DCG-IV
Based on 1 Customer Validation
DCG-IV is a potent agonist of group II mGluRs with EC50s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC50: mGlu1R/5R=389/630 μM) and III receptors (IC50: mGlu4R/6R/7R/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.9%
- CAS. Nr.: 147782-19-2
- Formel: C7H9NO6
- Molecular Weight:203.15
-
Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
-
Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
|
mGluR2R 0.35 μM (EC50) |
mGluR3R 0.09 μM (EC50) |
mGluR1R 389 μM (IC50) |
mGluR5 630 μM (IC50) |
mGluR4R 22.5 μM (IC50) |
mGluR6 39.6 μM (IC50) |
mGluR7 40.1 μM (IC50) |
mGluR8 32 μM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
45 nM
Compound: DCG-IV
|
Agonist activity at rat mGlu2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 1 hr by fluorescence microplate reader
Agonist activity at rat mGlu2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 1 hr by fluorescence microplate reader
|
[PMID: 20218620] |
| HEK293 | IC50 |
389 μM
Compound: 19
|
Inhibitory activity against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells.
Inhibitory activity against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells.
|
[PMID: 10229625] |
DCG-IV is also an NMDA receptor agonist in the rat cortical slice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male ICR mice weighing about 40 g (PCP-induced locomotor activity)[4]
-
Dosage:10, 5, or 1 mg/kg
-
Administration:I.p.
-
Result:Reduced spontaneous activities of the animals at 10 or 5 mg/kg.
Chemical Information
-
CAS. Nr. 147782-19-2
-
Appearance Solid
-
Molecular Weight 203.15
-
Formel C7H9NO6
-
Color White to off-white
-
SMILES
O=C([C@H]1[C@H](C(O)=O)C1[C@H](N)C(O)=O)O
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
H2O : ≥ 20 mg/mL (98.45 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
-
Data Sheet (275 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
Verweise
[1]. Brabet I, et al. Comparative effect of L-CCG-I, DCG-IV and gamma-carboxy-L-glutamate on all clonedmetabotropic glutamate receptor subtypes. Neuropharmacology. 1998 Aug;37(8):1043-51. [Content Brief]
[2]. Bertrand HO, et al. Common and selective molecular determinants involved in metabotopic glutamate receptoragonist activity. J Med Chem. 2002 Jul 18;45(15):3171-83. [Content Brief]
[3]. Uyama Y, et al. DCG-IV, a potent metabotropic glutamate receptor agonist, as an NMDA receptor agonist in the rat cortical slice. Brain Res. 1997 Mar 28;752(1-2):327-30. [Content Brief]
[4]. Tomita N, et al. The effects of DCG-IV and L-CCG-1 upon phencyclidine (PCP)-induced locomotion and behavioral changes in mice. Ann N Y Acad Sci. 2000 Sep;914:284-91. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.9225 mL | 24.6124 mL | 49.2247 mL | 123.0618 mL |
| 5 mM | 0.9845 mL | 4.9225 mL | 9.8449 mL | 24.6124 mL | |
| 10 mM | 0.4922 mL | 2.4612 mL | 4.9225 mL | 12.3062 mL | |
| 15 mM | 0.3282 mL | 1.6408 mL | 3.2816 mL | 8.2041 mL | |
| 20 mM | 0.2461 mL | 1.2306 mL | 2.4612 mL | 6.1531 mL | |
| 25 mM | 0.1969 mL | 0.9845 mL | 1.9690 mL | 4.9225 mL | |
| 30 mM | 0.1641 mL | 0.8204 mL | 1.6408 mL | 4.1021 mL | |
| 40 mM | 0.1231 mL | 0.6153 mL | 1.2306 mL | 3.0765 mL | |
| 50 mM | 0.0984 mL | 0.4922 mL | 0.9845 mL | 2.4612 mL | |
| 60 mM | 0.0820 mL | 0.4102 mL | 0.8204 mL | 2.0510 mL | |
| 80 mM | 0.0615 mL | 0.3077 mL | 0.6153 mL | 1.5383 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
DCG-IV Related Classifications
HY-101335 Related Classifications
Powered by Bioz