Lysostaphin
Based on 1 publication(s) in Google Scholar
Lysostaphin is an antistaphylococcal agent. Lysostaphin has activities of three enzymes namely, glycylglycine endopeptidase, endo-β-N-acetyl glucosamidase and N-acteyl muramyl-L-alanine amidase.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 9011-93-2
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
-
Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
-
HY-K0010
Protease Inhibitor Cocktail (EDTA-Free, 100× in DMSO) -
HY-18739
Phorbol 12-myristate 13-acetatePKC Activator -
HY-114118
SemaglutideGLP-1R Agonist -
HY-D0940
H2DCFDAROS-Sensitive Probe -
HY-N0322
Cholesterol (from animal)ERRα Agonist -
HY-15763
ErastinFerroptosis Inducer -
HY-12591B
D-Luciferin potassiumSubstrate for Luciferase -
HY-B1756
RotenoneMitochondrial Complex I Inhibitor -
HY-W040193
DSPCLiposome Compound -
HY-19312
3-MethyladenineAutophagy/PI3K Inhibitor -
HY-10071
Y-27632ROCK Inhibitor -
HY-N0005
Curcuminp300 Histone Acetylatransferase Inhibitor
Publications Citing Use of MedChemExpress (MCE) Lysostaphin
MoreAlle Antibiotic Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
Beschreibung
In Vitro
Lysostaphin (16 μg/mL, 0-260 minutes) exerts its antibacterial effect by hydrolyzing the peptidoglycan cross-linkages of Staphylococcus aureus, weakening the mechanical strength of the cell wall and causing structural damage[3].
Product Information
Molecular weight: 27 kDa
Effective pH range: 5.0-8.0
Instructions
Can be dissolved in ddH2O at a concentration of 1 mg/mL. Fresh preparation is recommended. Or dissolve in buffer according to specific experimental references.
Notes
PCMB, PMSF, DTT, etc. have no obvious effect on enzyme activity at 1 mM. Ba2+, Mn2+, Ca2+, Mg2+ and EDTA show a certain degree of inhibitory effect on enzyme activity at a concentration of 1 mM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Systemic infection model in CF-1 mice induced by methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA)[2]
-
Dosage:1, 5, 25, 50 mg/kg
-
Administration:Intravenous injection (i.v.), single high-dose administration: 25 mg/kg or 50 mg/kg intravenous injection, single dose; Once daily administration: 1 or 5 mg/kg, once daily for 3 days.
-
Result:Cleared MSSA from the blood and organs of mice (5 mg/kg for 3 days). Cleared MSSA and MRSA from the kidneys, spleen, and liver (A higher single dose of 50 mg/kg). Improved effectiveness and allowed reduction of the lysostaphin dose to 1 mg/kg for MRSA infections (Combined with Oxacillin (HY-B0925A) or Vancomycin (HY-B0671)).
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
EC Number
3.4.24.75
Enzyme Activity
≥1200 U/mg soild
Unit Definition
One unit is defined as the amount of enzyme required to reduce the OD620 absorption value by 0.01 per minute at 37°C and pH 7.5
Chemical Information
-
CAS. Nr. 9011-93-2
-
Appearance Solid
-
Color White to off-white
-
SMILES
[Lysostaphin]
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
bioRxiv
Lipolysis of host triacylglyceride-rich lipoproteins creates a toxic microenvironment for Staphylococcus aureus. [Abstract]2026 Jan 12:2026.01.12.699058. PMID: 41648463
Lösungsmittel & Löslichkeit
In Vitro:
H2O : ≥ 1 mg/mL
* "≥" means soluble, but saturation unknown.
Reinheit & Dokumentation
-
Data Sheet (272 KB)
-
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
-
Handling Instructions (2659 KB)
Verweise
[1]. Jaspal K Kumar, et al. Lysostaphin: An Antistaphylococcal Agent. Appl Microbiol Biotechnol. 2008 Sep;80(4):555-61. [Content Brief]
[2]. Kokai-Kun JF, et al. Lysostaphin as a treatment for systemic Staphylococcus aureus infection in a mouse model. J Antimicrob Chemother. 2007 Nov;60(5):1051-9. [Content Brief]
[3]. Francius G, et al. Direct observation of Staphylococcus aureus cell wall digestion by lysostaphin. J Bacteriol. 2008 Dec;190(24):7904-9. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Lysostaphin Related Classifications
HY-P2329 Related Classifications
Powered by Bioz