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Art. -Nr.: HY-U00134A

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Benzcyclane fumarate

(Synonyms: Bencyclane fumarate; Benzcyclan fumarate)

Benzcyclane fumarate (Bencyclane fumarate; Benzcyclan fumarate) is a vasodilator with serotonin receptor antagonism. Benzcyclane fumarate exerts atypical serotonin antagonistic effects in rabbit superior mesenteric arteries. Benzcyclane fumarate relaxes high K⁺-induced contractions in rabbit basilar arteries and superior mesenteric arteries, and selectively inhibits sympathetic nerve stimulation-induced contractions in rabbit pulmonary arteries. Benzcyclane fumarate exerts non-competitive norepinephrine antagonistic effects in rabbit superior mesenteric arteries, and slightly reduces the maximum contractile response induced by histamine. Benzcyclane fumarate relaxes smooth muscles, induces transient hypotension, inhibits thrombosis, and accelerates blood fibrinolytic activity. Benzcyclane fumarate increases cerebral glucose content/uptake, enhances hypoxia tolerance in mice, and increases cerebral blood supply in dogs. Benzcyclane fumarate is applicable to studies related to cerebral vascular circulation.

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CAS. Nr.: 14286-84-1
Formel: C₂₃H₃₅NO₅
Molecular Weight:405.53

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Benzcyclane fumarate Chemical Structure

CAS. Nr.: 14286-84-1

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In Vitro

Benzcyclane (0.0001-0.03 mg/mL; 2-3 minutes per concentration, 10-20 minutes for maximum relaxation) fumarate potently relaxes high K⁺-induced contractures in isolated rabbit basilar artery strips with an ED₅₀ of 0.0011 mg/mL, producing faster and more marked relaxation than in mesenteric artery strips^[1].
Benzcyclane fumarate (~30 minutes for maximum relaxation) relaxes high K⁺-induced contractures in isolated rabbit superior mesenteric artery strips with an ED₅₀ of 0.0048 mg/mL, showing weaker and slower relaxation than in basilar artery strips^[1].
Benzcyclane fumarate exerts the strongest antagonistic effect on serotonin-induced contractions in isolated rabbit superior mesenteric artery strips (presumptive pA₂ = 7.3), with weaker noncompetitive antagonism of noradrenaline (pD₂' = 4.3) and minimal effect on histamine (pD₂' = 3.8)^[1].
Benzcyclane (0.006 mg/mL, 0.01 mg/mL; 30 minutes for nerve stimulation, 20 minutes for noradrenaline) fumarate selectively inhibits 25 Hz sympathetic nerve-induced contractions in isolated rabbit pulmonary artery radial muscle preparations without affecting responses to exogenous noradrenaline^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 14286-84-1
Molecular Weight 405.53
Formel C₂₃H₃₅NO₅
SMILES

CN(C)CCCOC1(CC2=CC=CC=C2)CCCCCC1.O=C(O)/C=C/C(O)=O
Synonyms

Bencyclane fumarate; Benzcyclan fumarate
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Egawa M, et al. Comparative studies of cerebral vasodilators on relaxation activities in isolated basilar, mesenteric and pulmonary arteries of rabbits. Jpn J Pharmacol. 1982 Apr;32(2):273-81. [Content Brief]

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Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Benzcyclane fumarate

Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen

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Benzcyclane fumarate Related Classifications

HY-U00134A Related Classifications