AS2795440
AS2795440 is a PIKfyve inhibitor. AS2795440 selectively inhibits proinflammatory cytokine such as IL-12p40 and IL-6 production and B cell activation without affecting Ca2+ signaling. AS2795440 significantly reduces joint inflammation and bone loss in adjuvant-induced arthritis (AIA) mice model. AS2795440 can be used for inflammatory and autoimmune diseases like rheumatoid arthritis, psoriasis and inflammatory bowel disease research.
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- CAS. Nr.: 2171506-45-7
- Formel: C29H32N6O
- Molecular Weight:480.60
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
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IL-6 |
IL-12p40 |
MHC II |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
2 nM
Compound: 71; AS2795440
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Antiinflammatory activity in mouse RAW264.7 cells assessed as effect on LPS induced IL-12p40 level measured after 24 hrs by RT-qPCR analysis
Antiinflammatory activity in mouse RAW264.7 cells assessed as effect on LPS induced IL-12p40 level measured after 24 hrs by RT-qPCR analysis
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[PMID: 37981443] |
Chemical Information
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CAS. Nr. 2171506-45-7
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Molecular Weight 480.60
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Formel C29H32N6O
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SMILES
CC(NC1=C2N=C(C(NC3=C(N=CC(C4=CC=C(N=C4)C(CC5)=CCN5C(C)C)=C3)C)=O)C=C1)=C2C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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