Oct 13:e01791. PMID: 41083747
Cell Death Dis

Chemotherapy-induced macrophage CXCL7 expression drives tumor chemoresistance via the STAT1/PHGDH-serine metabolism axis and SAM paracrine feedback to M2 polarization. [Abstract]

2025 May 14;16(1):379. PMID: 40368902
Cell Death Dis

Mitochondrial, metabolic and bioenergetic adaptations drive plasticity of colorectal cancer cells and shape their chemosensitivity. [Abstract]

2025 Apr 5;16(1):253. PMID: 40185729
Cell Death Dis

Peroxisomal membrane protein PMP70 confers drug resistance in colorectal cancer. [Abstract]

2025 Apr 14;16(1):293. PMID: 40229252
Cell Death Dis

Inhibition of KLF5 promotes ferroptosis via the ZEB1/HMOX1 axis to enhance sensitivity to oxaliplatin in cancer cells. [Abstract]

2025 Jan 18;16(1):28. PMID: 39827156
Cell Death Dis

Hypermethylation of CDKN2A CpG island drives resistance to PRC2 inhibitors in SWI/SNF loss-of-function tumors. [Abstract]

2024 Nov 5;15(11):794. PMID: 39500892
Cell Death Dis

Upregulation of CRABP2 by TET1-mediated DNA hydroxymethylation attenuates mitochondrial apoptosis and promotes oxaliplatin resistance in gastric cancer. [Abstract]

2022 Oct 4;13(10):848. PMID: 36195596
Acta Biomater

Metal-organic framework-mediated multifunctional nanoparticles for combined chemo-photothermal therapy and enhanced immunotherapy against colorectal cancer. [Abstract]

2022 May;144:132-141. PMID: 35307591
Cell Death Dis

ECHS1, an interacting protein of LASP1, induces sphingolipid-metabolism imbalance to promote colorectal cancer progression by regulating ceramide glycosylation. [Abstract]

2021 Oct 6;12(10):911. PMID: 34615856
Cell Death Dis

MCT1 relieves osimertinib-induced CRC suppression by promoting autophagy through the LKB1/AMPK signaling. [Abstract]

2019 Aug 13;10(8):615. PMID: 31409796
Cell Death Dis

YAP-dependent ubiquitination and degradation of β-catenin mediates inhibition of Wnt signalling induced by Physalin F in colorectal cancer. [Abstract]

2018 May 22;9(6):591. PMID: 29789528
Proc Natl Acad Sci U S A

Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain. [Abstract]

2017 Mar 7;114(10):E1825-E1832. PMID: 28223528
Nano Res

2025 Oct.
Cell Commun Signal

Transcriptional deregulation by FOXM1-JUP signaling confers dual oncogenic drivers for pancreatic tumorigenesis and therapeutic resistance. [Abstract]

2025 Nov 27;23(1):513. PMID: 41310714
Cell Commun Signal

Activation of mechanosensitive ion channel Piezo1 linking metabolic reprogramming and pro-inflammatory responses in hepatocellular carcinoma. [Abstract]

2025 Jun 13;23(1):280. PMID: 40514668
Dev Cell

2026 Jun 10.
View

2023 Nov 15.
Acta Pharmacol Sin

Calcipotriol abrogates cancer-associated fibroblast-derived IL-8-mediated oxaliplatin resistance in gastric cancer cells via blocking PI3K/Akt signaling. [Abstract]

2023 Jan;44(1):178-188. PMID: 35676532
Acta Pharmacol Sin

Osimertinib successfully combats EGFR-negative glioblastoma cells by inhibiting the MAPK pathway. [Abstract]

2021 Jan;42(1):108-114. PMID: 32398685
Phytomedicine

Huangqi Guizhi Wuwu decoction alleviate Oxaliplatin-Induced Peripheral Neuropathy by adjusting the myelin regeneration. [Abstract]

2025 Sep:145:157039. PMID: 40618490
Phytomedicine

Erianin triggers ferroptosis in colorectal cancer cells by facilitating the ubiquitination and degradation of GPX4. [Abstract]

