CPPG
Based on 1 Customer Validation
CPPG ((RS)-CPPG) is a potent group II/III mGlu receptors antagonist. CPPG exhibits some selectivity (approximately 20 fold) for group III (IC50=2.2 nM) over group II (IC50=46.2 nM) mGlu receptors in the rat cerebral cortex. CPPG has weak effects at group I mGlu receptors.
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- Reinheit: 99.38%
- CAS. Nr.: 183364-82-1
- Formel: C11H14NO5P
- Molecular Weight:271.21
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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group III mGlu receptors 2.2 nM (IC50) |
group II mGlu receptors 46.2 nM (IC50) |
CPPG ((RS)-CPPG) potently reversed both L-AP4 (IC50=2.2 nM)- and L-CCG-I (IC50=46.2 nM) -mediated inhibition of forskolin-stimulated cyclic AMP accumulation in adult rat cortical slices. CPPG is a potent antagonist against group II/III mGlu receptors in the adult rat cortex and shows moderate selectivity for group III mGlu receptors. Conversely, CPPG has weak effects at group I mGlu receptors in both the neonatal rat cortex and cultured cerebellar granule cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 183364-82-1
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Appearance Solid
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Molecular Weight 271.21
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Formel C11H14NO5P
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Color White to off-white
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SMILES
O=C(O)C(C1CC1)(N)C2=CC=C(P(O)(O)=O)C=C2
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Synonyms
(RS)-CPPG
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
1M NaOH : 50 mg/mL (184.36 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| 1M NaOH | 1 mM | 3.6872 mL | 18.4359 mL | 36.8718 mL | 92.1795 mL |
| 5 mM | 0.7374 mL | 3.6872 mL | 7.3744 mL | 18.4359 mL | |
| 10 mM | 0.3687 mL | 1.8436 mL | 3.6872 mL | 9.2179 mL | |
| 15 mM | 0.2458 mL | 1.2291 mL | 2.4581 mL | 6.1453 mL | |
| 20 mM | 0.1844 mL | 0.9218 mL | 1.8436 mL | 4.6090 mL | |
| 25 mM | 0.1475 mL | 0.7374 mL | 1.4749 mL | 3.6872 mL | |
| 30 mM | 0.1229 mL | 0.6145 mL | 1.2291 mL | 3.0726 mL | |
| 40 mM | 0.0922 mL | 0.4609 mL | 0.9218 mL | 2.3045 mL | |
| 50 mM | 0.0737 mL | 0.3687 mL | 0.7374 mL | 1.8436 mL | |
| 60 mM | 0.0615 mL | 0.3073 mL | 0.6145 mL | 1.5363 mL | |
| 80 mM | 0.0461 mL | 0.2304 mL | 0.4609 mL | 1.1522 mL | |
| 100 mM | 0.0369 mL | 0.1844 mL | 0.3687 mL | 0.9218 mL |
CPPG Related Classifications
HY-101333 Related Classifications
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