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Art. -Nr.: HY-189947

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HDAC4-IN-3

HDAC4-IN-3 is a class IIa HDAC4 inhibitor. HDAC4-IN-3 disrupts the HDAC4-JunB transcriptional complex, thereby blocking HDAC4 cooperation with JunB to activate Th17 signature genes, and disrupts HDAC4-JunB interactions in Th17 cells with no detectable effect on HDAC7-Aiolos binding.

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Formel: C₂₇H₂₅F₃N₄O₃S
Molecular Weight:542.57

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (293 KB)

HDAC4-IN-3 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
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Verweise
Calculators
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Classifications
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Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

HDAC4

Alle HDAC Isoform-spezifische Produkte anzeigen :

In Vitro

Adaptive ImmunityCytokines & ChemokinesOthers

Adaptive Immunity

Cytokines & Chemokines

HDAC4-IN-3 (compound 15e) inhibits HDAC4-dependent Il17a/JunB transcription in Jurkat T cells with 1.87-fold the activity relative to TMP269 (HY-18360), and no HDAC7-dependent Il2/Aiolos activity is detected^[1].

Others

HDAC4-IN-3 (5 μM; 24 h) effectively disrupts the HDAC4-JunB interaction in Th17 cells, with activity comparable to TMP269^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Th17 cells
Concentration:

5 μM
Incubation Time:

24 h
Result:

Effectively disrupted the HDAC4-JunB interactions in Th17 cells, with activity
comparable to TMP269.

Related Protocols :

Naïve CD4+ T-cell subset differentiation/polarization

Chemical Information

Molecular Weight 542.57
Formel C₂₇H₂₅F₃N₄O₃S
SMILES

COC1=CC(C2=CSC(C3(CCOCC3)CNC(C4=CC(C5=CN(C(F)(F)F)N=C5)=CC=C4)=O)=N2)=CC=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (293 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Bharath Kumar Gajjela, et al. Structure-Guided Development of Selective HDAC4 and HDAC7 Inhibitors That Modulate Th17 Cell Transcription. ACS Med. Chem. Lett. 8 October 2026; 17 (10): 2206-2210.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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- In Vitro
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HDAC4-IN-3

Alle HDAC Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

In Vitro

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

HDAC4-IN-3 Related Classifications

HY-189947 Related Classifications

Bioz

Keywords

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