2025 Apr:139:156465. PMID: 39938177
Phytomedicine

Gegen Qinlian Decoction reverses oxaliplatin resistance in colorectal cancer by inhibiting YTHDF1-regulated m6A modification of GLS1. [Abstract]

2024 Jul 25:133:155906. PMID: 39089089
Phytomedicine

Compound-composed Chinese medicine of Huachansu triggers apoptosis of gastric cancer cells through increase of reactive oxygen species levels and suppression of proteasome activities. [Abstract]

2024 Jan:123:155169. PMID: 37992493
ACS Appl Mater Interfaces

Primary Human Gastric Cancer Cells Integrated Hydrogel Microcapsules for Personalized Drug Screening. [Abstract]

2026 Feb 11;18(5):7900-7909. PMID: 41615381
Apoptosis

Nicotine suppresses ferroptosis in colon cancer cells via HMOX1/NF-κB pathway to reduce oxaliplatin sensitivity. [Abstract]

2026 Mar 19;31(3):102. PMID: 41851365
Neoplasia

MYH knockdown in pancreatic cancer cells creates an exploitable DNA repair vulnerability. [Abstract]

2025 Feb 11:61:101138. PMID: 39938155
J Transl Med

Fusobacterium nucleatum enhances oxaliplatin resistance in colon cancer by increasing PVT1 expression. [Abstract]

2025 Oct 16;23(1):1112. PMID: 41102802
Biomed Pharmacother

Synergistic enhancement of anticancer effects by periodontal ligament stem cell exosomes and oxaliplatin via apoptosis induction and protein modulation. [Abstract]

2025 Aug 19:191:118481. PMID: 40834748
Biomed Pharmacother

Expediting the development of robust 5-FU-resistant colorectal cancer models using innovative combined in vivo and in vitro strategies. [Abstract]

2024 Nov:180:117576. PMID: 39442235
Biomed Pharmacother

Rupatadine inhibits colorectal cancer cell proliferation through the PIP5K1A/Akt/CDK2 pathway. [Abstract]

2024 Jun 4:176:116826. PMID: 38838507
Biomed Pharmacother

Nanocarrier mediated entinostat and oxaliplatin combination therapy displayed enhanced efficacy against pancreatic cancer. [Abstract]

2024 May 16:175:116743. PMID: 38759290
Biomed Pharmacother

Patient-derived organoid culture of gastric cancer for disease modeling and drug sensitivity testing. [Abstract]

2023 Jul:163:114751. PMID: 37105073
Biomed Pharmacother

Mitochondrial DNA content reduction induces aerobic glycolysis and reversible resistance to drug-induced apoptosis in SW480 colorectal cancer cells. [Abstract]

2018 Jul:103:729-737. PMID: 29684851
Oncogene

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2025 Sep 18. PMID: 40968255
Oncogene

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Cell Chem Biol

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Cell Rep

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Cell Rep

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Int J Nanomedicine

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2021 Jan 15;210:113080. PMID: 33310286
Int J Mol Med

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2026 Jan;57(1):4. PMID: 41133455
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2026 Feb 28;15(5):430. PMID: 41827864
Cells

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Food Hydrocoll Health

2025 Jun.
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Biol Direct

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2024 Sep 11;19(1):79. PMID: 39256753
Int J Mol Sci

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2023 Jun 8;24(12):9899. PMID: 37373047
Int J Oncol

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2022 Nov;61(5):139. PMID: 36169178
Int Immunopharmacol

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2024 May 10:134:112197. PMID: 38733826
Eur J Pharmacol

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2024 Jul 5:974:176538. PMID: 38552940
Int J Cancer

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2020 Mar 15;146(6):1700-1716. PMID: 31381140
Mol Oncol

Patient therapy outcome modeling in cancer organoids is improved by cancer-associated fibroblasts and organoid assembly convolution. [Abstract]

2026 Jun 5. PMID: 42246237
Mol Oncol

Optimized low-dose combinatorial drug treatment boosts selectivity and efficacy of colorectal carcinoma treatment. [Abstract]

2020 Nov;14(11):2894-2919. PMID: 33021054

Oxaliplatin purchased from MedChemExpress. Usage Cited in: Mol Oncol. 2020 Nov;14(11):2894-2919. [Abstract]

