Acivicin
Based on 2 publication(s) in Google Scholar
Acivicin (AT-125), a natural product produced by Streptomyces sviceus is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin can across the blood-brain barrier and has anti-cancer, anti-parasitic properties.
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- Reinheit: 99.94%
- CAS. Nr.: 42228-92-2
- Formel: C5H7ClN2O3
- Molecular Weight:178.57
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Speicherung:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Acivicin
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Biologische Aktivität
γ-glutamyl transpeptidase[1]
Acivicin (AT-125; 0.1-50 μM; 5 days) has an IC50 of 0.7 μM in human HepG2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male pigmented Long-Evans rats weighed between 250 g and 300 g exposed to Toluene[3]
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Dosage:5 mg/kg
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Administration:IP; twice weekly (monday and wednesday)
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Result:Reduced urinary γ-GT by 70-78%.
Chemical Information
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CAS. Nr. 42228-92-2
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Appearance Solid
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Molecular Weight 178.57
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Formel C5H7ClN2O3
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Color White to light yellow
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SMILES
ClC1=NO[C@@]([C@H](N)C(O)=O)([H])C1
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Synonyms
AT-125; U-42126
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Structure Classification
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Initial Source
Streptomyces sviceus
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (2)
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Journal Impact Factor
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Most Recent
Lösungsmittel & Löslichkeit
H2O : 6.67 mg/mL (37.35 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (276 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Kreuzer J, et al. Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition. Chem Sci. 2014 Dec 1;6(1):237-245. Epub 2014 Sep 26. [Content Brief]
[2]. Chikhale EG, et al. Carrier-mediated transport of the antitumor agent acivicin across the blood-brain barrier. Biochem Pharmacol. 1995 Mar 30;49(7):941-5. [Content Brief]
[3]. Delphine Waniusiow, et al. Toluene-induced hearing loss in acivicin-treated rats. Neurotoxicol Teratol. May-Jun 2008;30(3):154-60. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.6000 mL | 28.0002 mL | 56.0004 mL | 140.0011 mL |
| 5 mM | 1.1200 mL | 5.6000 mL | 11.2001 mL | 28.0002 mL | |
| 10 mM | 0.5600 mL | 2.8000 mL | 5.6000 mL | 14.0001 mL | |
| 15 mM | 0.3733 mL | 1.8667 mL | 3.7334 mL | 9.3334 mL | |
| 20 mM | 0.2800 mL | 1.4000 mL | 2.8000 mL | 7.0001 mL | |
| 25 mM | 0.2240 mL | 1.1200 mL | 2.2400 mL | 5.6000 mL | |
| 30 mM | 0.1867 mL | 0.9333 mL | 1.8667 mL | 4.6667 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Acivicin Related Classifications
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