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Art. -Nr.: HY-153952

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Immuno modulator-1

Immuno modulator-1 (compound 22) inhibits TNFα and IL-2 secretion in human peripheral blood mononuclear cells (hPBMC), with IC₅₀ values of 4.7 and 26 nM, respectively. Immuno modulator-1 shows hERG potassium channel blocking effect, with Inhibitory percentage of 20% at 3 μM.

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CAS. Nr.: 2757469-20-6
Formel: C₃₂H₃₁FN₆O₄
Molecular Weight:582.62

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Immuno modulator-1 Chemical Structure

CAS. Nr.: 2757469-20-6

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Preis

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Menge

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IL-2

Alle TNF Receptor Isoform-spezifische Produkte anzeigen :

Alle Interleukin Related Isoform-spezifische Produkte anzeigen :

In Vitro

Immuno modulator-1 (compound 22) inhibits the proliferation of NCI-H929 human myeloma cell, with an IC₅₀ of 0.6 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Immuno modulator-1 (compound 22) (1 mg/kg (IV), 5 mg/kg (PO); once) has an oral bioavailability of 30% in Male Sprague-Dawley rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Sprague-Dawley rats^[1]
Dosage:

1 mg/kg (IV), 5 mg/kg (PO)
Administration:

IV (2 mL/kg), PO (10 mL/kg); once (Pharmacokinetic Analysis)
Result:

Pharmacokinetic Parameters of Immuno modulator-1 in male Sprague-Dawley rats^[1].

IV (1 mg/kg) PO (5 mg/kg)

C_max (ng/mL) 1437

AUC_0-24 (ng/mL∗h) 13029

CL (mL/min/kg) 2.2

Vss (L/kg) 0.36

F (%) 30%

Chemical Information

CAS. Nr. 2757469-20-6
Molecular Weight 582.62
Formel C₃₂H₃₁FN₆O₄
SMILES

C[C@@H](N1CCN(C2=C(C=C(C=N2)C#N)F)CC1)C(C=C3)=CC=C3COC4=C5C(C(N([C@@H]6C(NC(CC6)=O)=O)C5)=O)=CC=C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Chen Xiangyang, et al. Heterocyclic immunomodulator. Patent, WO2022007659A1.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

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CAS. Nr.:
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	IV (1 mg/kg)	PO (5 mg/kg)
C_max (ng/mL)		1437
AUC_0-24 (ng/mL∗h)		13029
CL (mL/min/kg)	2.2
Vss (L/kg)	0.36
F (%)		30%

Immuno modulator-1

Alle TNF Receptor Isoform-spezifische Produkte anzeigen

Alle Interleukin Related Isoform-spezifische Produkte anzeigen