FOLFOX was administered as 6 mg/kg Oxaliplatin two hours before administration of 90 mg/kg Leucovorin and 50 mg/kg 5-Fluorouracil at day 1 and a repeat of 5‐Fluorouracil dosing on day 2. Weight loss of ODC-, CTRL-, and FOLFOX-treated mice over time of mice with DLD1 tumors.
Cancers (Basel)

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2023 Sep 6;15(18):4442. PMID: 37760412
Clin Epigenetics

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2022 Dec 24;14(1):184. PMID: 36566204
Cancers (Basel)

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2022 Apr 6;14(7):1848. PMID: 35406624
ACS Omega

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2025 Oct 30;10(44):52931-52943. PMID: 41244442
Pharm Res

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2025 Nov 18. PMID: 41254319
Cancer Sci

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2023 Jul;114(7):2951-2960. PMID: 37158138
FEBS J

The sulfonamide anticancer agent indisulam enhances the chemosensitivity of gastric cancer cells by targeting FKBP8. [Abstract]

2026 Mar 20. PMID: 41860182
FEBS J

Oxaliplatin accelerates immunogenic cell death by activating the cGAS/STING/TBK1/IRF5 pathway in gastric cancer. [Abstract]

2025 Apr 22. PMID: 40260556
Bioengineered

Memantine ameliorates oxaliplatin-induced neurotoxicity via mitochondrial protection. [Abstract]

2022 Mar;13(3):6688-6697. PMID: 35235756
J Mol Med (Berl)

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2019 Aug;97(8):1183-1193. PMID: 31201471
Transl Oncol

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2025 Oct:60:102491. PMID: 40773827
iScience

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2024 Dec 4;27(12):111437. PMID: 39717085
Neurochem Int

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2025 May:185:105961. PMID: 40054499
Front Cell Neurosci

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2017 Jul 21:11:219. PMID: 28785206
Sci Rep

Targeting colorectal cancer with pyrazolo[4,3-e][1,2,4]triazine and pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulfonamides: comprehensive in vitro evaluation. [Abstract]

2026 May 31. PMID: 42225755
Sci Rep

Chemotherapy-derived DAMPs drive reprogramming of tumor-associated macrophages toward a pro-inflammatory phenotype in hepatocellular carcinoma. [Abstract]

2026 Apr 3;16(1):17440. PMID: 41933190
Sci Rep

miR-340 reverses chemotherapy resistance in colon cancer via the PDCD4/WNT/β-catenin signalling pathway. [Abstract]

2025 Sep 29;15(1):33421. PMID: 41022995
Sci Rep

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2024 Nov 29;14(1):29661. PMID: 39613883
Sci Rep

Nrf2 inhibition increases sensitivity to chemotherapy of colorectal cancer by promoting ferroptosis and pyroptosis. [Abstract]

2023 Sep 1;13(1):14359. PMID: 37658132
Oncol Rep

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2020 Feb;43(2):405-414. PMID: 31894341
Sci Rep

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2016 Dec 1;6:38267. PMID: 27905569
Clin Immunol

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2023 Nov:256:109774. PMID: 37774907
Cancer Res Treat

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2023 Oct;55(4):1077-1086. PMID: 37309112
ACS Pharmacol Transl Sci

T‑Cell Immunoreceptor with Ig and Immunoreceptor Tyrosine-Based Inhibitory Motif Domains/Cluster of Differentiation 40 Cellular Nanovesicles Carrying Oxaliplatin Exhibited Superior Pancreatic Cancer Cells Therapy. [Abstract]

2026 Mar 28;9(4):1010-1020. PMID: 41988365
Biochim Biophys Acta Mol Cell Res

Reduced store operated calcium entry contributes to autophagy mediated escape of prostate cancer to oxaliplatin treatment. [Abstract]

2025 Apr 4:119953. PMID: 40189057
ACS Pharmacol Transl Sci

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2024 Nov 12;7(12):3935-3944. PMID: 39698293
Biochim Biophys Acta Mol Cell Res

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2024 Sep 14:119846. PMID: 39284549
Digestion

