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Art. -Nr.: HY-118558

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Buthiobate

Name: Buthiobate
Brand: MedChemExpress
SKU: HY-118558
Availability: PreOrder

(Synonyms: S-1358)

Buthiobate (S-1358) is a fungicide. Buthiobate is a cytochrome P-450 inhibitor with an IC₅₀ of 0.4 μM. Buthiobate binds to the heme iron of cytochrome P-450 (low-spin state) via its pyridine group, thereby blocking the initial hydroxylation of the 14α-methyl group. Buthiobate is used in research on powdery mildew in agricultural and horticultural crops.

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CAS. Nr.: 51308-54-4
Formel: C₂₁H₂₈N₂S₂
Molecular Weight:372.59

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Buthiobate Chemical Structure

CAS. Nr.: 51308-54-4

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Beschreibung

Alle Cytochrome P450 Isoform-spezifische Produkte anzeigen :

In Vitro

Buthiobate (0.4-10 μM; 30 min) potently inhibits lanosterol 14α-demethylase activity in rat liver microsomes with an IC₅₀ of 0.4 μM, and achieves near-complete inhibition at 10 μM^[1].
Buthiobate (10^-6-10^-4 M; 3 h) potently inhibits C-14 demethylation in ergosterol biosynthesis in cell-free homogenates of Saccharomyces cerevisiae, with the strongest effect observed at 10^-4 M, resulting in accumulation of lanosterol and reduced formation of downstream sterols^[2].
Buthiobate (various concentrations; 36 μM) binds to three distinct low-spin cytochrome P-450 species in rat liver microsomes with K_D values ranging from 0.38 to 13.2 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

CAS. Nr. 51308-54-4
Molecular Weight 372.59
Formel C₂₁H₂₈N₂S₂
SMILES

CCCCS/C(SCC1=CC=C(C=C1)C(C)(C)C)=N\C2=CC=CN=C2
Synonyms

S-1358
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Yoshida Y, et al. Effects of buthiobate, a fungicide, on cytochrome P-450 of rat liver microsomes. Journal of pharmacobio-dynamics. 1985 Jun;8(6):432-9.

[2]. Kato T, et al. Selective inhibition of the demethylation at C-14 in ergosterol biosynthesis by the fungicide, Denmert (S-1358). Agricultural and Biological Chemistry, 1976, 40(12): 2379-2388.

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Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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Buthiobate

Alle Cytochrome P450 Isoform-spezifische Produkte anzeigen

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