Buddledin A
Buddledin A is a 5-LOX inhibitor (IC50 = 50.4 μM) and a COX inhibitor (IC50 = 13.7 μM). Buddedin A inhibits arachidonic acid metabolism via the 5-LOX and COX pathways, suppresses fungal growth, and exerts toxic effects on fish. Buddedin A may play an ecological role in protecting plant roots and stem barks from fungal infection. Buddedin A can be used in studies related to fungal infections.
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- CAS. Nr.: 62346-20-7
- Formel: C17H24O3
- Molecular Weight:276.37
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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5-LOX |
Buddledin A potently inhibits COX activity in activated rat peritoneal leukocytes, with an IC50 value of 13.7 μM[1].
Buddledin A inhibits the activity of 5-LOX in activated rat peritoneal leukocytes, with an IC50 of 50.4 μM[1].
Buddledin A (12.5 mg/mL) inhibits the growth of Epidermophyton floccosum, Trichophyton interdigitale, Fusarium graminearum and Sordaria fimicola, with an MIC of 12.5 mg/mL[2].
Buddledin A (10 mg/m, 25°C, after 5 to 7 days) inhibits the growth of Fusarium solani[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 62346-20-7
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Molecular Weight 276.37
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Formel C17H24O3
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SMILES
O=C(/C(C)=C/CC1)[C@H](OC(C)=O)[C@@]2([H])C(C)(C)C[C@]2([H])C1=C
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Liao YH, et al. Novel and known constituents from Buddleja species and their activity against leukocyte eicosanoid generation. J Nat Prod. 1999;62(9):1241-1245. [Content Brief]
[2]. Houghton PJ, et al. Terpenoids in Buddleja: relevance to chemosystematics, chemical ecology and biological activity. Phytochemistry. 2003;64(2):385-393. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Buddledin A Related Classifications
HY-N19724 Related Classifications
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