KIF4A Facilitates Oxaliplatin Resistance and Stemness in Colon Cancer by Boosting Glucose Metabolism. [Abstract]

2025 Mar 27:1-19. PMID: 40147432
Heliyon

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2023 Jun 1;9(6):e16872. PMID: 37313175
Heliyon

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2026 Mar 12. PMID: 41820205
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Dalton Trans

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Pathol Res Pract

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Mol Carcinog

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PLoS One

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Biochem Biophys Res Commun

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Biochem Biophys Res Commun

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Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 2 mg/mL (5.03 mM; ultrasonic and warming and heat to 60°C; DMSO can inactivate Oxaliplatin's activity)

DMF : 1.67 mg/mL (4.20 mM; Need ultrasonic; DMSO can inactivate Oxaliplatin's activity)

Ethanol : < 1 mg/mL (insoluble; DMSO can inactivate Oxaliplatin's activity)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5171 mL

12.5853 mL

25.1705 mL

5 mM

0.5034 mL

2.5171 mL

5.0341 mL

10 mM

---

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 5% w/v Glucose Solution

Solubility: 3.33 mg/mL (8.38 mM); Clear solution; Need ultrasonic

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (294 KB)
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Portuguese - PT (419 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Raymond E, et al. Oxaliplatin: a review of preclinical and clinical studies. Ann Oncol. 1998 Oct;9(10):1053-71. [Content Brief]

[2]. Mohammed MQ, et al. Oxaliplatin is active in vitro against human melanoma cell lines: comparison with NSC 119875 and NSC 241240. Anticancer Drugs. 2000 Nov;11(10):859-63. [Content Brief]

[3]. Pendyala L, et al. In vitro cytotoxicity, protein binding, red blood cell partitioning, and biotransformation of oxaliplatin. Cancer Res. 1993 Dec 15;53(24):5970-6. [Content Brief]

[4]. Wang Z, et al. Oxaliplatin induces apoptosis in hepatocellular carcinoma cells and inhibits tumor growth. Expert Opin Investig Drugs. 2009 Nov;18(11):1595-604 [Content Brief]

[5]. Mathé G, et al. Oxalato-platinum or 1-OHP, a third-generation platinum complex: an experimental and clinical appraisal and preliminary comparison with cis-platinum. Biomed Pharmacother. 1989;43(4):237-50. [Content Brief]

[6]. Schellingerhout D, et al. Impairment of retrograde neuronal transport in oxaliplatin-induced neuropathy demonstrated by molecular imaging. PLoS One. 2012;7(9):e45776. doi: 10.1371/journal.pone.0045776. Epub 2012 Sep 20. [Content Brief]

[7]. Park GY, et al. Phenanthriplatin, a monofunctional DNA-binding platinum anticancer drug candidate with unusual potency and cellular activity profile. Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):11987-92. [Content Brief]

[8]. Yi Yao, et al. Comparative proteomic analysis of colon cancer cells in response to oxaliplatin treatment. Biochim Biophys Acta. 2009 Oct;1794(10):1433-40. [Content Brief]

[9]. Garrett MJ, et, al. Capecitabine, Oxaliplatin, and Bevacizumab (BCapOx) Regimen for Metastatic Colorectal Cancer. Hosp Pharm. 2017 May;52(5):341-347. [Content Brief]

[10]. Jiang Y, et al. Oxaliplatin-induced neuropathic pain in cancer: animal models and related research progress. Front Pharmacol. 2025 May 30;16:1609791. [Content Brief]

[11]. Xiao WH, et al. Characterization of oxaliplatin-induced chronic painful peripheral neuropathy in the rat and comparison with the neuropathy induced by paclitaxel. Neuroscience. 2012 Feb 17;203:194-206. [Content Brief]

[12]. Dehghani S, et al. Neuroinflammatory Mechanisms and Therapeutic Targets in Oxaliplatin-Induced Peripheral Neuropathy: a Comprehensive Review. Neurotox Res. 2025 Dec 13;43(6):52. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMF / H₂O	1 mM	2.5171 mL	12.5853 mL	25.1705 mL	62.9263 mL
H₂O	5 mM	0.5034 mL	2.5171 mL	5.0341 mL	12.5853 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Oxaliplatin

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