BAY-7598
BAY-7598, a chemical probe, is a potent, orally bioavailable, and selective MMP12 inhibitor with IC50s of 0.085, 0.67 and 1.1 nM for human MMP12, murine MMP12, and rat MMP12, respectively.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 1816257-74-5
- Formel: C28H31N3O6
- Molecular Weight:505.56
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
IC50: 0.085 nM (human MMP12), 0.67 nM (murine MMP12), 1.1 nM (rat MMP12)[1]
BAY-7598 inhibits human MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP13, MMP14, and MMP16 with IC50s of 44, 360, 600, 15, 460, 12, 67, 250, and 940 nM, respectively[1].
BAY-7598 inhibits murine MMP2, MMP3, MMP7, MMP8, and MMP9 with IC50s of 45, 270, 130, 54, and 210 nM, respectively[1].
BAY-7598 inhibits rat MMP2, MMP8, and MMP9 with IC50s of 45, 67, and 1000 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mouse[1]
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Dosage:0.3 mg/kg (i.v.) and 5.0 mg/kg (p.o.)
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Administration:Administered i.v. (0.3 mg/kg) and p.o. (5.0 mg/kg) (Pharmacokinetic Analysis)
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Result:T1/2=4.6 h and 4.1 h for 0.3 mg/kg (i.v.) and 5.0 mg/kg (p.o.), respectively.
Chemical Information
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CAS. Nr. 1816257-74-5
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Molecular Weight 505.56
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Formel C28H31N3O6
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SMILES
O=C([C@H]1[C@H](CN2N=NC3=CC=CC=C3C2=O)CC[C@@H]1C(C4=CC=C(OCCC5CCOCC5)C=C4)=O)O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
BAY-7598 Related Classifications
HY-120944 Related Classifications
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