Dovramilast
Based on 1 Customer Validation
Dovramilast (CC-11050) is an orally active phosphodiesterase 4 (PDE4) inhibitor and can reduce the inflammatory response and improves Isoniazid (HY-B0329)-mediated bacillary clearance from the lungs. Dovramilast, as an adjunct, is used for the research of tuberculosis (TB).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.66%
- CAS. Nr.: 340019-69-4
- Formel: C24H28N2O6S
- Molecular Weight:472.55
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Speicherung:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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PDE4 |
Pharmacokinetic Parameters of Dovramilast in B6D2F1 mice[2].
| Sampling time(h) | Concentration(ng/ml) | ||||
| CC-11050 only | CC-11050+INH | ||||
| 1 | 1,331.6±136.97 | 905.35±594.23 | |||
| 2 | 1,409.47±140.85 | 1,309.39±214.08 | |||
| 5 | 948.85±128.7 | 1,609.18±167.2 | |||
| 8 | 820.6±265.98 | 1,271.73±249.18 | |||
| 24 | 1.27±1.1 | 4.96±1.85 | |||
| Tmax(h) | 2.0 | 5.0 | |||
| Cmax(ng/ml) | 1,410 | 1,610 | |||
| AUClast(ng × h/ml) | 10,200 | 13,900 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:B6D2F1 mice[2]
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Dosage:5, 25, or 50 mg/kg
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Administration:oral, 5, 25, or 50 mg/kg, single
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Result:Reduced PDE4 expression in mtb-infected mouse lungs.
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Animal Model:B6D2F1 mice[2]
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Dosage:5, 25, or 50 mg/kg
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Administration:oral gavage, 5, 25, or 50 mg/kg, single
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Result:Improved antibiotic-mediated bacterial killing and reduced lung pathology.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 340019-69-4
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Appearance Solid
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Molecular Weight 472.55
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Formel C24H28N2O6S
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Color White to off-white
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SMILES
O=C(C1CC1)NC2=CC=CC(CN3[C@@H](C4=CC=C(OC)C(OCC)=C4)CS(=O)(C)=O)=C2C3=O
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Synonyms
CC-11050
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Lösungsmittel & Löslichkeit
DMSO : 25 mg/mL (52.90 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1162 mL | 10.5809 mL | 21.1618 mL | 52.9045 mL |
| 5 mM | 0.4232 mL | 2.1162 mL | 4.2324 mL | 10.5809 mL | |
| 10 mM | 0.2116 mL | 1.0581 mL | 2.1162 mL | 5.2904 mL | |
| 15 mM | 0.1411 mL | 0.7054 mL | 1.4108 mL | 3.5270 mL | |
| 20 mM | 0.1058 mL | 0.5290 mL | 1.0581 mL | 2.6452 mL | |
| 25 mM | 0.0846 mL | 0.4232 mL | 0.8465 mL | 2.1162 mL | |
| 30 mM | 0.0705 mL | 0.3527 mL | 0.7054 mL | 1.7635 mL | |
| 40 mM | 0.0529 mL | 0.2645 mL | 0.5290 mL | 1.3226 mL | |
| 50 mM | 0.0423 mL | 0.2116 mL | 0.4232 mL | 1.0581 mL |
Dovramilast Related Classifications
HY-147263 Related Classifications
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